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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbincreases phosphorylationEXP 6480464CTDsodium arsenite results in increased phosphorylation of IKBKB proteinPMID:19616567
Ikbkbmultiple interactionsEXP 6480464CTDPS1145 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]; Taurine inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]PMID:19616567
Ikbkbaffects expressionISOIKBKB (Homo sapiens)6480464CTDsodium arsenite affects the expression of IKBKB mRNA; sodium arsenite affects the expression of IKBKB proteinPMID:29528074
Ikbkbaffects response to substanceISOIKBKB (Homo sapiens)6480464CTDIKBKB affects the susceptibility to sodium arsenitePMID:20810208
Ikbkbdecreases expressionISOIkbkb (Mus musculus)6480464CTDsodium arsenite results in decreased expression of IKBKB mRNAPMID:31233874
Ikbkbincreases activityISOIKBKB (Homo sapiens)6480464CTDsodium arsenite results in increased activity of IKBKB proteinPMID:23069812
Ikbkbmultiple interactionsISOIkbkb (Mus musculus)6480464CTD[TRP53 gene mutant form affects the susceptibility to sodium arsenite] which results in decreased phosphorylation of IKBKB proteinPMID:29944914
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