Abcc4 (ATP binding cassette subfamily C member 4 (PEL blood group)) - Rat Genome Database

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Gene: Abcc4 (ATP binding cassette subfamily C member 4 (PEL blood group)) Ictidomys tridecemlineatus
Analyze
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4 (PEL blood group) (Ensembl:ATP binding cassette subfamily C member 4)
RGD ID: 12692846
Description: ENCODES a protein that exhibits ABC-type bile acid transporter activity (inferred); ABC-type glutathione S-conjugate transporter activity (inferred); ABC-type transporter activity (inferred); INVOLVED IN bile acid signaling pathway (ortholog); cilium assembly (ortholog); positive regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN azathioprine pharmacodynamics pathway; bile acid signaling pathway; lamivudine pharmacokinetics pathway; ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); cholestasis (ortholog); cognitive disorder (ortholog); FOUND IN basolateral plasma membrane (ortholog); cilium (ortholog); external side of apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP binding cassette subfamily C member 4; ATP binding cassette subfamily C member 4, transcript variant X1; ATP binding cassette subfamily C member 4, transcript variant X2; multidrug resistance-associated protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945181,327,558 - 181,555,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Abcc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945181,327,558 - 181,555,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381395,019,835 - 95,301,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1395,019,835 - 95,301,475 (-)EnsemblGRCh38hg38GRCh38
GRCh371395,672,089 - 95,953,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361394,470,084 - 94,751,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 341394,470,089 - 94,751,684NCBI
Celera1376,520,037 - 76,801,492 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1376,269,792 - 76,551,747 (-)NCBIHuRef
CHM1_11395,641,739 - 95,923,875 (-)NCBICHM1_1
T2T-CHM13v2.01394,223,430 - 94,506,029 (-)NCBIT2T-CHM13v2.0
Abcc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,720,104 - 118,945,475 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,720,104 - 118,943,631 (-)EnsemblGRCm39 Ensembl
GRCm3814118,482,692 - 118,707,856 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,482,692 - 118,706,219 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714118,881,914 - 119,105,441 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614117,366,402 - 117,589,897 (-)NCBIMGSCv36mm8
Celera14117,040,185 - 117,267,837 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1462.24NCBI
Abcc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,948,387 - 102,182,912 (-)NCBIGRCr8
mRatBN7.21595,541,186 - 95,774,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,542,315 - 95,774,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1599,449,698 - 99,683,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,581,669 - 100,815,501 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,510,336 - 97,744,179 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Celera1594,392,176 - 94,624,412 (-)NCBICelera
Cytogenetic Map15q24NCBI
Abcc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540414,700,808 - 14,928,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540414,700,808 - 14,927,944 (+)NCBIChiLan1.0ChiLan1.0
ABCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21496,549,596 - 96,832,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11395,218,532 - 95,500,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01376,193,929 - 76,476,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11395,349,915 - 95,596,193 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1395,349,915 - 95,582,058 (-)Ensemblpanpan1.1panPan2
ABCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,767,033 - 46,013,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,765,835 - 46,013,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,552,541 - 45,797,861 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02246,197,405 - 46,443,625 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2246,196,166 - 46,443,705 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12245,859,950 - 46,105,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02245,893,451 - 46,139,289 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02245,899,895 - 46,145,744 (-)NCBIUU_Cfam_GSD_1.0
LOC100738425
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11164,861,069 - 64,996,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21171,819,382 - 71,859,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,821,887 - 74,106,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl373,821,134 - 74,106,579 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604630,211,012 - 30,527,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248791,811,651 - 2,060,099 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248791,811,686 - 2,060,221 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000003752   ⟹   ENSSTOP00000003361
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,648 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000032800   ⟹   ENSSTOP00000031937
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,597 (+)Ensembl
RefSeq Acc Id: XM_005317040   ⟹   XP_005317097
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945181,327,558 - 181,555,006 (-)NCBI
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005317042   ⟹   XP_005317099
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945181,327,558 - 181,555,005 (-)NCBI
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317097 (Get FASTA)   NCBI Sequence Viewer  
  XP_005317099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000003361.3
  ENSSTOP00000031937.1
GenBank Protein KAG3293277 (Get FASTA)   NCBI Sequence Viewer  
  KAG3293278 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005317097   ⟸   XM_005317040
- Peptide Label: isoform X1
- UniProtKB: I3M2W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005317099   ⟸   XM_005317042
- Peptide Label: isoform X2
- UniProtKB: A0A287DEG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000031937   ⟸   ENSSTOT00000032800
RefSeq Acc Id: ENSSTOP00000003361   ⟸   ENSSTOT00000003752
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003738 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003752.3 UniProtKB/TrEMBL
  ENSSTOT00000032800.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCC4 UniProtKB/TrEMBL
  ABCC4_TMD2 UniProtKB/TrEMBL
  CFTR/ABCC7 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Abcc4 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/TrEMBL
  PTHR24223:SF357 UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PRINTS CYSFIBREGLTR UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF90123 UniProtKB/TrEMBL
UniProt A0A287DEG2 ENTREZGENE, UniProtKB/TrEMBL
  I3M2W6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-07 Abcc4  ATP binding cassette subfamily C member 4 (PEL blood group)  Abcc4  ATP binding cassette subfamily C member 4  Symbol and/or name change 5135510 APPROVED