GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc4 | affects response to substance | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | ABCC4 gene SNP affects the susceptibility to Methotrexate | PMID:23222202 | Abcc4 | decreases expression | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | Methotrexate results in decreased expression of ABCC4 mRNA | PMID:23897011 | Abcc4 | decreases response to substance | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | ABCC4 protein results in decreased susceptibility to Methotrexate | PMID:17003774 | Abcc4 | increases export | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | ABCC4 protein results in increased export of Methotrexate | PMID:21483698 | Abcc4 | increases transport | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | ABCC4 protein results in increased transport of Methotrexate | PMID:11856762 | Abcc4 | multiple interactions | ISO | ABCC4 (Homo sapiens) | 6480464 | CTD | 2,4-dinitrophenyl-S-(N-acetylcysteine) inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]; 4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]; hippuric acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]; Indican inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]; indoleacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]; Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]; naphthyl glucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]; phenylacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]; S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]; Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate] | PMID:11856762 PMID:15454390 PMID:21483698 | | ||||||||||||||||||||||
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