GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ikbkb | affects response to substance | ISO | Ikbkb (Mus musculus) | 6480464 | CTD | IKBKB protein affects the susceptibility to Etoposide | PMID:20159942 | Ikbkb | decreases expression | ISO | IKBKB (Homo sapiens) | 6480464 | CTD | Etoposide results in decreased expression of IKBKB protein | PMID:30177839 | Ikbkb | multiple interactions | ISO | IKBKB (Homo sapiens) | 6480464 | CTD | DAPK1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; ETS1 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein]; IKBKB protein inhibits the reaction [Etoposide results in increased expression of GADD45A protein]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein modified form]; IKBKB protein promotes the reaction [Etoposide results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [Etoposide results in decreased expression of IKBKB protein] | PMID:30177839 | | ||||||||||||||||||||||
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