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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hes1affects expressionISOHES1 (Homo sapiens)6480464CTDVitamin K 3 affects the expression of HES1 mRNAPMID:20044591
Hes1increases expressionISOHES1 (Homo sapiens)6480464CTDVitamin K 3 results in increased expression of HES1 proteinPMID:25005833
Hes1multiple interactionsISOHES1 (Homo sapiens)6480464CTDEUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of HES1 protein]PMID:25005833
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