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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of ABCC4 mRNAPMID:32437819
Abcc4increases expressionEXP 6480464CTDValproic Acid results in increased expression of ABCC4 mRNAPMID:27765674
Abcc4decreases expressionISOABCC4 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of ABCC4 mRNAPMID:28001369
Abcc4increases expressionISOABCC4 (Homo sapiens)6480464CTDValproic Acid results in increased expression of ABCC4 mRNAPMID:23179753 PMID:26272509 PMID:28001369
Abcc4multiple interactionsISOABCC4 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCC4 mRNA; Valproic Acid inhibits the reaction [Colforsin results in decreased expression of ABCC4 mRNA]PMID:27188386 PMID:37385477
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