RGD Reference Report - Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. - Rat Genome Database

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Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif.

Authors: Grbavec, D  Stifani, S 
Citation: Grbavec D and Stifani S, Biochem Biophys Res Commun. 1996 Jun 25;223(3):701-5.
RGD ID: 8553567
Pubmed: PMID:8687460   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1996.0959   (Journal Full-text)

Groucho is a protein implicated in Notch signaling and involved in segmentation and neural development in Drosophila. Groucho forms transcription complexes with the basic helix-loop-helix proteins encoded by the hairy/Enhancer of split ("hairy-like") gene family. These interactions are mediated by the carboxyl-terminal WRPW motif of Hairy-like proteins. We are interested in determining whether Groucho and its mammalian homologues, the TLE proteins, perform conserved functions. We show that TLE1 interacts with HES-1, a murine homologue of Drosophila Hairy-like proteins, both in the yeast two-hybrid assay and in an interaction assay based on glutathione S-transferase fusion proteins. These results show that Groucho/TLE proteins and Hairy-like/HES proteins are involved in similar interactions in Drosophila and mammals and further suggest that these proteins perform conserved cellular functions.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPITLE1 (Homo sapiens)8553567 RGD 
transcription corepressor binding enablesIPIUniProtKB:Q047248553567PMID:8687460UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Hes1  (hes family bHLH transcription factor 1)


Additional Information