RGD Reference Report - Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure. - Rat Genome Database

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Imbalance of matrix metalloproteinases/tissue inhibitor of metalloproteinase-1 and loss of fibronectin expression in patients with congestive heart failure.

Authors: Yang, DC  Ma, ST  Tan, Y  Chen, YH  Li, D  Tang, B  Chen, JS  Su, XH  Li, G  Zhang, X  Yang, YJ 
Citation: Yang DC, etal., Cardiology. 2010;116(2):133-41. doi: 10.1159/000317245. Epub 2010 Jul 1.
RGD ID: 8694112
Pubmed: PMID:20606426   (View Abstract at PubMed)
DOI: DOI:10.1159/000317245   (Journal Full-text)

OBJECTIVE: Previous studies have demonstrated that an imbalance of matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinase-1 (TIMP-1) and a loss of fibronectin are associated with postmyocardial infarction remodeling in rats. The present study was designed to examine this issue in patients with congestive heart failure (CHF). METHODS: We measured plasma levels and the cardiac protein expression of MMPs/TIMP-1 and fibronectin in 39 patients with CHF and 38 controls. RESULTS: Plasma levels of MMP-2, MMP-3, and MMP-9 tended to be higher in patients with CHF (NYHA II: 276 +/- 18, 613 +/- 118, and 245 +/- 43 microg/l, respectively; NYHA III: 302 +/- 20, 850 +/- 132, and 310 +/- 39 microg/l, respectively; NYHA IV: 367 +/- 15, 998 +/- 99, and 392 +/- 27 microg/l, respectively) than in controls (213 +/- 23, 485 +/- 102, and 158 +/- 31 microg/l, respectively), while the plasma TIMP-1 level tended to be lower in patients with CHF (NYHA II: 126 +/- 12 microg/l, NYHA III: 83 +/- 11 microg/l, and NYHA IV: 61 +/- 12 microg/l) than in controls (208 +/- 15 microg/l). Interestingly, the changes in protein expression of MMPs/TIMP-1 were consistent with their plasma concentration. Furthermore, the fibronectin level in the patients with CHF was significantly lower than in the controls. Conclusions: These data suggest that human CHF is associated with an imbalance of MMPs/TIMP-1 and a concurrent loss of fibronectin.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
congestive heart failure  IEP 8694112; 8694112; 8694112protein:increased expression:heart left ventricle and plasmaRGD 
congestive heart failure  ISOMMP2 (Homo sapiens)8694112; 8694112protein:increased expression:heart left ventricle and plasmaRGD 
congestive heart failure  ISOMMP3 (Homo sapiens)8694112; 8694112protein:increased expression:heart left ventricle and plasmaRGD 
congestive heart failure  ISOMMP9 (Homo sapiens)8694112; 8694112protein:increased expression:heart left ventricle and plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mmp2  (matrix metallopeptidase 2)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Mus musculus)
Mmp2  (matrix metallopeptidase 2)
Mmp3  (matrix metallopeptidase 3)
Mmp9  (matrix metallopeptidase 9)

Genes (Homo sapiens)
MMP2  (matrix metallopeptidase 2)
MMP3  (matrix metallopeptidase 3)
MMP9  (matrix metallopeptidase 9)


Additional Information