Abcc4 (ATP binding cassette subfamily C member 4) - Rat Genome Database

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Gene: Abcc4 (ATP binding cassette subfamily C member 4) Rattus norvegicus
Analyze
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
RGD ID: 620266
Description: Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in positive regulation of smooth muscle cell proliferation and response to tetrachloromethane. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)); PARTICIPATES IN azathioprine pharmacodynamics pathway; lamivudine pharmacokinetics pathway; mercaptopurine pharmacodynamics pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABC-tranporter; ATP-binding cassette protein C4; ATP-binding cassette subfamily C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4; LOC306166; Mrp4; multidrug resistance-associated protein 4; RGD1565953; similar to multidrug resistance-associated protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,948,387 - 102,182,912 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15101,949,433 - 102,181,375 (-)EnsemblGRCr8
mRatBN7.21595,541,186 - 95,774,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,542,315 - 95,774,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1599,449,698 - 99,683,523 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,581,669 - 100,815,501 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,510,336 - 97,744,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensemblrn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1594,392,176 - 94,624,412 (-)NCBICelera
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Cytogenetic Map15q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',7'-bis-(2-carboxyethyl)carboxyfluorescein  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenyl beta-D-glucuronide  (ISO)
4-phenylbutylamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-Hydroxymethotrexate  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
adefovir  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allocholic acid  (ISO)
allyl alcohol  (ISO)
alpha-Naphthyl-beta-D-glucuronide  (ISO)
alpha-pinene  (ISO)
amikacin  (EXP)
aminophenazone  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
angelicin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (EXP)
azathioprine  (EXP)
Azoxymethane  (ISO)
baclofen  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bosentan  (EXP)
brequinar  (ISO)
bromobenzene  (EXP)
bumetanide  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcein am  (ISO)
calciol  (ISO)
calcitriol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
cefmetazole  (ISO)
ceftazidime pentahydrate  (ISO)
celecoxib  (ISO)
cephalosporin C  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
choline  (EXP,ISO)
chrysophanol  (EXP)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
daidzein  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
emodin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ethoxyquin  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
fenofibrate  (EXP)
fipronil  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formononetin  (EXP)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (ISO)
gadolinium trichloride  (ISO)
gemfibrozil  (ISO)
gentamycin  (EXP)
Gentiopicrin  (EXP)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyburide  (ISO)
glycine betaine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
hesperetin  (ISO)
hydrochlorothiazide  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP)
indoxyl sulfate  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (EXP)
isoimperatorin  (ISO)
isoniazide  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
kanamycin A  (ISO)
kynurenic acid  (ISO)
L-methionine  (EXP,ISO)
levofloxacin  (ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
mefloquine  (ISO)
meloxicam  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
MK 571  (ISO)
N(alpha)-acetyl-L-arginine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzoylglycine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nateglinide  (ISO)
nefazodone  (ISO)
obeticholic acid  (ISO)
oltipraz  (EXP,ISO)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
Pf-06840003  (ISO)
phenobarbital  (ISO)
phenylacetic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pipemidic acid  (ISO)
piperacillin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
progesterone  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
prostaglandins E  (ISO)
psoralen  (EXP,ISO)
purines  (EXP)
quercetin  (ISO)
quercitrin  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
S-(2,4-dinitrophenyl)glutathione  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium selenide  (ISO)
stilbene oxide  (EXP)
streptozocin  (ISO)
sulbactam  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tartrazine  (ISO)
tectorigenin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
ticlopidine  (EXP)
tioguanine  (ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
topotecan  (EXP)
torasemide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
zafirlukast  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Chen C and Klaassen CD, Biochem Biophys Res Commun. 2004 Apr 23;317(1):46-53.
2. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. Denk GU, etal., J Hepatol. 2004 Apr;40(4):585-91.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
5. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
6. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
7. Induction of drug metabolism enzymes and transporters by oltipraz in rats. Merrell MD, etal., J Biochem Mol Toxicol. 2008;22(2):128-35.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Okumura H, etal., Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
17. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. Sassi Y, etal., J Clin Invest. 2008 Aug;118(8):2747-57.
18. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. van Aubel RA, etal., J Am Soc Nephrol 2002 Mar;13(3):595-603.
19. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:12883481   PMID:15297306   PMID:15504935   PMID:19671067   PMID:19946888   PMID:21167233   PMID:21237168   PMID:23306951   PMID:24130369   PMID:25173977   PMID:25986174   PMID:26244301  
PMID:26458556   PMID:28298215   PMID:30995593   PMID:33132311   PMID:35269592  


Genomics

Comparative Map Data
Abcc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,948,387 - 102,182,912 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15101,949,433 - 102,181,375 (-)EnsemblGRCr8
mRatBN7.21595,541,186 - 95,774,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,542,315 - 95,774,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1599,449,698 - 99,683,523 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,581,669 - 100,815,501 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,510,336 - 97,744,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensemblrn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1594,392,176 - 94,624,412 (-)NCBICelera
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Cytogenetic Map15q24NCBI
ABCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381395,019,835 - 95,301,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1395,019,835 - 95,301,822 (-)Ensemblhg38GRCh38
GRCh371395,672,089 - 95,953,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361394,470,084 - 94,751,688 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341394,470,089 - 94,751,684NCBI
Celera1376,520,037 - 76,801,492 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1376,269,792 - 76,551,747 (-)NCBIHuRef
CHM1_11395,641,739 - 95,923,875 (-)NCBICHM1_1
T2T-CHM13v2.01394,223,430 - 94,506,029 (-)NCBIT2T-CHM13v2.0
Abcc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,720,104 - 118,945,475 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,720,104 - 118,943,631 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3814118,482,692 - 118,707,856 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,482,692 - 118,706,219 (-)Ensemblmm10GRCm38
MGSCv3714118,881,914 - 119,105,441 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614117,366,402 - 117,589,897 (-)NCBIMGSCv36mm8
Celera14117,040,185 - 117,267,837 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1462.24NCBI
Abcc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540414,700,808 - 14,928,617 (+)Ensembl
ChiLan1.0NW_00495540414,700,808 - 14,927,944 (+)NCBIChiLan1.0ChiLan1.0
ABCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21496,549,596 - 96,832,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11395,218,532 - 95,500,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01376,193,929 - 76,476,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11395,349,915 - 95,596,193 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1395,349,915 - 95,582,058 (-)EnsemblpanPan2panpan1.1
ABCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,767,033 - 46,013,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,765,835 - 46,013,505 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2245,552,541 - 45,797,861 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02246,197,405 - 46,443,625 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2246,196,166 - 46,443,705 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12245,859,950 - 46,105,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02245,893,451 - 46,139,289 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02245,899,895 - 46,145,744 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945181,327,558 - 181,555,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,648 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100738425
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11164,861,069 - 64,996,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21171,819,382 - 71,859,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,821,887 - 74,106,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl373,821,134 - 74,106,579 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604630,211,012 - 30,527,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248791,811,651 - 2,060,099 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248791,811,686 - 2,060,221 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1127,216,829 - 7,449,634 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:484
Count of miRNA genes:153
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000013366, ENSRNOT00000031036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1588677086104695021Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1588677086104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1595260808102247606Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat

Markers in Region
RH143776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,709,760 - 95,709,909 (+)MAPPERmRatBN7.2
Rnor_6.015103,863,409 - 103,863,557NCBIRnor6.0
Rnor_5.015107,293,048 - 107,293,196UniSTSRnor5.0
RGSC_v3.415103,546,131 - 103,546,279UniSTSRGSC3.4
Celera1594,559,460 - 94,559,608UniSTS
RH 3.4 Map15651.3UniSTS
Cytogenetic Map15q24UniSTS
BI286235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,775,474 - 95,775,679 (+)MAPPERmRatBN7.2
Rnor_6.015103,928,620 - 103,928,824NCBIRnor6.0
Rnor_5.015107,358,025 - 107,358,229UniSTSRnor5.0
RGSC_v3.415103,612,519 - 103,612,723UniSTSRGSC3.4
Celera1594,625,559 - 94,625,763UniSTS
RH 3.4 Map15650.3UniSTS
Cytogenetic Map15q24UniSTS
AU047861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,740,080 - 95,740,374 (+)MAPPERmRatBN7.2
Rnor_6.015103,893,726 - 103,894,017NCBIRnor6.0
Rnor_5.015107,323,365 - 107,323,656UniSTSRnor5.0
RGSC_v3.415103,576,447 - 103,576,738UniSTSRGSC3.4
Celera1594,589,955 - 94,590,246UniSTS
Cytogenetic Map15q24UniSTS
RH141533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,542,403 - 95,542,613 (+)MAPPERmRatBN7.2
Rnor_6.015103,696,633 - 103,696,842NCBIRnor6.0
Rnor_5.015107,127,515 - 107,127,724UniSTSRnor5.0
RGSC_v3.415103,384,955 - 103,385,164UniSTSRGSC3.4
Celera1594,392,283 - 94,392,492UniSTS
RH 3.4 Map15648.7UniSTS
Cytogenetic Map15q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013366   ⟹   ENSRNOP00000013366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,181,364 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,774,272 (-)Ensembl
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000031036   ⟹   ENSRNOP00000033826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,181,364 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,774,272 (-)Ensembl
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100006   ⟹   ENSRNOP00000076836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
mRatBN7.2 Ensembl1595,542,799 - 95,774,283 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109236   ⟹   ENSRNOP00000076917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
mRatBN7.2 Ensembl1595,542,799 - 95,774,283 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117189   ⟹   ENSRNOP00000089564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,128,294 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,721,172 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128450   ⟹   ENSRNOP00000104561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
RefSeq Acc Id: NM_133411   ⟹   NP_596902
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,949,415 - 102,181,364 (-)NCBI
mRatBN7.21595,542,297 - 95,774,272 (-)NCBI
Rnor_6.015103,696,526 - 103,927,592 (-)NCBI
Rnor_5.015107,127,408 - 107,356,997 (-)NCBI
RGSC_v3.415103,384,848 - 103,611,238 (-)RGD
Celera1594,392,176 - 94,624,412 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092966   ⟹   XP_038948894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,182,912 (-)NCBI
mRatBN7.21595,541,186 - 95,774,898 (-)NCBI
RefSeq Acc Id: XM_039092967   ⟹   XP_038948895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,182,912 (-)NCBI
mRatBN7.21595,541,186 - 95,774,898 (-)NCBI
RefSeq Acc Id: XM_063273922   ⟹   XP_063129992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,128,722 (-)NCBI
RefSeq Acc Id: XM_063273923   ⟹   XP_063129993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,990,866 - 102,182,912 (-)NCBI
RefSeq Acc Id: XM_063273924   ⟹   XP_063129994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815102,056,959 - 102,182,912 (-)NCBI
RefSeq Acc Id: XM_063273925   ⟹   XP_063129995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,075,178 (-)NCBI
RefSeq Acc Id: NP_596902   ⟸   NM_133411
- UniProtKB: F1M3J4 (UniProtKB/Swiss-Prot),   Q6QMG6 (UniProtKB/TrEMBL),   Q59DL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033826   ⟸   ENSRNOT00000031036
Ensembl Acc Id: ENSRNOP00000013366   ⟸   ENSRNOT00000013366
RefSeq Acc Id: XP_038948895   ⟸   XM_039092967
- Peptide Label: isoform X2
- UniProtKB: Q6QMG6 (UniProtKB/Swiss-Prot),   F1M3J4 (UniProtKB/Swiss-Prot),   Q59DL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948894   ⟸   XM_039092966
- Peptide Label: isoform X1
- UniProtKB: Q6QMG6 (UniProtKB/Swiss-Prot),   F1M3J4 (UniProtKB/Swiss-Prot),   A0A8I5YBX7 (UniProtKB/TrEMBL),   Q59DL1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089564   ⟸   ENSRNOT00000117189
Ensembl Acc Id: ENSRNOP00000076836   ⟸   ENSRNOT00000100006
Ensembl Acc Id: ENSRNOP00000076917   ⟸   ENSRNOT00000109236
RefSeq Acc Id: XP_063129992   ⟸   XM_063273922
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A923 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129995   ⟸   XM_063273925
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063129993   ⟸   XM_063273923
- Peptide Label: isoform X4
- UniProtKB: A6HUG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129994   ⟸   XM_063273924
- Peptide Label: isoform X5
- UniProtKB: A6HUG6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000104561   ⟸   ENSRNOT00000128450
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3J4-F1-model_v2 AlphaFold F1M3J4 1-1325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620266 AgrOrtholog
BioCyc Gene G2FUF-12442 BioCyc
Ensembl Genes ENSRNOG00000010064 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031036 ENTREZGENE
  ENSRNOT00000100006 ENTREZGENE
  ENSRNOT00000117189 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCC4 UniProtKB/Swiss-Prot
  ABCC4_TMD2 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:170924 UniProtKB/Swiss-Prot
NCBI Gene 170924 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  PTHR24223:SF357 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCC4 RGD
PhenoGen Abcc4 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010064 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0H3_RAT UniProtKB/TrEMBL
  A0A8I5YBX7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A923 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKX0_RAT UniProtKB/TrEMBL
  A0ABK0LI83_RAT UniProtKB/TrEMBL
  A6HUG6 ENTREZGENE, UniProtKB/TrEMBL
  F1LR52_RAT UniProtKB/TrEMBL
  F1M3J4 ENTREZGENE, UniProtKB/Swiss-Prot
  Q59DL1 ENTREZGENE, UniProtKB/TrEMBL
  Q6QMG5_RAT UniProtKB/TrEMBL
  Q6QMG6 ENTREZGENE
UniProt Secondary Q6QMG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcc4  ATP binding cassette subfamily C member 4  Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  RGD1565953  similar to multidrug resistance-associated protein 4  Data merged from RGD:1565953 737654 PROVISIONAL
2010-11-16 Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565953  similar to multidrug resistance-associated protein 4   RGD1565953_predicted  similar to multidrug resistance-associated protein 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565953_predicted  similar to multidrug resistance-associated protein 4 (predicted)  LOC306166  similar to multidrug resistance-associated protein 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306166  similar to multidrug resistance-associated protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney