Mmp2 (matrix metallopeptidase 2) - Rat Genome Database

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Gene: Mmp2 (matrix metallopeptidase 2) Rattus norvegicus
Analyze
Symbol: Mmp2
Name: matrix metallopeptidase 2
RGD ID: 621316
Description: Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in extracellular space. Used to study artery disease (multiple); conjunctivitis; proteinuria; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2); PARTICIPATES IN syndecan signaling pathway; gonadotropin-releasing hormone signaling pathway; urinary bladder cancer pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 72 kDa gelatinase; 72 KDa type IV collagenase; gelatinase A; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase-2; MMP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mmp2em2Mcwi  
Genetic Models: SS-Mmp2em1Mcwi-/- SS-Mmp2em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,327,643 - 30,355,856 (-)NCBIGRCr8
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mmp2Ratabdominal aortic aneurysm treatmentIEP 8657104 RGD 
Mmp2Ratabdominal aortic aneurysm treatmentIDA 13207313 RGD 
Mmp2Ratabdominal aortic aneurysm  IEP 2325698 RGD 
Mmp2Ratabdominal aortic aneurysm  IEP 1302825 RGD 
Mmp2Ratabdominal aortic aneurysm no_associationISOMMP2 (Homo sapiens)1582621 RGD 
Mmp2Ratabdominal aortic aneurysm  IDA 1582579 RGD 
Mmp2RatAcute Lung Injury  IEP 13207316 RGD 
Mmp2Ratacute necrotizing pancreatitis  IEP 7207204mRNA:increased expression:pancreas (rat)RGD 
Mmp2RatAcute Otitis Media  ISOMmp2 (Mus musculus)127284853mRNA:increased expression:middle ear (mouse)RGD 
Mmp2Ratadrenoleukodystrophy  ISOMMP2 (Homo sapiens)13204814protein:increased expression:cerebrospinal fluidRGD 
Mmp2Ratalcohol use disorder  IEP 13207311 RGD 
Mmp2RatAlveolar Bone Loss treatmentIEP 329956421associated with periodontal diseaseRGD 
Mmp2RatAlzheimer's disease  ISOMMP2 (Homo sapiens)10059680protein:decreased expression:plateletRGD 
Mmp2Ratamyotrophic lateral sclerosis severityISOMMP2 (Homo sapiens)7207054protein:increased expression:serum and cerebrospinal fluid (human)RGD 
Mmp2Ratamyotrophic lateral sclerosis  ISOMmp2 (Mus musculus)13204793protein:increased expression:skin of body and spinal cordRGD 
Mmp2RatAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  ISOMMP2 (Homo sapiens)7207083protein:increased activity:urine (human)RGD 
Mmp2Rataortic dissection treatmentISOMmp2 (Mus musculus)156420156Apolipoprotein E knockoutRGD 
Mmp2Rataortic valve disease 2  ISOMMP2 (Homo sapiens)13204802protein:increased expression:serumRGD 
Mmp2Ratarteriosclerosis  ISOMMP2 (Homo sapiens)1582580 RGD 
Mmp2RatArteriovenous Fistula  IEP 1642040protein:increased expression:ileal veinRGD 
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Mmp2RatChromosome 16q12 Duplication Syndrome  ISOMMP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868 and PMID:33891002
Mmp2Ratgenetic disease  ISOMMP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21421877 more ...
Mmp2Rathead and neck squamous cell carcinoma  ISOMMP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Lip and oral cavity carcinomaClinVarPMID:28595731
Mmp2RatJoubert syndrome 1  ISOMMP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:17558409 and PMID:28492532
Mmp2RatOsteolysis Hereditary Multicentric  ISOMMP2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10356396 more ...
Mmp2RatWinchester syndrome  ISOMMP2 (Homo sapiens)8554872ClinVar Annotator: match by term: Winchester-Grossman syndromeClinVarPMID:11431697 more ...
1 to 20 of 49 rows
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Mmp2Ratalcoholic liver cirrhosis  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23274713
Mmp2Rataortic disease  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15545515
Mmp2RatAortic Rupture  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18178469
Mmp2Ratbone disease  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17440987
Mmp2RatBone Neoplasms  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16475674
Mmp2RatBreast Neoplasms  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18398872 and PMID:18507500
Mmp2Ratcalcinosis  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15545515 and PMID:21193197
Mmp2RatCerebral Hemorrhage  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10698078
Mmp2Ratcerebral infarction  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16846501
Mmp2RatChemical and Drug Induced Liver Injury  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15763341
Mmp2RatColorectal Neoplasms  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18507500 and PMID:21278247
Mmp2RatCraniofacial Abnormalities  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17400654 and PMID:17440987
Mmp2Ratcutaneous leishmaniasis  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21091666
Mmp2Ratdiabetic neuropathy  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20213226
Mmp2RatDisease Progression  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22321834
Mmp2RatExperimental Diabetes Mellitus  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21963884
Mmp2RatExperimental Liver Cirrhosis  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15095483 and PMID:25380136
Mmp2RatExperimental Liver Neoplasms  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30603057
Mmp2RatExperimental Mammary Neoplasms  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28574600
Mmp2Ratextrahepatic cholestasis  ISOMMP2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
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Mmp2RatOsteolysis Hereditary Multicentric  ISOMMP2 (Homo sapiens)7240710 OMIM 

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Mmp2Rat(+)-Tetrandrine multiple interactionsISOMMP2 (Homo sapiens)6480464tetrandrine results in decreased expression of and results in decreased activity of MMP2 proteinCTDPMID:30549224
Mmp2Rat(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] more ...CTDPMID:17481882
Mmp2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMMP2 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of MMP2 protein]CTDPMID:31252129
Mmp2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMmp2 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]CTDPMID:20438794
Mmp2Rat(1->4)-beta-D-glucan multiple interactionsISOMmp2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of MMP2 mRNACTDPMID:36331819
Mmp2Rat(20S)-ginsenoside Rg3 multiple interactionsISOMMP2 (Homo sapiens)6480464ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of MMP2 protein] and ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]CTDPMID:24793912
Mmp2Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNACTDPMID:23830814
Mmp2Rat(R)-noradrenaline multiple interactionsISOMMP2 (Homo sapiens)6480464Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] more ...CTDPMID:24929186
Mmp2Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of MMP2 mRNACTDPMID:14577597 more ...
Mmp2Rat(R)-noradrenaline increases activityEXP 6480464Norepinephrine results in increased activity of MMP2 proteinCTDPMID:16864425
Mmp2Rat(R)-noradrenaline multiple interactionsEXP 6480464Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] more ...CTDPMID:14577597 more ...
Mmp2Rat(R)-noradrenaline increases expressionISOMMP2 (Homo sapiens)6480464Norepinephrine results in increased expression of MMP2 mRNACTDPMID:24929186
Mmp2Rat(S)-naringenin multiple interactionsISOMMP2 (Homo sapiens)6480464naringenin results in decreased expression of and results in decreased activity of MMP2 proteinCTDPMID:30431227
Mmp2Rat(S)-naringenin decreases expressionISOMMP2 (Homo sapiens)6480464naringenin results in decreased expression of MMP2 mRNACTDPMID:30153467
Mmp2Rat(S)-nicotine multiple interactionsISOMmp2 (Mus musculus)6480464[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNACTDPMID:33091441
Mmp2Rat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of MMP2 mRNACTDPMID:34153408
Mmp2Rat(S)-nicotine decreases expressionISOMmp2 (Mus musculus)6480464Nicotine results in decreased expression of MMP2 proteinCTDPMID:20448088
Mmp2Rat(S)-nicotine increases expressionISOMMP2 (Homo sapiens)6480464Nicotine results in increased expression of MMP2 mRNA and Nicotine results in increased expression of MMP2 proteinCTDPMID:14569062 more ...
Mmp2Rat(S)-nicotine multiple interactionsISOMMP2 (Homo sapiens)6480464lipopolysaccharide more ...CTDPMID:18986645
Mmp2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOMMP2 (Homo sapiens)6480464o and p'-DDT results in increased expression of MMP2 mRNACTDPMID:26225806

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Biological Process
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Original Reference(s)
Mmp2Ratangiogenesis  IEP 625663 RGD 
Mmp2Ratangiogenesis involved_inIEAUniProtKB-KW:KW-00371600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratblood vessel maturation acts_upstream_of_or_withinIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratblood vessel maturation acts_upstream_of_or_withinISOMmp2 (Mus musculus)1624291MGI:1855698 PMID:11747814RGDPMID:11747814
Mmp2Ratbone trabecula formation acts_upstream_of_or_withinISOMmp2 (Mus musculus)1624291MGI:88467 PMID:17440987RGDPMID:17440987
Mmp2Ratbone trabecula formation acts_upstream_of_or_withinIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratcell migration  IMP 2325687 RGD 
Mmp2Ratcell migration involved_inIEAUniProtKB:P08253 and ensembl:ENSP000002190701600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratcell migration involved_inISOMMP2 (Homo sapiens)1624291 PMID:31879982RGDPMID:31879982
Mmp2Ratcellular response to amino acid stimulus acts_upstream_of_or_withinISOMmp2 (Mus musculus)1624291 PMID:20548288RGDPMID:20548288
Mmp2Ratcellular response to amino acid stimulus acts_upstream_of_or_withinIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratcellular response to cytokine stimulus  IEP 2325816 RGD 
Mmp2Ratcellular response to estradiol stimulus  IMP 2325711 RGD 
Mmp2Ratcellular response to fluid shear stress  IEP 7207287 RGD 
Mmp2Ratcellular response to interleukin-1  IEP 2325687 RGD 
Mmp2Ratcellular response to interleukin-1  IEP 2313720Il-1betaRGD 
Mmp2Ratcellular response to reactive oxygen species acts_upstream_of_or_withinISOMmp2 (Mus musculus)1624291 PMID:17561096RGDPMID:17561096
Mmp2Ratcellular response to reactive oxygen species acts_upstream_of_or_withinIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratcellular response to UV-A involved_inISSUniProtKB:P082531600115GO_REF:0000024UniProtGO_REF:0000024
Mmp2Ratcellular response to UV-A involved_inISOMMP2 (Homo sapiens)1624291 PMID:31380578RGDPMID:31380578
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Cellular Component
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Mmp2Ratextracellular matrix located_inIEAInterPro:IPR001818 and InterPro:IPR0211581600115GO_REF:0000002InterProGO_REF:0000002
Mmp2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratextracellular space  IDA 8657085 RGD 
Mmp2Ratextracellular space is_active_inIBAPANTHER:PTN002565758 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp2Ratextracellular space located_inIEAUniProtKB:P08253 and ensembl:ENSP000002190701600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratextracellular space located_inISOMMP2 (Homo sapiens)1624291 PMID:18492766 more ...RGDPMID:18492766 more ...
Mmp2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Mmp2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Mmp2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratplasma membrane located_inIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratplasma membrane located_inISOMmp2 (Mus musculus)1624291 PMID:17349656RGDPMID:17349656
Mmp2Ratsarcomere located_inIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratsarcomere located_inISOMmp2 (Mus musculus)1624291 PMID:17349656RGDPMID:17349656
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Molecular Function
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Mmp2Ratendopeptidase activity enablesISOMMP2 (Homo sapiens)1624291 PMID:23845380RGDPMID:23845380
Mmp2Ratendopeptidase activity enablesIEAUniProtKB:P08253 and ensembl:ENSP000002190701600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratfibronectin binding  IPIFn1 (Rattus norvegicus)2296060 RGD 
Mmp2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratmetalloendopeptidase activity enablesIEAEC:3.4.24.241600115GO_REF:0000003UniProtGO_REF:0000003
Mmp2Ratmetalloendopeptidase activity enablesISOMmp2 (Mus musculus)1624291 PMID:12419962 and PMID:15212943RGDPMID:12419962 and PMID:15212943
Mmp2Ratmetalloendopeptidase activity enablesIEAUniProtKB:P33434 and ensembl:ENSMUSP000000341871600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratmetalloendopeptidase activity enablesIEAInterPro:IPR001818 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mmp2Ratmetalloendopeptidase activity enablesIBAFB:FBgn0033438 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mmp2Ratmetallopeptidase activity  TAS 70539 RGD 
Mmp2Ratmetallopeptidase activity enablesIEAUniProtKB:P08253 and ensembl:ENSP000002190701600115GO_REF:0000107EnsemblGO_REF:0000107
Mmp2Ratmetallopeptidase activity enablesIEAInterPro:IPR006026 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mmp2Ratmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratmetallopeptidase activity enablesISOMMP2 (Homo sapiens)1624291 PMID:24236012 and PMID:31879982RGDPMID:24236012 and PMID:31879982
Mmp2Ratpeptidase activity  IDA 7207198collagenaseRGD 
Mmp2Ratpeptidase activity enablesIEAARBA:ARBA000274081600115GO_REF:0000117UniProtGO_REF:0000117
Mmp2Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Mmp2Ratpeptidase activity  IDA 4142798 RGD 
Mmp2Ratpeptidase activity  IDA 2325681 RGD 
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Imported Annotations - KEGG (archival)

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Mmp2Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Mmp2Raturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219

Imported Annotations - PID (archival)

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Mmp2Ratsyndecan signaling pathway  ISOMMP2 (Homo sapiens)6484113 PIDPID:200192
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Mmp2Ratabnormal podocyte physiology amelioratesIMP 401827835associated with Experimental Diabetes Mellitus and compared to wild type SSRGD 
Mmp2Ratdecreased circulating creatinine level  IMP 401827835compared to wild type SSRGD 
Mmp2Ratdecreased kidney weight  IMP 401827835associated Experimental Diabetes Mellitus more ...RGD 
Mmp2Ratdecreased transforming growth factor beta level  IMP 401827835compared to wild type SSRGD 
Mmp2Ratdecreased urine protein level  IMP 401827835compared to wild type SSRGD 
Mmp2Ratdecreased vascular permeability amelioratesIMP 401827835associated with Experimental Diabetes Mellitus and compared to wild type SSRGD 
Mmp2Ratglomerulosclerosis amelioratesIMP 401827835compared to wild type SSRGD 
Mmp2Ratincreased renal glomerular filtration rate  IMP 401827835compared to wild type SSRGD 
Mmp2Ratrenal interstitial fibrosis amelioratesIMP 401827835compared to wild type SSRGD 
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Reference Title
Reference Citation
1. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Abdul-Muneer PM, etal., Brain Behav Immun. 2017 Jan;59:190-199. doi: 10.1016/j.bbi.2016.09.002. Epub 2016 Sep 7.
2. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
3. Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
4. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Alfonso-Jaume MA, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1838-46. Epub 2006 May 12.
5. Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. Alsac JM, etal., Eur J Vasc Endovasc Surg. 2011 Apr;41(4):474-80. doi: 10.1016/j.ejvs.2010.12.007. Epub 2011 Jan 20.
6. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
7. Upregulated expression and activation of membrane‑associated proteases in esophageal squamous cell carcinoma. Augoff K, etal., Oncol Rep. 2014 Jun;31(6):2820-6. doi: 10.3892/or.2014.3162. Epub 2014 Apr 29.
8. Insidious role of nitric oxide in migration/invasion of colon cancer cells by upregulating MMP-2/9 via activation of cGMP-PKG-ERK signaling pathways. Babykutty S, etal., Clin Exp Metastasis. 2012 Jun;29(5):471-92. doi: 10.1007/s10585-012-9464-6. Epub 2012 Mar 15.
9. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Barichello T, etal., Exp Biol Med (Maywood). 2014 Feb;239(2):225-31. doi: 10.1177/1535370213508354. Epub 2014 Jan 13.
10. Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia-reperfusion. Barlaka E, etal., Can J Physiol Pharmacol. 2013 Aug;91(8):608-16. doi: 10.1139/cjpp-2012-0412. Epub 2013 Mar 3.
11. The involvement of oxidants and NF-kappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Ben-David D, etal., Inflamm Res. 2012 Jul;61(7):673-88. doi: 10.1007/s00011-012-0461-7. Epub 2012 Mar 13.
12. Genetic variations and plasma levels of gelatinase A (matrix metalloproteinase-2) and gelatinase B (matrix metalloproteinase-9) in proliferative diabetic retinopathy. Beranek M, etal., Mol Vis. 2008 Jun 14;14:1114-21.
13. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Bergman MR, etal., Biochem J 2003 Feb 1;369(Pt 3):485-96.
14. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. Bhattacharyya SS, etal., Zhong Xi Yi Jie He Xue Bao. 2010 Jul;8(7):645-54.
15. Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium. Bogusiewicz M, etal., Gynecol Endocrinol. 2007 Sep;23(9):541-6.
16. Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are prognostic factors in cervical cancer, related to invasive disease but not to high-risk human papillomavirus (HPV) or virus persistence after treatment of CIN. Branca M, etal., Anticancer Res. 2006 Mar-Apr;26(2B):1543-56.
17. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
18. MMP-2 regulates rat ventral prostate development in vitro. Bruni-Cardoso A, etal., Dev Dyn. 2010 Mar;239(3):737-46.
19. Stromal remodelling is required for progressive involution of the rat ventral prostate after castration: Identification of a matrix metalloproteinase-dependent apoptotic wave. Bruni-Cardoso A, etal., Int J Androl. 2009 Nov 10.
20. Vascular extracellular matrix remodeling in cerebral aneurysms. Bruno G, etal., J Neurosurg. 1998 Sep;89(3):431-40.
1 to 20 of 255 rows
1 to 10 of 28 rows
PMID:11747814   PMID:11824471   PMID:11824476   PMID:12419962   PMID:12477932   PMID:12617792   PMID:12747454   PMID:12970340   PMID:14512418   PMID:15038770   PMID:15051632   PMID:15052653  
PMID:15075185   PMID:15212943   PMID:15255544   PMID:15269222   PMID:15300910   PMID:15480899   PMID:15509661   PMID:15522203   PMID:15609629   PMID:15615723   PMID:15621209   PMID:15637127  
PMID:15652546   PMID:15655118   PMID:15728709   PMID:15793858   PMID:15802562   PMID:15863497   PMID:15956706   PMID:16047157   PMID:16097048   PMID:16148033   PMID:16200464   PMID:16337314  
PMID:16377938   PMID:16484357   PMID:16575906   PMID:16680016   PMID:16680367   PMID:16690877   PMID:16707552   PMID:16707787   PMID:16738242   PMID:16815061   PMID:16816895   PMID:16854986  
PMID:16951163   PMID:17008622   PMID:17028444   PMID:17064783   PMID:17122420   PMID:17143608   PMID:17158653   PMID:17188498   PMID:17308006   PMID:17332085   PMID:17349656   PMID:17382917  
PMID:17428795   PMID:17440987   PMID:17496904   PMID:17505812   PMID:17561096   PMID:17607299   PMID:17644578   PMID:17684756   PMID:17854826   PMID:17903365   PMID:17960656   PMID:17986262  
PMID:17987394   PMID:18000599   PMID:18031717   PMID:18052689   PMID:18071296   PMID:18075836   PMID:18247145   PMID:18264108   PMID:18279587   PMID:18293392   PMID:18320202   PMID:18327702  
PMID:18332633   PMID:18347835   PMID:18354258   PMID:18403250   PMID:18415800   PMID:18433461   PMID:18436234   PMID:18492766   PMID:18509851   PMID:18556655   PMID:18562481   PMID:18580857  
PMID:18615687   PMID:18667463   PMID:18668563   PMID:18675881   PMID:18678246   PMID:18765931   PMID:18769934   PMID:18814268   PMID:18836702   PMID:18846548   PMID:18935914   PMID:18983773  
PMID:19041098   PMID:19052882   PMID:19076167   PMID:19085832   PMID:19132994   PMID:19148693   PMID:19184368   PMID:19189315   PMID:19248829   PMID:19258038   PMID:19259351   PMID:19272247  
1 to 10 of 28 rows



Mmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81930,327,643 - 30,355,856 (-)NCBIGRCr8
mRatBN7.21914,154,657 - 14,182,870 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1915,850,377 - 15,877,927 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01921,045,167 - 21,072,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01923,990,811 - 24,019,370 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,542,771 - 15,570,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,629,728 - 26,658,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41915,246,036 - 15,275,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1914,077,766 - 14,105,839 (-)NCBICelera
Cytogenetic Map19p11NCBI
MMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381655,478,830 - 55,506,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1655,389,700 - 55,506,691 (+)EnsemblGRCh38hg38GRCh38
GRCh371655,512,742 - 55,540,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,070,589 - 54,098,104 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,070,603 - 54,097,652NCBI
Celera1640,027,315 - 40,054,814 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1641,400,533 - 41,427,983 (+)NCBIHuRef
CHM1_11656,920,344 - 56,947,845 (+)NCBICHM1_1
T2T-CHM13v2.01661,276,956 - 61,304,813 (+)NCBIT2T-CHM13v2.0
Mmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,553,920 - 93,580,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl893,553,919 - 93,580,048 (+)EnsemblGRCm39 Ensembl
GRCm38892,827,290 - 92,853,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl892,827,291 - 92,853,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37895,351,227 - 95,377,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36895,716,456 - 95,742,548 (+)NCBIMGSCv36mm8
Celera897,157,107 - 97,183,318 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.99NCBI
Mmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543313,024,418 - 13,052,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543313,024,844 - 13,050,041 (+)NCBIChiLan1.0ChiLan1.0
MMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21864,904,348 - 64,934,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11670,825,738 - 70,852,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01635,711,866 - 35,738,881 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11654,817,228 - 54,844,279 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1654,812,694 - 54,844,279 (+)Ensemblpanpan1.1panPan2
MMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1260,471,092 - 60,492,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl260,471,257 - 60,494,113 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha257,105,772 - 57,130,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,016,206 - 61,041,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,016,193 - 61,041,733 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,844,808 - 57,869,825 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,869,067 - 58,894,067 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,747,357 - 59,772,363 (-)NCBIUU_Cfam_GSD_1.0
Mmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934951,763,246 - 51,787,737 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364757,801,277 - 7,825,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364757,801,356 - 7,825,831 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl630,058,595 - 30,086,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1630,059,247 - 30,087,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2627,526,396 - 27,553,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6p15-p14NCBI
MMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,264,382 - 41,291,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl541,264,354 - 41,291,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604735,055,095 - 35,082,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247571,448,698 - 1,479,255 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247571,450,680 - 1,479,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Mmp2
298 total Variants

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000022679
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat

1 to 10 of 21 rows
RH130872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,154,763 - 14,154,951 (+)MAPPERmRatBN7.2
Rnor_6.01915,542,878 - 15,543,065NCBIRnor6.0
Rnor_5.01926,629,835 - 26,630,022UniSTSRnor5.0
RGSC_v3.41915,246,143 - 15,246,330UniSTSRGSC3.4
Celera1914,077,873 - 14,078,060UniSTS
Cytogenetic Map19p11UniSTS
PMC18111P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21914,154,843 - 14,154,993 (+)MAPPERmRatBN7.2
Rnor_6.01915,542,958 - 15,543,107NCBIRnor6.0
Rnor_5.01926,629,915 - 26,630,064UniSTSRnor5.0
RGSC_v3.41915,246,223 - 15,246,372UniSTSRGSC3.4
Celera1914,077,953 - 14,078,102UniSTS
Cytogenetic Map19p11UniSTS


This gene Mmp2 is modified in the following models/strains:
SS-Mmp2em1Mcwi-/-     SS-Mmp2em2Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022679   ⟹   ENSRNOP00000022679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)Ensembl
Rnor_6.0 Ensembl1915,542,765 - 15,570,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100137   ⟹   ENSRNOP00000077106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1914,154,657 - 14,182,870 (-)Ensembl
RefSeq Acc Id: NM_031054   ⟹   NP_112316
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81930,327,643 - 30,355,856 (-)NCBI
mRatBN7.21914,154,657 - 14,182,870 (-)NCBI
Rnor_6.01915,542,771 - 15,570,589 (-)NCBI
Rnor_5.01926,629,728 - 26,658,966 (-)NCBI
RGSC_v3.41915,246,036 - 15,275,061 (-)RGD
Celera1914,077,766 - 14,105,839 (-)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_112316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB41692 (Get FASTA)   NCBI Sequence Viewer  
  AAF71618 (Get FASTA)   NCBI Sequence Viewer  
  AAH74013 (Get FASTA)   NCBI Sequence Viewer  
  ABI97027 (Get FASTA)   NCBI Sequence Viewer  
  EDL87568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022679
  ENSRNOP00000022679.7
GenBank Protein P33436 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_112316   ⟸   NM_031054
- Peptide Label: precursor
- UniProtKB: P97581 (UniProtKB/Swiss-Prot),   Q6GMM9 (UniProtKB/Swiss-Prot),   P33436 (UniProtKB/Swiss-Prot),   A6KD58 (UniProtKB/TrEMBL),   E9PSM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022679   ⟸   ENSRNOT00000022679
Ensembl Acc Id: ENSRNOP00000077106   ⟸   ENSRNOT00000100137
Fibronectin type-II

Name Modeler Protein Id AA Range Protein Structure
AF-P33436-F1-model_v2 AlphaFold P33436 1-662 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700969
Promoter ID:EPDNEW_R11492
Type:initiation region
Name:Mmp2_2
Description:matrix metallopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11493  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,570,510 - 15,570,570EPDNEW
RGD ID:13700970
Promoter ID:EPDNEW_R11493
Type:initiation region
Name:Mmp2_1
Description:matrix metallopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11492  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01915,570,614 - 15,570,674EPDNEW


1 to 40 of 56 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-6398 BioCyc
Ensembl Genes ENSRNOG00000016695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022679 ENTREZGENE
  ENSRNOT00000022679.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.10.10 UniProtKB/Swiss-Prot
  2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100171 IMAGE-MGC_LOAD
InterPro FN_type2_dom UniProtKB/Swiss-Prot
  FN_type2_sf UniProtKB/Swiss-Prot
  Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  Hemopexin_CS UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:81686 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91653 IMAGE-MGC_LOAD
NCBI Gene 81686 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  PTHR10201:SF29 UniProtKB/Swiss-Prot
Pfam fn2 UniProtKB/Swiss-Prot
  Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
PhenoGen Mmp2 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS FNTYPEII UniProtKB/Swiss-Prot
  MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  FN2_1 UniProtKB/Swiss-Prot
  FN2_2 UniProtKB/Swiss-Prot
  HEMOPEXIN UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
1 to 40 of 56 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mmp2  matrix metallopeptidase 2    matrix metalloproteinase 2 (72 KDa type IV collagenase)  Name updated 1299863 APPROVED
2002-08-07 Mmp2        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease upregulated in vascular diseases with advanced aging 70546
gene_disease highly expressed in experimental models of ventricular failure and in cardiac extracts from patients with ischaemic cardiomyopathy 629541
gene_disease high expression correlates with hepatic fibrosis, chronic glomerulosclerosis, neoangiogenesis and distal metastasis formation 628551
gene_disease increased expression is observed in rheumatoid arthiritis and periodontal disease, highly expressed in patients with ulcerative colitis 628551
gene_expression present in the brain gray matter 70539
gene_expression expressed in aortic cells 70546
gene_expression expressed in the colonic wall tissue of colotic and normal rats 628551
gene_function zinc and calcium-dependent endopeptidase, secreted as a zymogen 625578
gene_function zinc and calcium-dependent endopeptidase, secreted as a zymogen 628551
gene_process has a role in vascular disease remodeling, tumor invasion and facilitates SMC migration 70546
gene_process degrades type IV collagen and gelatine 628551
gene_process involved in tissue destruction and remodelling 628551
gene_process palys a role in extracellular matrix proteolysis and increased cell invasiveness in many cell types including endothelial cells 625663
gene_process plays a role in growth, angiogenesis, and extracellular matrix turnover; can degrade multiple components of basement membranes, including type IV and V collagens and laminin 625578
gene_product member of zinc-binding proteinases 629541
gene_protein 72 kDa 629541
gene_regulation expression in neoplastic cells is regulated by the combinatorial interactions of p53, activating Protein-2, and YB-1 with a single enhancer element 628551
gene_regulation released by several cells in response to inflammatory cytokines such as interleukin-1 and tumor necrosis factor-alpha 628551
gene_regulation protein level increases during muscle stretch but not after shear stress activation and is independent of VEGF signaling 628551
gene_regulation expression regulated by gene transcription, mRNA stability, activation of proenzyme and inhibition/activation of enzyme through the tissue inhibitors of metalloproteinases 628551
gene_regulation after exposure of cultured cardiac fibroblasts to IL-1 beta, expression was enhanced in cells of both SHR and WKY strains to equivalent levels as measured by both semiquantitative PCR and zymographic studies 1358958