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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:34025
Term: 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Definition: A bisphenol that has formula C14H11Cl3O2.
Chemical ID: MESH:C404910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1decreases activityEXP 6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B1 proteinPMID:23333641
Hsd11b1multiple interactionsEXP 6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HSD11B1 mRNA]PMID:19414516
Hsd11b1decreases activityISOHSD11B1 (Homo sapiens)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of HSD11B1 proteinPMID:23333641
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