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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:6619
Term: MK 571
Definition: A quinoline that has formula C26H27ClN2O3S2.
Chemical ID: MESH:C059141
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4decreases activityISOABCC4 (Homo sapiens)6480464CTDverlukast results in decreased activity of ABCC4 proteinPMID:16004972
Abcc4multiple interactionsISOABCC4 (Homo sapiens)6480464CTDverlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; verlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]; verlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]PMID:16004972 PMID:16156793
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