Gene:	Ikbkb ( Rattus norvegicus ) inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Description:	kinase that may be involved in megakaryocyte polyploidization
Synonyms:	AIM-1; inhibitor of kappaB kinase beta; IKK2;
ArrayIDs:	6054888; 6454861; 5771121; A_43_P12782; 6179846; rc_AI137901_at; 5642121; 6646948; 6259687; 5983396; 6570977; 1368424_at; 5674955; 6528789; 5781233; 6452673; 6660879; 5670807; GE13357; rc_AI179234_at; 6697156; 6679720; GE1293200; 6287389; 6716401; 5970842; 1397547_at; 6322327; 6696617; 5646116; 5948872; 6739161; 6359577; 6181669;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: IKBKB     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ikbkb     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ikbkb genome assembly 3.1 16 73805346 - 73858348     Rat Celera Assembly 16 67214377 - 67265924     RGSC genome assembly v3.4 16 73805082 - 73858086     Cytogenetic 16 q12.5 Mus musculus Ikbkb Mouse genome assembly build 36.1 8 23770235 - 23817035     Cytogenetic 8 8 A3-A4 Homo sapiens IKBKB human genome assembly 8 42247985 - 42309122     Human genome assembly build 36.2 8 42247986 - 42309122     Cytogenetic 8 p11.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53   Gene Ontology protein kinase activity,  nucleotide binding,  kinase activity ...  (details...)
Biological Process	Note Reference regulates growth 70526 forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation   Gene Ontology response to toxin,  B cell homeostasis,  skeletal muscle contraction ...  (details...)
Cellular Component	Gene Ontology IkappaB kinase complex,  cytoplasm,  microsome ...  (details...)
Expression	Note Reference expressed in megakaryocytes 633167 expressed in rat liver and spleen cells 70526
Pathway	Ontology tumor necrosis factor mediated signaling pathway,  nuclear factor kappa B signaling pathway (details...)
Regulation	Note Reference forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation 70526
Physical interaction	Note Reference cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53 70526
External Links
Databases	DATABASE ID SOURCE PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI000012D469 IPI UNIPARC: UPI0000DC106C IPI KEGG Report: rno:84351 ENTREZGENE HomoloGene Group ID: 7782 ENTREZGENE Germonline: 621375 Pfam: Pkinase IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04622 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Kinase-like_dom. IPI IPI: IPI00213608 IPI IPI: IPI00782738 IPI Ensembl Protein: ENSRNOP00000025851 IPI Ensembl Protein: ENSRNOP00000054991 IPI Entrez Gene: Ikbkb ENTREZGENE UniProt: IKKB_RAT IPI Ensembl Genes: ENSRNOG00000019073 IPI Superfamily-SCOP: Kinase_like IPI
Sequences	Nucleotide: AF115282 Get FASTA Search GEO Profiles Nucleotide: CH473970 Get FASTA Search GEO Profiles Nucleotide: CB810812 Get FASTA Search GEO Profiles Nucleotide: CO383061 Get FASTA Search GEO Profiles Nucleotide: NM_053355 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: NP_445807 Get FASTA Protein: EDM09011 Get FASTA Protein: EDM09012 Get FASTA Protein: AAF21978 Get FASTA Protein: Q9QY78 Get FASTA (View all 5 Protein Accessions)
Clusters	UniGene: 19222
References
Curated References	14 references in RGD related to Ikbkb
Other References	19 other references at PubMed related to Ikbkb
Database Information
RGD ID	621375
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 26-FEB-09: Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Ikbkb inhibitor of kappaB kinase beta APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-JAN-05: Ikbkb inhibitor of kappaB kinase beta inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta APPROVED Name updated 1299863 07-AUG-02: Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta PROVISIONAL Symbol and Name status set to provisional 70820