RGD Reference Report - Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. - Rat Genome Database

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Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection.

Authors: Akiyama, M  Ohtani, H  Sato, E  Nagura, H  Tabayashi, K 
Citation: Akiyama M, etal., Virchows Arch. 2006 Jun;448(6):811-21. Epub 2006 Apr 12.
RGD ID: 1582568
Pubmed: PMID:16609908   (View Abstract at PubMed)
DOI: DOI:10.1007/s00428-006-0194-5   (Journal Full-text)

The pathophysiological significance of matrix metalloproteinases (MMPs) in aortic dissection remains poorly understood. The purpose of the present study is to clarify the significance of MMPs in aortic dissection. The activities and distributions of MMP-2, membrane-type 1-MMP (MT1-MMP), and MMP-9 were evaluated by gelatin zymography, immunohistochemistry, and in situ hybridization in 29 patients and seven autopsy cases. To assess if these MMPs are related to a tissue remodeling process, we compared the expression of these MMPs with that of type I procollagen and platelet-derived growth factor receptor beta chain (PDGF Rbeta). Patients were divided into three groups based on histological findings: acute, intermediate, and healed groups. The most remarkable changes were observed in the intermediate group, in which MMP-2 activity peaked and tissue expression of mRNAs for MMP-2 and MT1-MMP were observed in spindle-shaped cells in the neointima, organizing thrombus, and the adventitia. These expression patterns were essentially coupled with those of type I procollagen mRNA and PDGF-Rbeta protein. The association of MMP-2, MT1-MMP, type I procollagen, and PDGF-Rbeta suggests that MMP-2 and MT1-MMP could be involved not only in the degradation of aortic tissue but also in tissue remodeling, which may be associated with the healing process.

Objects referenced in this article
Gene MMP14 matrix metallopeptidase 14 Homo sapiens
Gene MMP2 matrix metallopeptidase 2 Homo sapiens
Gene Mmp14 matrix metallopeptidase 14 (membrane-inserted) Mus musculus
Gene Mmp2 matrix metallopeptidase 2 Mus musculus
Gene Mmp14 matrix metallopeptidase 14 Rattus norvegicus
Gene Mmp2 matrix metallopeptidase 2 Rattus norvegicus

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