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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hes1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of HES1 mRNAPMID:34747641
Hes1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HES1 mRNAPMID:21215274 PMID:23238561 PMID:33387578
Hes1affects expressionISOHES1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of HES1 mRNAPMID:22298810
Hes1affects expressionISOHes1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of HES1 mRNAPMID:21570461 PMID:24058054 PMID:26377647
Hes1increases expressionISOHES1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of HES1 mRNA; Tetrachlorodibenzodioxin results in increased expression of HES1 proteinPMID:14722248 PMID:16697128 PMID:20106945 PMID:21632981 PMID:26238291
Hes1increases expressionISOHes1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of HES1 mRNAPMID:19770486 PMID:21889950 PMID:23238561
Hes1multiple interactionsISOHes1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HES1 promoter]PMID:21889950
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