RGD Reference Report - [Experimental anticoagulant therapy of acute lung injury induced by paraquat]. - Rat Genome Database

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[Experimental anticoagulant therapy of acute lung injury induced by paraquat].

Authors: Liu, Feng  Jian, Xiang-dong  Zhang, Zhong-chen  Liu, Hui-min  Zhou, Qian  Zhang, Wei  Shang, Bo  Tian, Dong  Niu, Yan-ying  Bi, Yan-qun  Jiang, Jian 
Citation: Liu F, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Mar;30(3):190-3.
RGD ID: 7387313
Pubmed: PMID:22804886   (View Abstract at PubMed)


OBJECTIVE: To establish a model of acute lung injury induced by paraquat poisoning and to observe the effects of anticoagulant therapy on acute lung injury induced by paraquat poisoning.
METHODS: One hundred twenty adult healthy male Wistar rats were randomly divided into three groups: the paraquat poisoning group was exposed intragastrically (IG) to 50 mg/kg paraquat, anticoagulant therapy group was exposed intragastrically (IG) to 50 mg/kg paraquat then administrated subcutaneously with 68 U/kg low molecular heparin calcium 2 times a day and administrated intragastrically with 1.67 mg/kg aspirin one tome a day for 3, 7, 14 and 21 days, respectively, control group exposed intragastrically to normal saline. After exposure the rats were sacrificed, the venous blood and lung tissues were collected to detect the prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin time and D-dimer in blood and the hydroxyproline in lung tissues, and to examine pathological changes in lung tissues with HE and Masson staining under light microscope.
RESULTS: At the 3rd, 7th, 14th and 21st days after exposure, the hydroxyproline contents of lung tissues in paraquat poisoning group and anticoagulation therapy group were significantly higher than those in control group (P < 0.05), but the hydroxyproline contents of lung tissues in anticoagulation therapy group were significantly lower than those in paraquat poisoning group (P < 0.05). At the 3rd day after exposure, the PT, APTT, Fib and D-dimer levels in paraquat poisoning group and anticoagulation therapy group were significantly higher than those in control group (P < 0.05), the D-dimer level of anticoagulation therapy group was significantly lower than that of control group (P < 0.05). At the 7th, 14th and 21st days after exposure, the TT and D-dimer levels of paraquat poisoning group and anticoagulation therapy group were significantly higher than those of control group (P < 0.05), the TT and D-dimer levels of anticoagulation therapy group were significantly lower than those of paraquat poisoning group (P < 0.05). The lung injury in paraquat poisoning group increased with exposure period, the lung fibrosis in anticoagulation therapy group was lower than that in paraquat poisoning group.
CONCLUSION: Anticoagulation therapy can improve hyper-coagulation state and acute lung injury in rats induced by paraquat poisoning.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Acute Lung Injury  IDA 7387313 RGD 
Acute Lung Injury  ISOF2 (Rattus norvegicus)7387313; 7387313 RGD 
Acute Lung Injury  ISOFga (Rattus norvegicus)7387313; 7387313protein:increased expression:blood (rat)RGD 
Acute Lung Injury  IEP 7387313protein:increased expression:blood (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II, thrombin)
Fga  (fibrinogen alpha chain)

Genes (Mus musculus)
F2  (coagulation factor II)
Fga  (fibrinogen alpha chain)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)
FGA  (fibrinogen alpha chain)


Additional Information