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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:5778
Term: hydrochlorothiazide
Definition: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:D006852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4increases exportISOAbcc4 (Mus musculus)6480464CTDABCC4 protein results in increased export of HydrochlorothiazidePMID:17135398
Abcc4increases transportISOABCC4 (Homo sapiens)6480464CTDABCC4 protein results in increased transport of HydrochlorothiazidePMID:17939016
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