GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hsd11b1 | increases chemical synthesis | EXP | | 6480464 | CTD | HSD11B1 protein results in increased chemical synthesis of Corticosterone | PMID:23814014 | Hsd11b1 | increases expression | EXP | | 6480464 | CTD | Corticosterone results in increased expression of HSD11B1 mRNA | PMID:15755911 | Hsd11b1 | increases oxidation | EXP | | 6480464 | CTD | HSD11B1 protein results in increased oxidation of Corticosterone | PMID:26859423 | Hsd11b1 | multiple interactions | EXP | | 6480464 | CTD | [HSD11B1 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone; [HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone; resveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]; Ziram inhibits the reaction [[HSD11B1 protein results in increased reduction of 11-dehydrocorticosterone] which results in increased chemical synthesis of Corticosterone] | PMID:23814014 PMID:26859423 | Hsd11b1 | decreases abundance | ISO | Hsd11b1 (Mus musculus) | 6480464 | CTD | HSD11B1 gene mutant form results in decreased abundance of Corticosterone | PMID:25061560 | Hsd11b1 | increases chemical synthesis | ISO | Hsd11b1 (Mus musculus) | 6480464 | CTD | HSD11B1 protein results in increased chemical synthesis of Corticosterone | PMID:16751407 | Hsd11b1 | multiple interactions | ISO | Hsd11b1 (Mus musculus) | 6480464 | CTD | [[trimethyltin chloride results in increased abundance of trimethyltin] which co-treated with Corticosterone] results in increased expression of HSD11B1 mRNA; Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]; Mifepristone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] | PMID:30993381 | | ||||||||||||||||||||||
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