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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62081 Species: Rattus norvegicus RGD Object: Gene Symbol: Hes1 Name: hairy and enhancer of split 1 (Drosophila)

Acc ID: CHEBI:2981 Term: baicalin Definition: The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. CasRN: 21967-41-9 Chemical ID: MESH:C038044

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1605434	6480464	CTD	baicalin results in increased expression of HES1 mRNA	PMID:19160421
multiple interactions	ISO	RGD:1605434	6480464	CTD	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]	PMID:19160421