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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:34562
Term: Benzo[a]pyrene-7,8-diol
Definition: A pyrene that has formula C20H14O2.
Chemical ID: MESH:C017228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4increases exportISOABCC4 (Homo sapiens)6480464CTDABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiolPMID:22155354
Abcc4increases expressionISOABCC4 (Homo sapiens)6480464CTDbenzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 mRNA; benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 proteinPMID:22155354
Abcc4multiple interactionsISOABCC4 (Homo sapiens)6480464CTD[ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol] which results in decreased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNAPMID:22155354
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