Hes1 (hes family bHLH transcription factor 1) - Rat Genome Database

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Gene: Hes1 (hes family bHLH transcription factor 1) Rattus norvegicus
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Symbol: Hes1
Name: hes family bHLH transcription factor 1
RGD ID: 62081
Description: Enables several functions, including JUN kinase binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of gene expression; and regulation of gliogenesis. Located in chromatin and nuclear matrix. Used to study chronic myeloid leukemia and epilepsy. Biomarker of acute kidney failure. Orthologous to human HES1 (hes family bHLH transcription factor 1); PARTICIPATES IN Notch signaling pathway; maturity-onset diabetes of the young pathway; Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hairy and enhancer of split 1; hairy and enhancer of split 1 (Drosophila); hairy and enhancer of split 1, (Drosophila); hairy-like protein; RHL; transcription factor HES-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,210,632 - 84,213,045 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1184,210,633 - 84,213,061 (-)EnsemblGRCr8
mRatBN7.21170,705,763 - 70,708,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,705,764 - 70,708,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,549,796 - 79,552,209 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,184,221 - 72,186,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,238,898 - 71,241,311 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1169,677,011 - 69,679,422 (-)NCBICelera
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-methylfuran  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (ISO)
aconitine  (EXP,ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (EXP)
baicalein  (ISO)
baicalin  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Crenigacestat  (EXP,ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
DAPT  (EXP,ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (EXP,ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
galactose  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
HT-2 toxin  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
juglone  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mebendazole  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
naled  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nirogacestat  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
Paeonol  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
Salidroside  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (EXP)
Tiron  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-caffeic acid  (EXP)
triadimefon  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenohypophysis development  (ISO)
anterior/posterior pattern specification  (IBA)
aorta morphogenesis  (IEA,ISO)
artery morphogenesis  (IEA,ISO)
ascending aorta morphogenesis  (IEA,ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cell adhesion  (ISO)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell migration  (ISO)
cell morphogenesis involved in neuron differentiation  (ISO)
cellular response to fatty acid  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to nerve growth factor stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
cochlea development  (ISO)
comma-shaped body morphogenesis  (IEA,ISO)
common bile duct development  (ISO)
DNA-templated transcription  (IEA)
embryonic heart tube morphogenesis  (IEA,ISO)
establishment of epithelial cell polarity  (ISO)
forebrain radial glial cell differentiation  (IDA)
glomerulus vasculature development  (IEA,ISO)
hair cell differentiation  (IMP)
hindbrain morphogenesis  (ISO)
in utero embryonic development  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
labyrinthine layer blood vessel development  (IEA,ISO)
lateral inhibition  (ISO)
liver development  (ISO)
lung development  (ISO)
metanephric nephron tubule morphogenesis  (IEA,ISO)
midbrain development  (ISO)
midbrain-hindbrain boundary morphogenesis  (ISO)
negative regulation of calcium ion import  (IMP)
negative regulation of cell differentiation  (ISO)
negative regulation of cell fate determination  (ISO)
negative regulation of DNA-templated transcription  (IDA,IEA,ISO)
negative regulation of forebrain neuron differentiation  (IDA)
negative regulation of gene expression  (IMP)
negative regulation of glial cell proliferation  (IEA,ISO,ISS)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of inner ear receptor cell differentiation  (IEA,ISO)
negative regulation of neurogenesis  (IMP)
negative regulation of neuron differentiation  (IBA,ISO)
negative regulation of neuron projection development  (IMP)
negative regulation of oligodendrocyte differentiation  (IEA,IMP,ISO,ISS)
negative regulation of pancreatic A cell differentiation  (ISO)
negative regulation of pro-B cell differentiation  (IEA,ISO,ISS)
negative regulation of stem cell differentiation  (IEA,ISO)
negative regulation of stomach neuroendocrine cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
neural tube development  (ISO)
neuron differentiation  (IEP)
neuronal stem cell population maintenance  (IDA,IEA,ISO)
Notch signaling pathway  (IBA,IEA,ISO)
oculomotor nerve development  (ISO)
outflow tract morphogenesis  (ISO)
pancreas development  (ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
pituitary gland development  (ISO)
positive regulation of astrocyte differentiation  (IEA,ISO,ISS)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of glial cell differentiation  (IMP)
positive regulation of mitotic cell cycle, embryonic  (IEA,ISO)
positive regulation of Notch signaling pathway  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
positive regulation of T cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO,ISS)
protein-containing complex assembly  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (ISO)
regulation of fat cell differentiation  (ISO)
regulation of neurogenesis  (IBA,ISO)
regulation of protein-containing complex assembly  (IDA)
regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
regulation of secondary heart field cardioblast proliferation  (ISO)
regulation of timing of cell differentiation  (ISO)
regulation of timing of neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
renal interstitial fibroblast development  (IEA,ISO)
response to alkaloid  (IEP)
response to Aroclor 1254  (IEP)
response to thyroid hormone  (IEP)
response to virus  (ISO)
S-shaped body morphogenesis  (IEA,ISO)
smoothened signaling pathway  (ISO)
somatic stem cell population maintenance  (ISO)
telencephalon development  (ISO)
thymus development  (IEA,ISO)
trochlear nerve development  (ISO)
ureteric bud morphogenesis  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA,ISO)
ventricular septum development  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
chromatin  (IDA)
cytoplasm  (IEA,ISO)
nuclear matrix  (IDA)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs). Bansal R, etal., Brain Res Dev Brain Res. 2005 Apr 21;156(1):13-22.
2. A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. Feder JN, etal., Mol Cell Biol 1993 Jan;13(1):105-13.
3. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
4. The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Fisher AL, etal., Mol Cell Biol. 1996 Jun;16(6):2670-7.
5. rax, Hes1, and notch1 promote the formation of Muller glia by postnatal retinal progenitor cells. Furukawa T, etal., Neuron 2000 May;26(2):383-94.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. Grbavec D and Stifani S, Biochem Biophys Res Commun. 1996 Jun 25;223(3):701-5.
8. [Effect of fermented cordyceps powder and prednisone on the Notch2/Hes-1 signaling activation in the kidney tubules of rats with acute aristolochic acid nephropathy]. Huang RF, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Aug;33(8):1116-21.
9. HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Iso T, etal., Mol Cell Biol. 2001 Sep;21(17):6080-9.
10. Neural cell adhesion molecule-mediated neurite outgrowth is repressed by overexpression of HES-1. Jessen U, etal., J Neurosci Res 2003 Jan 1;71(1):1-6.
11. Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Ju BG, etal., Cell. 2004 Dec 17;119(6):815-29.
12. Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. Katakura M, etal., Neuroscience. 2009 May 19;160(3):651-60. doi: 10.1016/j.neuroscience.2009.02.057. Epub 2009 Mar 9.
13. Arecoline N-oxide regulates oral squamous cell carcinoma development through NOTCH1 and FAT1 expressions. Kuo TM, etal., J Cell Physiol. 2019 Aug;234(8):13984-13993. doi: 10.1002/jcp.28084. Epub 2019 Jan 9.
14. JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1. Lin CH and Lee EH, J Neurosci. 2012 Feb 1;32(5):1826-46. doi: 10.1523/JNEUROSCI.3380-11.2012.
15. Genetically engineered bone marrow mesenchymal stem cells improve functional outcome in a rat model of epilepsy. Long Q, etal., Brain Res. 2013 Sep 26;1532:1-13. doi: 10.1016/j.brainres.2013.07.020. Epub 2013 Aug 6.
16. The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1. McLarren KW, etal., J Biol Chem. 2000 Jan 7;275(1):530-8.
17. Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. McLarren KW, etal., J Biol Chem. 2001 Jan 12;276(2):1578-84.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
20. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Nakahara F, etal., Blood. 2010 Apr 8;115(14):2872-81. doi: 10.1182/blood-2009-05-222836. Epub 2009 Oct 27.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons. Ohtsuka T, etal., Cell Tissue Res. 1998 Jul;293(1):23-9.
23. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. Ohtsuka T, etal., J Biol Chem. 2001 Aug 10;276(32):30467-74. Epub 2001 Jun 8.
24. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Sasai Y, etal., Genes Dev 1992 Dec;6(12B):2620-34.
29. Determination of relative Notch1 and gamma-secretase-related gene expression in puromycin-treated microdissected rat kidneys. Simic D, etal., Gene Expr. 2013;16(1):39-47.
30. Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation. Strom A, etal., Genes Dev. 1997 Dec 1;11(23):3168-81.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. Wang H, etal., J Biol Chem. 2013 Jun 7;288(23):16761-74. doi: 10.1074/jbc.M112.446633. Epub 2013 Apr 15.
33. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, etal., Neuroscience. 2015 Aug 20;301:276-88. doi: 10.1016/j.neuroscience.2015.06.002. Epub 2015 Jun 8.
34. Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Wu Y, etal., Dev Dyn. 2003 Apr;226(4):675-89.
35. Emodin alleviates hypertrophic scar formation by suppressing macrophage polarization and inhibiting the Notch and TGF-β pathways in macrophages. Xia Z, etal., Braz J Med Biol Res. 2021 Jul 23;54(8):e11184. doi: 10.1590/1414-431X2021e11184. eCollection 2021.
36. Effects of matrine on oval cellmediated liver regeneration and expression of RBPJkappa and HES1. Yang ZY, etal., Mol Med Rep. 2013 May;7(5):1533-8. doi: 10.3892/mmr.2013.1398. Epub 2013 Mar 27.
37. The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. Yao J, etal., Mol Cell Biol. 2001 Mar;21(6):1962-72.
38. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. You J, etal., J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. doi: 10.1097/FJC.0b013e31827a0278.
39. The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. Zhang Y, etal., J Cell Biochem. 2009 Oct 15;108(3):651-9. doi: 10.1002/jcb.22299.
40. Hes1 is a negative regulator of inner ear hair cell differentiation. Zheng JL, etal., Development. 2000 Nov;127(21):4551-60.
41. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
Additional References at PubMed
PMID:8543157   PMID:10205173   PMID:10615124   PMID:10804175   PMID:10851137   PMID:10952889   PMID:11260262   PMID:11425898   PMID:11500373   PMID:12032823   PMID:12208538   PMID:12477932  
PMID:12488457   PMID:12535671   PMID:14764602   PMID:15060169   PMID:15156153   PMID:15465493   PMID:15489334   PMID:15496443   PMID:15578515   PMID:15645444   PMID:15821257   PMID:15870295  
PMID:16038893   PMID:16160079   PMID:16201968   PMID:16314515   PMID:16335396   PMID:16489008   PMID:17015435   PMID:17079689   PMID:17426285   PMID:17681138   PMID:18173746   PMID:18302773  
PMID:18579678   PMID:18996108   PMID:19050759   PMID:19124651   PMID:19609448   PMID:19619492   PMID:19682396   PMID:19840854   PMID:20122914   PMID:20628571   PMID:21259317   PMID:21300049  
PMID:21332343   PMID:22334042   PMID:22521826   PMID:22960268   PMID:22989188   PMID:23284756   PMID:23595520   PMID:24098462   PMID:24270810   PMID:24300895   PMID:24927445   PMID:25431316  
PMID:25535395   PMID:25624721   PMID:28689657   PMID:29750292   PMID:30107165   PMID:31454988   PMID:31476403   PMID:37445785   PMID:37543138  


Genomics

Comparative Map Data
Hes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81184,210,632 - 84,213,045 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1184,210,633 - 84,213,061 (-)EnsemblGRCr8
mRatBN7.21170,705,763 - 70,708,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,705,764 - 70,708,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1179,549,796 - 79,552,209 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01172,184,221 - 72,186,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01171,238,898 - 71,241,311 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01174,312,837 - 74,315,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)Ensemblrn6Rnor6.0
Rnor_5.01177,360,109 - 77,362,521 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,603,482 - 72,605,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1169,677,011 - 69,679,422 (-)NCBICelera
RGSC_v3.11172,661,439 - 72,663,801 (-)NCBI
Cytogenetic Map11q22NCBI
HES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383194,136,148 - 194,138,732 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3194,136,142 - 194,138,732 (+)Ensemblhg38GRCh38
GRCh373193,853,937 - 193,856,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363195,336,628 - 195,339,090 (+)NCBIBuild 36Build 36hg18NCBI36
Celera3192,270,388 - 192,272,854 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3191,241,261 - 191,243,734 (+)NCBIHuRef
CHM1_13193,816,827 - 193,819,297 (+)NCBICHM1_1
T2T-CHM13v2.03196,832,819 - 196,835,403 (+)NCBIT2T-CHM13v2.0
Hes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,883,259 - 29,886,614 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,883,202 - 29,886,614 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381630,065,357 - 30,067,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1630,064,384 - 30,067,796 (+)Ensemblmm10GRCm38
MGSCv371630,065,443 - 30,067,882 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361629,985,104 - 29,987,543 (+)NCBIMGSCv36mm8
Celera1630,572,496 - 30,574,749 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.09NCBI
Hes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,564,283 - 14,568,447 (-)Ensembl
ChiLan1.0NW_00495542014,565,921 - 14,568,447 (-)NCBIChiLan1.0ChiLan1.0
HES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22192,057,229 - 192,060,673 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13192,062,515 - 192,065,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03191,432,513 - 191,435,387 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13201,749,044 - 201,751,591 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,749,044 - 201,754,257 (+)EnsemblpanPan2panpan1.1
HES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2352,257,121 - 52,259,752 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02353,157,666 - 53,160,303 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2353,153,934 - 53,160,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,667,374 - 52,670,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,721,885 - 52,724,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02353,007,809 - 53,010,447 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hes1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,607,220 - 123,609,806 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936711639,905 - 642,622 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936711640,002 - 642,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13131,135,725 - 131,138,237 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113131,135,970 - 131,137,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,633,207 - 140,635,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11588,220,093 - 88,222,563 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1588,220,083 - 88,223,243 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604161,888,842 - 61,891,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,563,754 - 63,566,781 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473063,563,848 - 63,566,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hes1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1414,946,704 - 14,949,676 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hes1
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:187
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000002346
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
Hes1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,705,834 - 70,706,235 (+)MAPPERmRatBN7.2
Rnor_6.01174,312,909 - 74,313,309NCBIRnor6.0
Rnor_5.01177,360,181 - 77,360,581UniSTSRnor5.0
RGSC_v3.41172,603,554 - 72,603,954UniSTSRGSC3.4
Celera1169,677,081 - 69,677,481UniSTS
Cytogenetic Map11q22UniSTS
UniSTS:259614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,706,517 - 70,707,894 (+)MAPPERmRatBN7.2
Rnor_6.01174,313,592 - 74,314,967NCBIRnor6.0
Rnor_5.01177,360,864 - 77,362,239UniSTSRnor5.0
RGSC_v3.41172,604,237 - 72,605,391UniSTSRGSC3.4
Celera1169,677,764 - 69,679,140UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 89 59 6 353 189 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002346   ⟹   ENSRNOP00000002346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1184,210,633 - 84,213,061 (-)Ensembl
mRatBN7.2 Ensembl1170,705,764 - 70,708,192 (-)Ensembl
Rnor_6.0 Ensembl1174,312,806 - 74,315,248 (-)Ensembl
RefSeq Acc Id: NM_024360   ⟹   NP_077336
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,210,632 - 84,213,045 (-)NCBI
mRatBN7.21170,705,763 - 70,708,176 (-)NCBI
Rnor_6.01174,312,837 - 74,315,249 (-)NCBI
Rnor_5.01177,360,109 - 77,362,521 (-)NCBI
RGSC_v3.41172,603,482 - 72,605,673 (-)RGD
Celera1169,677,011 - 69,679,422 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088256   ⟹   XP_038944184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81184,210,632 - 84,212,166 (-)NCBI
mRatBN7.21170,705,763 - 70,707,297 (-)NCBI
RefSeq Acc Id: NP_077336   ⟸   NM_024360
- UniProtKB: Q04666 (UniProtKB/Swiss-Prot),   A6JRV7 (UniProtKB/TrEMBL),   D4ADT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002346   ⟸   ENSRNOT00000002346
RefSeq Acc Id: XP_038944184   ⟸   XM_039088256
- Peptide Label: isoform X1
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04666-F1-model_v2 AlphaFold Q04666 1-281 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698229
Promoter ID:EPDNEW_R8754
Type:single initiation site
Name:Hes1_1
Description:hes family bHLH transcription factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01174,315,288 - 74,315,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62081 AgrOrtholog
BioCyc Gene G2FUF-20991 BioCyc
Ensembl Genes ENSRNOG00000001720 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002346 ENTREZGENE
  ENSRNOT00000002346.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  6.10.250.980 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598665 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES_HEY UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report rno:29577 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72257 IMAGE-MGC_LOAD
NCBI Gene 29577 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot
Pfam Hairy_orange UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Hes1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001720 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
Superfamily-SCOP Orange domain-like UniProtKB/Swiss-Prot
  SSF47459 UniProtKB/Swiss-Prot
TIGR TC218844
UniProt A6JRV6_RAT UniProtKB/TrEMBL
  A6JRV7 ENTREZGENE, UniProtKB/TrEMBL
  D4ADT9 ENTREZGENE, UniProtKB/TrEMBL
  F7J211_RAT UniProtKB/TrEMBL
  HES1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hes1  hes family bHLH transcription factor 1  Hes1  hairy and enhancer of split 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hes1  hairy and enhancer of split 1 (Drosophila)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference