RGD Reference Report - Matrix metalloproteinases and their inhibitors in different acute stroke subtypes. - Rat Genome Database

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Matrix metalloproteinases and their inhibitors in different acute stroke subtypes.

Authors: Vukasovic, I  Tesija-Kuna, A  Topic, E  Supanc, V  Demarin, V  Petrovcic, M 
Citation: Vukasovic I, etal., Clin Chem Lab Med. 2006;44(4):428-34.
RGD ID: 1582617
Pubmed: PMID:16599837   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2006.079   (Journal Full-text)

The aim of the study was to determine serum levels of selected matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs) in the acute phase of different stroke types subdivided according to the Oxfordshire Community Stroke Project (OCSP) classification and the possibility of discriminating stroke types according to their levels. The study included 126 patients with acute stroke within the first 24 h of symptom onset, and 124 healthy volunteers. The stroke group had lower MMP-2 concentrations and MMP-2/TIMP-2 ratios (p<0.001) but higher TIMP-2 (p<0.001) than controls. The level of MMP-9 and the MMP-9/TIMP-1 ratio were higher in patients with total anterior circulation infarct (TACI) than in patients with other stroke subtypes according to OCSP classification (p=0.0019, p=0.0065, respectively) or in controls (p<0.0001, p=0.0024, respectively). A negative correlation of MMP-2 levels with MMP-9 and MMP-9/TIMP-1 ratio was recorded in all stroke subtypes except for TACI. Receiver operating characteristic analysis showed similar discriminating power for MMP-9 levels and Barthel index in the differential diagnosis of TACI. High MMP-9/TIMP-1 ratio (odds ratio 3.263) was associated with TACI. Our results demonstrate that the MMP-9/TIMP-1 ratio may provide information to help in assessing stroke patients in the future as a baseline biomarker of infarct extent.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain infarction  IEP 1582617 RGD 
brain infarction  ISOMMP9 (Homo sapiens)1582617; 1582617 RGD 
Stroke  IEP 1582617 RGD 
Stroke  ISOMMP2 (Homo sapiens)1582617; 1582617 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp2  (matrix metallopeptidase 2)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp2  (matrix metallopeptidase 2)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP2  (matrix metallopeptidase 2)
MMP9  (matrix metallopeptidase 9)


Additional Information