RGD Reference Report - Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. - Rat Genome Database

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Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia.

Authors: Hosomi, N  Nishiyama, A  Ban, CR  Naya, T  Takahashi, T  Kohno, M  Koziol, JA 
Citation: Hosomi N, etal., Neuroscience. 2005;134(1):225-31.
RGD ID: 1582577
Pubmed: PMID:15963646   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2005.03.054   (Journal Full-text)

Following cerebral ischemia, i.v. infusion of angiotensin II increases cerebral edema and mortality. Angiotensin type 1 receptor blockage should therefore improve acute cerebral ischemia. Left middle cerebral artery occlusion (120 min) followed by reperfusion was performed with the thread method under halothane anesthesia in Sprague-Dawley rats. Olmesartan (angiotensin type 1 receptor blocker; 0.01 or 0.1mumol/kg/h) was infused i.p. for 7 days following middle cerebral artery occlusion followed by reperfusion. Stroke index score, infarct volume, specific gravity, and brain angiotensin II and matrix metalloproteinases were quantified in the ischemic and non-ischemic hemispheres. Olmesartan treatment improved stroke index score, infarct volume, and cerebral edema in our cerebral ischemia model. In particular, stroke index score, infarct volume, and cerebral edema were reduced even with a low dose of olmesartan that did not decrease blood pressure. Paralleling these effects on cerebral ischemia, olmesartan treatment also reduced the reactive upregulation in brain angiotensin II, matrix metalloproteinase-2, matrix metalloproteinase-9, and membrane type 1-matrix metalloproteinase in the ischemic area. Angiotensin type 1 receptor stimulation may be one of the important factors that cause cerebral edema following cerebral ischemia, and that its inhibition may be of therapeutic advantage in cerebral ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  ISOMmp14 (Rattus norvegicus)1582577; 1582577 RGD 
brain ischemia  ISOMmp2 (Rattus norvegicus)1582577; 1582577 RGD 
brain ischemia  IEP 1582577; 1582577 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp14  (matrix metallopeptidase 14)
Mmp2  (matrix metallopeptidase 2)

Genes (Mus musculus)
Mmp14  (matrix metallopeptidase 14 (membrane-inserted))
Mmp2  (matrix metallopeptidase 2)

Genes (Homo sapiens)
MMP14  (matrix metallopeptidase 14)
MMP2  (matrix metallopeptidase 2)


Additional Information