RGD Reference Report - Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice.

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Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice.
Authors:	Choi, SA Yun, JW Park, HS Choi, JW
Citation:	Choi SA, etal., Mol Biol Rep. 2013 Feb;40(2):1753-65. doi: 10.1007/s11033-012-2229-0. Epub 2012 Oct 20.
RGD ID:	9684989
Pubmed:	PMID:23086277 (View Abstract at PubMed)
DOI:	DOI:10.1007/s11033-012-2229-0 (Journal Full-text)
The proteins in plasma perform many important functions in the body, and the protein profiles of the plasma vary under different physiological and pathological conditions. In an attempt to identify novel marker proteins for diabetes prognosis, we examined the effect of hypoglycemic dipeptide cyclo (His-Pro) (CHP) on the differential regulation of plasma proteins in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice. The orally-administrated CHP produced an excellent hypoglycemic effect in both animal models, lowering the average plasma glucose level by over 50 %. In the 2-DE analysis of the plasma, a total of 23 spots among 500 visualized spots were found to be differentially regulated, and they were identified by MALDI/TOF mass spectrometry. These proteins include the down-regulation of Apo E and the up-regulation of FGA, Apo A-I, Apo A-IV, and A1M in STZ-induced diabetic rats. Moreover, CHP significantly reduced the plasma protein levels of FGB, FGC, F12, C1QTNF5, and SPA3K, as well as increased the abundance of A1M, A2M, Apo E, and TTR in genetically-diabetic mice. In conclusion, alteration in the regulation of these proteins indicates that this treatment may be successful in overcoming the diabetic state. The present proteomic data can serve as the basis for the development of specific evidence-based interventions allowing for the prevention and treatment of diabetes.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
FGA	Human	Experimental Diabetes Mellitus		ISO	Fga (Rattus norvegicus)	protein:increased expression:plasma (rat)	RGD
Fga	Rat	Experimental Diabetes Mellitus		IEP		protein:increased expression:plasma (rat)	RGD
Fga	Mouse	Experimental Diabetes Mellitus		ISO	Fga (Rattus norvegicus)	protein:increased expression:plasma (rat)	RGD

Objects Annotated

Genes (Rattus norvegicus)

Fga (fibrinogen alpha chain)

Genes (Mus musculus)

Fga (fibrinogen alpha chain)

Genes (Homo sapiens)

FGA (fibrinogen alpha chain)

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Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice.