RGD Reference Report - The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. - Rat Genome Database

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The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats.

Authors: Bekyarova, G  Tancheva, S  Hristova, M 
Citation: Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
RGD ID: 5131457
Pubmed: PMID:20664819   (View Abstract at PubMed)
DOI: DOI:10.1358/mf.2010.32.5.1437717   (Journal Full-text)

The aim of this study was to investigate the effects of melatonin on burn-induced inflammatory responses and coagulation disorders in a rat model. Under ether anesthesia, shaved dorsa of rats were exposed to 90 degrees C for 10 s to induce burn injury. Melatonin (10 mg/kg) was administered immediately and after 12 h. Standard coagulation tests (prothrombin activity [PA] and activated partial thromboplastin time [aPTT]), platelet number and morphology; proinflammatory markers (C-reactive protein [CRP] and fibrinogen) and lipid peroxidation marker (malondialdehyde [MDA]) levels were assayed. Thermal injury increased the levels of MDA (by 76%, P < 0.0001), CRP (by 33%, P < 0.0001), fibrinogen (4.5-fold, P < 0.0001) and PA (by 37%; P < 0.01). Changes in aPTT and platelet numbers were nonsignificant. Melatonin diminished the elevated CRP and fibrinogen levels, normalized MDA levels, platelet morphology and decreased PA. A positive association of MDA with fibrinogen and MDA with PA were noted after melatonin treatment. To conclude, melatonin as an antioxidant and anti-inflammatory agent exerted a suppressive effect on burn-induced disorders in blood coagulation and might be useful in the prevention of disseminated intravascular microthrombosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Burns  ISOCrp (Rattus norvegicus)5131457; 5131457 RGD 
Burns  IEP 5131457 RGD 
Burns  ISOFga (Rattus norvegicus)5131457; 5131457protein:increased expression:plasma (rat)RGD 
Burns  IEP 5131457protein:increased expression:plasma (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)
Fga  (fibrinogen alpha chain)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)
Fga  (fibrinogen alpha chain)

Genes (Homo sapiens)
CRP  (C-reactive protein)
FGA  (fibrinogen alpha chain)


Additional Information