Fga (fibrinogen alpha chain) - Rat Genome Database

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Gene: Fga (fibrinogen alpha chain) Rattus norvegicus
Analyze
Symbol: Fga
Name: fibrinogen alpha chain
RGD ID: 2603
Description: Predicted to enable protein-macromolecule adaptor activity and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to phorbol 13-acetate 12-myristate; and liver regeneration. Located in blood microparticle. Used to study asthma; brain ischemia; disseminated intravascular coagulation; and thrombocytopenia. Biomarker of acute kidney failure; artery disease (multiple); disseminated intravascular coagulation; pancreatitis; and pulmonary emphysema. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac1873; Fba5e; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide see also D2Mit19 and D2Wox16; fibrinogen, A alpha polypeptide; Fibrinogen, A alpha polypeptide see also D2Mit19 and D2Wox16; fibrinogen, alpha polypeptide; MGC156536
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,672,169 - 170,679,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2170,672,012 - 170,679,577 (+)EnsemblGRCr8
mRatBN7.22168,374,120 - 168,381,523 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,374,120 - 168,381,528 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2175,564,269 - 175,571,651 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,585,204 - 173,592,586 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,186,618 - 168,194,000 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,997,562 - 182,013,726 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,006,242 - 182,013,763 (+)Ensemblrn6Rnor6.0
Rnor_5.02201,412,182 - 201,428,346 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42174,737,640 - 174,753,598 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2162,392,064 - 162,408,023 (+)NCBICelera
RGSC_v3.12174,694,725 - 174,703,904 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dabigatran  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diisopropyl fluorophosphate  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP)
gestodene  (ISO)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
heparin  (ISO)
hydrazine  (ISO)
icariin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP)
natamycin  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
norethisterone  (ISO)
norgestimate  (ISO)
nystatin  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinidine  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfasalazine  (ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
adaptive immune response  (IEA)
blood coagulation  (IEA,ISO)
blood coagulation, common pathway  (IBA,ISO)
blood coagulation, fibrin clot formation  (ISO)
cell-matrix adhesion  (ISO)
cellular response to granulocyte colony-stimulating factor  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
fibrinolysis  (IBA,ISO)
hemostasis  (IEA)
immune system process  (IEA)
induction of bacterial agglutination  (ISO)
innate immune response  (IEA)
liver regeneration  (IEP)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
plasminogen activation  (ISO)
platelet activation  (IEA)
platelet aggregation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of exocytosis  (ISO)
positive regulation of heterotypic cell-cell adhesion  (IBA,ISO)
positive regulation of peptide hormone secretion  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of smooth muscle cell migration  (IDA)
positive regulation of vasoconstriction  (ISO)
protein polymerization  (IEA,ISO)
protein-containing complex assembly  (ISO)
response to calcium ion  (ISO)
response to cycloheximide  (IEP)
response to estradiol  (IEP)
response to genistein  (IEP)
response to growth hormone  (IEP)
response to insulin  (IEP)
response to stress  (IEA)
response to thyroid hormone  (IEP)
response to toxic substance  (IEP)
response to X-ray  (IEP)
venom-mediated perturbation of blood coagulation  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Therapy with interleukin-22 alleviates hepatic injury and hemostasis dysregulation in rat model of acute liver failure. Ashour TH Adv Hematol. 2014;2014:705290. doi: 10.1155/2014/705290. Epub 2014 Apr 1.
2. Serum peptidome based biomarkers searching for monitoring minimal residual disease in adult acute lymphocytic leukemia. Bai J, etal., Proteome Sci. 2014 Sep 16;12(1):49. doi: 10.1186/s12953-014-0049-y. eCollection 2014.
3. Preliminary identification of differentially expressed tear proteins in keratoconus. Balasubramanian SA, etal., Mol Vis. 2013 Oct 30;19:2124-34. eCollection 2013.
4. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
5. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Benson MD, etal., Nat Genet. 1993 Mar;3(3):252-5.
6. Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia. Brennan SO, etal., Hepatology. 2002 Sep;36(3):652-8.
7. alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism. Carter AM, etal., Blood. 2000 Aug 1;96(3):1177-9.
8. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
9. Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice. Choi SA, etal., Mol Biol Rep. 2013 Feb;40(2):1753-65. doi: 10.1007/s11033-012-2229-0. Epub 2012 Oct 20.
10. Molecular cloning of cDNA for the alpha, beta, and gamma chains of rat fibrinogen. A family of coordinately regulated genes. Crabtree GR and Kant JA, J Biol Chem. 1981 Sep 25;256(18):9718-23.
11. Coordinate accumulation of the mRNAs for the alpha, beta, and gamma chains of rat fibrinogen following defibrination. Crabtree GR and Kant JA, J Biol Chem. 1982 Jul 10;257(13):7277-9.
12. Puerarin attenuates ovalbumin-induced lung inflammation and hemostatic unbalance in rat asthma model. Dong F, etal., Evid Based Complement Alternat Med. 2014;2014:726740. doi: 10.1155/2014/726740. Epub 2014 Jan 2.
13. Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters. Evans E, etal., J Biol Chem. 1987 Aug 5;262(22):10850-4.
14. The effects of sleep hypoxia on coagulant factors and hepatic inflammation in emphysematous rats. Feng J, etal., PLoS One. 2010 Oct 6;5(10):e13201. doi: 10.1371/journal.pone.0013201.
15. Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates. Fu Y, etal., Genomics 1995 Nov 1;30(1):71-6.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Effects of hypophysectomy of liver donor on net synthesis of specific plasma proteins by the isolated perfused rat liver. Modulation of synthesis of albumin, fibrinogen, alpha 1-acid glycoprotein, alpha 2-(acute phase)-globulin, and haptoglobin by insulin, cortisol, triiodothyronine, and growth hormone. Griffin EE and Miller LL, J Biol Chem. 1974 Aug 25;249(16):5062-9.
18. Enoxaparin attenuates endothelial damage with less bleeding compared with unfractionated heparin in endotoxemic rats. Iba T and Takayama T, Shock. 2009 Nov;32(5):530-4. doi: 10.1097/SHK.0b013e3181a2e279.
19. [Protective effects and anticoagulation effect of polysaccharides from the sea cucumber on acute incomplete cerebral ischemia in rats]. Jiang X, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):170-2.
20. Identification of potential biomarkers by serum proteomics analysis in rats with sepsis. Jiao J, etal., Shock. 2014 Jul;42(1):75-81. doi: 10.1097/SHK.0000000000000173.
21. Down-regulated expression of AQP5 on lung in rat DIC model induced by LPS and its effect on the development of pulmonary edema. Jin Y, etal., Pulm Pharmacol Ther. 2013 Dec;26(6):661-5. doi: 10.1016/j.pupt.2013.03.013. Epub 2013 Mar 26.
22. Effect of whole x-irradiation of rats on net synthesis of albumin, fibrinogen, alpha-1-acid glycoprotein, and alpha-2-globulin (acute phase globulin) by the isolated, perfused rat liver. John DW and Miller LL, J Biol Chem. 1968 Jan 25;243(2):268-73.
23. Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens. Kelly LA, etal., Thromb Haemost. 2010 Sep 13;104(6).
24. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells. Kim H, etal., Mol Cell Biol. 1998 Mar;18(3):1525-33.
25. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
26. Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Krishnamoorthy A, etal., Blood. 2011 Aug 18;118(7):1934-42. Epub 2011 Jun 17.
27. The fibrin-derived peptide bbeta15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury. Liu A, etal., Shock. 2013 Apr;39(4):397-403. doi: 10.1097/SHK.0b013e31828c2b75.
28. [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. Liu F, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Mar;30(3):190-3.
29. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
30. Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes. Lotta LA, etal., BMC Med Genomics. 2012 Feb 21;5(1):7.
31. Fibrinogen alpha-chain-derived peptide is upregulated in hippocampus of rats exposed to acute morphine injection and spontaneous alternation testing. Maki AE, etal., Pharmacol Res Perspect. 2014 Jun 1;2(3):e00037.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
34. A label-free nano-liquid chromatography-mass spectrometry approach for quantitative serum peptidomics in Crohn's disease patients. Nanni P, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3127-36. Epub 2009 Aug 7.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. The 11 kb FGA deletion responsible for congenital afibrinogenaemia is mediated by a short direct repeat in the fibrinogen gene cluster. Neerman-Arbez M, etal., Eur J Hum Genet. 1999 Dec;7(8):897-902.
37. Antiplatelet and antithrombotic effects of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y (SC-46749). Nicholson NS, etal., J Pharmacol Exp Ther. 1991 Mar;256(3):876-82.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. Distribution of mRNAS of fibrinogen polypeptides and albumin in free and membrane-bound polyribosomes and induction of alpha-fetoprotein mRNA synthesis during liver regeneration after partial hepatectomy. Princen HM, etal., Biochim Biophys Acta. 1982 Nov 30;699(2):121-30.
44. Cycloheximide as a probe of fibrinogen synthesis. Procyk R, etal., Biochem J. 1979 Feb 15;178(2):501-4.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Comprehensive gene review and curation RGD comprehensive gene curation
49. Molecular cloning of mRNA sequences transiently induced during rat liver regeneration. Sobczak J, etal., Exp Cell Res 1987 Mar;169(1):47-56.
50. Molecular basis of quantitative fibrinogen disorders in 27 patients from India. Sumitha E, etal., Haemophilia. 2013 Jul;19(4):611-8. doi: 10.1111/hae.12143. Epub 2013 Apr 8.
51. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Thukral SK, etal., Toxicol Pathol. 2005;33(3):343-55.
52. Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study. van Oijen M, etal., J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):799-803. Epub 2007 Oct 19.
53. Congenital afibrinogenaemia in a newborn infant due to a novel mutation in the fibrinogen aalpha gene. Vlietman JJ, etal., Br J Haematol. 2002 Oct;119(1):282-3.
54. Pre-treatment with bone marrow-derived mesenchymal stem cells inhibits systemic intravascular coagulation and attenuates organ dysfunction in lipopolysaccharide-induced disseminated intravascular coagulation rat model. Wang B, etal., Chin Med J (Engl). 2012 May;125(10):1753-9.
55. Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Wang C, etal., Thromb Res. 2013 Jan;131(1):e31-8. doi: 10.1016/j.thromres.2012.11.002. Epub 2012 Nov 28.
56. Defibrinogenating effect of batroxobin (Defibrase) in rats and inhibition of migration of human vascular smooth muscle cells by the plasma of batroxobin-treated rats in vitro. Wang DS, etal., Atherosclerosis. 2001 May;156(1):73-80.
57. Identification of novel biomarkers in seasonal allergic rhinitis by combining proteomic, multivariate and pathway analysis. Wang H, etal., PLoS One. 2011;6(8):e23563. Epub 2011 Aug 24.
58. Uncovering the protective mechanism of Huoxue Anxin Recipe against coronary heart disease by network analysis and experimental validation. Wang J, etal., Biomed Pharmacother. 2020 Jan;121:109655. doi: 10.1016/j.biopha.2019.109655. Epub 2019 Nov 14.
59. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
60. A novel nonsense mutation in the FGA gene in a Chinese family with congenital afibrinogenaemia. Wu S, etal., Blood Coagul Fibrinolysis. 2005 Apr;16(3):221-6.
Additional References at PubMed
PMID:6281794   PMID:6777381   PMID:8100742   PMID:8910396   PMID:9182580   PMID:10891444   PMID:10903502   PMID:10930441   PMID:12477932   PMID:12706644   PMID:15739255   PMID:15914557  
PMID:16452087   PMID:16846481   PMID:18676163   PMID:19056867   PMID:19193866   PMID:22516433   PMID:22819533   PMID:23376485   PMID:23382103   PMID:23533145   PMID:24367264   PMID:24769233  
PMID:27469290   PMID:29768263  


Genomics

Comparative Map Data
Fga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82170,672,169 - 170,679,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2170,672,012 - 170,679,577 (+)EnsemblGRCr8
mRatBN7.22168,374,120 - 168,381,523 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,374,120 - 168,381,528 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2175,564,269 - 175,571,651 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02173,585,204 - 173,592,586 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,186,618 - 168,194,000 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02181,997,562 - 182,013,726 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,006,242 - 182,013,763 (+)Ensemblrn6Rnor6.0
Rnor_5.02201,412,182 - 201,428,346 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42174,737,640 - 174,753,598 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2162,392,064 - 162,408,023 (+)NCBICelera
RGSC_v3.12174,694,725 - 174,703,904 (+)NCBI
Cytogenetic Map2q34NCBI
FGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,583,126 - 154,590,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4154,583,126 - 154,590,745 (-)Ensemblhg38GRCh38
GRCh374155,504,278 - 155,511,894 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,723,730 - 155,731,347 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344155,864,033 - 155,869,470NCBI
Celera4152,835,246 - 152,842,862 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4151,244,861 - 151,252,473 (-)NCBIHuRef
CHM1_14155,482,201 - 155,489,817 (-)NCBICHM1_1
T2T-CHM13v2.04157,914,895 - 157,922,551 (-)NCBIT2T-CHM13v2.0
Fga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,933,460 - 82,940,934 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,933,383 - 82,940,934 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38383,026,153 - 83,033,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,026,076 - 83,033,627 (+)Ensemblmm10GRCm38
MGSCv37382,830,075 - 82,837,549 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36383,112,081 - 83,118,197 (+)NCBIMGSCv36mm8
Celera383,030,275 - 83,037,743 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.96NCBI
Fga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,806,650 - 8,816,791 (+)Ensembl
ChiLan1.0NW_0049554718,806,964 - 8,814,671 (+)NCBIChiLan1.0ChiLan1.0
FGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23152,495,579 - 152,503,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,851,017 - 152,858,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,949,680 - 146,957,291 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14158,767,782 - 158,775,414 (-)NCBIPanPan1.1PanPan1.1panPan2
FGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,238,305 - 52,247,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,236,198 - 52,246,975 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1552,584,628 - 52,591,483 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01552,924,743 - 52,933,990 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,925,657 - 52,933,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,179,682 - 52,188,900 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,283,995 - 52,293,478 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,601,176 - 52,608,068 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,217,093 - 38,224,715 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,322,406 - 1,329,743 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365761,322,406 - 1,329,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,574,882 - 74,584,202 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1874,574,870 - 74,584,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,935,842 - 78,938,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,127,554 - 101,134,881 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,125,791 - 101,134,405 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603780,782,883 - 80,789,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248585,848,817 - 5,856,448 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fga
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1370,491,353 - 70,498,618 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fga
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:260
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000012192, ENSRNOT00000064091, ENSRNOT00000064150
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
D2Mit19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,377,888 - 168,378,009 (+)MAPPERmRatBN7.2
Rnor_6.02182,010,087 - 182,010,207NCBIRnor6.0
Rnor_5.02201,424,707 - 201,424,827UniSTSRnor5.0
RGSC_v3.42174,750,165 - 174,750,285UniSTSRGSC3.4
RGSC_v3.42174,750,164 - 174,750,285RGDRGSC3.4
Celera2162,404,589 - 162,404,709UniSTS
RGSC_v3.12174,700,270 - 174,700,391RGD
Cytogenetic Map2q34UniSTS
D2Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.42174,750,165 - 174,750,280UniSTSRGSC3.4
Celera2162,404,589 - 162,404,704UniSTS
Cytogenetic Map2 RGD
D2Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82170,675,845 - 170,676,187 (+)Marker Load Pipeline
mRatBN7.22168,377,796 - 168,378,138 (+)MAPPERmRatBN7.2
Rnor_6.02182,009,995 - 182,010,336NCBIRnor6.0
Rnor_5.02201,424,615 - 201,424,956UniSTSRnor5.0
RGSC_v3.42174,750,073 - 174,750,414UniSTSRGSC3.4
RGSC_v3.42174,750,072 - 174,750,414RGDRGSC3.4
Celera2162,404,497 - 162,404,838UniSTS
RGSC_v3.12174,700,178 - 174,700,520RGD
FHH x ACI Map275.4999RGD
FHH x ACI Map275.4999UniSTS
Cytogenetic Map2q34UniSTS
RH128930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,380,012 - 168,380,169 (+)MAPPERmRatBN7.2
Rnor_6.02182,012,211 - 182,012,367NCBIRnor6.0
Rnor_5.02201,426,831 - 201,426,987UniSTSRnor5.0
RGSC_v3.42174,752,289 - 174,752,445UniSTSRGSC3.4
Celera2162,406,713 - 162,406,869UniSTS
Cytogenetic Map2q34UniSTS
RH128215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,381,230 - 168,381,413 (+)MAPPERmRatBN7.2
Rnor_6.02182,013,429 - 182,013,611NCBIRnor6.0
Rnor_5.02201,428,049 - 201,428,231UniSTSRnor5.0
RGSC_v3.42174,753,507 - 174,753,689UniSTSRGSC3.4
Celera2162,407,931 - 162,408,113UniSTS
RH 3.4 Map21098.7UniSTS
Cytogenetic Map2q34UniSTS
GDB:633003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,379,056 - 168,379,466 (+)MAPPERmRatBN7.2
Rnor_6.02182,011,255 - 182,011,664NCBIRnor6.0
Rnor_5.02201,425,875 - 201,426,284UniSTSRnor5.0
RGSC_v3.42174,751,333 - 174,751,742UniSTSRGSC3.4
Celera2162,405,757 - 162,406,166UniSTS
Cytogenetic Map2q34UniSTS
D2Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,377,888 - 168,378,004 (+)MAPPERmRatBN7.2
Rnor_6.02182,010,087 - 182,010,202NCBIRnor6.0
Rnor_5.02201,424,707 - 201,424,822UniSTSRnor5.0
RGSC_v3.42174,750,165 - 174,750,280UniSTSRGSC3.4
Celera2162,404,589 - 162,404,704UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 9 30 93 88 85 59 28 59 6 230 77 75 79 70 26

Sequence


Ensembl Acc Id: ENSRNOT00000064091   ⟹   ENSRNOP00000060007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2170,672,012 - 170,679,566 (+)Ensembl
mRatBN7.2 Ensembl2168,374,120 - 168,381,528 (+)Ensembl
Rnor_6.0 Ensembl2182,006,242 - 182,013,763 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094522   ⟹   ENSRNOP00000088145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2170,673,754 - 170,679,577 (+)Ensembl
mRatBN7.2 Ensembl2168,375,705 - 168,381,528 (+)Ensembl
RefSeq Acc Id: NM_001008724   ⟹   NP_001008724
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82170,672,169 - 170,679,572 (+)NCBI
mRatBN7.22168,374,120 - 168,381,523 (+)NCBI
Rnor_6.02181,997,562 - 182,013,521 (+)NCBI
Rnor_5.02201,412,182 - 201,428,346 (+)NCBI
RGSC_v3.42174,737,640 - 174,753,598 (+)RGD
Celera2162,392,064 - 162,408,023 (+)NCBI
Sequence:
RefSeq Acc Id: NM_052797   ⟹   NP_434684
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82170,672,187 - 170,678,237 (+)NCBI
mRatBN7.22168,374,138 - 168,380,188 (+)NCBI
Rnor_6.02182,006,336 - 182,012,386 (+)NCBI
Rnor_5.02201,412,182 - 201,428,346 (+)NCBI
RGSC_v3.42174,737,640 - 174,753,598 (+)RGD
Celera2162,400,838 - 162,406,888 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001008724   ⟸   NM_001008724
- Peptide Label: isoform 1 precursor
- UniProtKB: P06399 (UniProtKB/Swiss-Prot),   A0A9K3Y6Z7 (UniProtKB/TrEMBL),   D3ZJ95 (UniProtKB/TrEMBL),   Q7TQ70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_434684   ⟸   NM_052797
- Peptide Label: isoform 2 precursor
- UniProtKB: A1L114 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060007   ⟸   ENSRNOT00000064091
Ensembl Acc Id: ENSRNOP00000088145   ⟸   ENSRNOT00000094522
Protein Domains
Fibrinogen alpha C   Fibrinogen alpha/beta/gamma chain coiled coil   Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06399-F1-model_v2 AlphaFold P06399 1-782 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691396
Promoter ID:EPDNEW_R1921
Type:multiple initiation site
Name:Fga_1
Description:fibrinogen alpha chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02182,006,318 - 182,006,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2603 AgrOrtholog
BioCyc Gene G2FUF-52662 BioCyc
Ensembl Genes ENSRNOG00000024848 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064091 ENTREZGENE
Gene3D-CATH 1.20.5.50 UniProtKB/Swiss-Prot
  3.90.215.10 UniProtKB/Swiss-Prot
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7371484 IMAGE-MGC_LOAD
  IMAGE:8375711 IMAGE-MGC_LOAD
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_coil_dom UniProtKB/Swiss-Prot
  Fibrinogen_aC UniProtKB/Swiss-Prot
  Fibrinogen_alpha UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:112792 IMAGE-MGC_LOAD
  MGC:156536 IMAGE-MGC_LOAD
NCBI Gene Fga ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
  PTHR47221 UniProtKB/Swiss-Prot
Pfam Fib_alpha UniProtKB/Swiss-Prot
  Fibrinogen_aC UniProtKB/Swiss-Prot
  Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Fga PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000024848 RatGTEx
SMART FBG UniProtKB/Swiss-Prot
  Fib_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP Fibrinogen coiled-coil and central regions UniProtKB/Swiss-Prot
  SSF56496 UniProtKB/Swiss-Prot
UniProt A0A8I6A5L4_RAT UniProtKB/TrEMBL
  A0A9K3Y6Z7 ENTREZGENE, UniProtKB/TrEMBL
  A1L114 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJ95 ENTREZGENE
  FIBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4G044_RAT UniProtKB/TrEMBL
  Q7TQ70 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Fga  fibrinogen alpha chain  Fga  fibrinogen, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Fga  Fibrinogen, A alpha polypeptide      Symbol and Name status set to approved 70586 APPROVED