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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hes1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of HES1 mRNA; Benzo(a)pyrene results in increased expression of HES1 proteinPMID:35378083
Hes1multiple interactionsEXP 6480464CTDBenzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in increased expression of HES1 mRNA]; Benzo(a)pyrene promotes the reaction [Dibutyl Phthalate results in increased expression of HES1 protein]; Dibutyl Phthalate promotes the reaction [Benzo(a)pyrene results in increased expression of HES1 mRNA]; Dibutyl Phthalate promotes the reaction [Benzo(a)pyrene results in increased expression of HES1 protein]PMID:35378083
Hes1decreases methylationISOHES1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of HES1 3' UTRPMID:27901495
Hes1increases expressionISOHES1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of HES1 mRNAPMID:20064835 PMID:20106945 PMID:21871943 PMID:22316170 PMID:26238291
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