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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbdecreases activityISOIKBKB (Homo sapiens)6480464CTDCurcumin results in decreased activity of IKBKB proteinPMID:16023083 PMID:16219905
Ikbkbdecreases activityISOIkbkb (Mus musculus)6480464CTDCurcumin results in decreased activity of IKBKB proteinPMID:16678799
Ikbkbmultiple interactionsISOIKBKB (Homo sapiens)6480464CTDCurcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]PMID:16219905 PMID:17965732 PMID:23452621 PMID:29793316
Ikbkbmultiple interactionsISOIkbkb (Mus musculus)6480464CTDCurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]PMID:20054000
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