Slc2a1 (solute carrier family 2 member 1) - Rat Genome Database

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Gene: Slc2a1 (solute carrier family 2 member 1) Rattus norvegicus
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Symbol: Slc2a1
Name: solute carrier family 2 member 1
RGD ID: 3704
Description: Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; Glut1 deficiency syndrome pathway; hypoxia inducible factor pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glucose transporter type 1, erythrocyte/brain; GLUT-1; Glut1; GLUTB; GTG1; Gtg3; RATGTG1; solute carrier family 2 (facilitated glucose transporter) member 1; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1; solute carrier family 2,member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp103  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,002,522 - 138,030,742 (+)NCBIGRCr8
mRatBN7.25132,717,196 - 132,745,416 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,447,151 - 135,475,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,203,611 - 137,231,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,224,210 - 137,252,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
RH 3.4 Map5865.0RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
Ataxia  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease dominant intermediate C  (ISO)
childhood absence epilepsy  (ISO)
chromosome 17q23.1-q23.2 deletion syndrome  (ISO)
Colonic Neoplasms  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
dystonia  (ISO)
dystonia 9  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (IEP)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
glomerulosclerosis  (ISO)
glucose transporter type 1 deficiency syndrome  (ISO)
glucose transporter type 1 deficiency syndrome 1  (ISO,ISS)
glucose transporter type 1 deficiency syndrome 2  (ISO)
hemangioma  (ISO)
hepatocellular carcinoma  (ISO)
Hirschsprung's disease  (ISO)
hypertension  (IEP)
hypothyroidism  (IEP)
idiopathic generalized epilepsy 12  (ISO)
Infantile Capillary Hemangioma  (ISO)
inherited metabolic disorder  (ISO)
intellectual disability  (ISO)
junctional epidermolysis bullosa Herlitz type  (ISO)
Liver Neoplasms  (ISO)
malignant mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (IEP)
migraine  (ISO)
Muscle Weakness  (ISO)
Myalgia  (ISO)
myelomeningocele  (ISO)
Myocardial Reperfusion Injury  (IEP)
Myoclonic Epilepsies  (ISO)
myopathy  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
nervous system disease  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Peritoneal Neoplasms  (ISO)
pre-eclampsia  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Stomatin-Deficient Cryohydrocytosis with Mental Retardation, Seizures, Cataracts, and Massive Hepatosplenomegaly  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dinitrophenol  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-deoxy-2-((18)F)fluoro-D-glucose  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxy-17beta-estradiol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-O-methyl-D-glucose  (ISO)
3-Phenyl-1-propanol  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
7-hydroxyflavone  (ISO)
acadesine  (ISO)
acarbose  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-naphthoflavone  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthracene-1,8,9-triol  (ISO)
antirheumatic drug  (ISO)
Apaziquone  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azide  (EXP)
barbiturates  (ISO)
beauvericin  (ISO)
benzaldehyde  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bruceine D  (ISO)
bucladesine  (ISO)
bupivacaine  (ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
chloral hydrate  (ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
corosolic acid  (ISO)
corticosterone  (EXP,ISO)
crotonaldehyde  (ISO)
cumene  (ISO)
curcumin  (ISO)
Cyclofenil  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
dacarbazine  (ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
Deoxycorticosterone acetate  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Dihydrotanshinone I  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enniatin  (ISO)
epoxiconazole  (ISO)
escitalopram  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
eupatilin  (ISO)
fenbendazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
Fusaric acid  (ISO)
Genipin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gentamycin C  (ISO)
glucose  (EXP,ISO)
glycidyl methacrylate  (ISO)
glycine  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hispidulin  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
ibuprofen  (ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferide  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-dehydroascorbic acid  (EXP,ISO)
L-mimosine  (EXP,ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mebendazole  (ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylene blue  (ISO)
methylmercury chloride  (EXP,ISO)
Mezerein  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
Niflumic acid  (ISO)
nimesulide  (ISO)
nobiletin  (ISO)
Nonidet P-40  (ISO)
ochratoxin A  (ISO)
ofloxacin  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
organoselenium compound  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
promethazine  (EXP)
propanal  (ISO)
propofol  (ISO)
prostaglandin E2  (ISO)
protoporphyrin  (ISO)
puerarin  (EXP)
Pyridostigmine bromide  (ISO)
pyrithiamine  (EXP)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
roxadustat  (ISO)
saccharin  (ISO)
sarpogrelate  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
sinensetin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tadalafil  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraethylenepentamine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (ISO)
tolbutamide  (ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Association of HaeIII single nucleotide polymorphisms in the SLC2A1 gene with risk of diabetic nephropathy; evidence from Kurdish patients with type 2 diabetes mellitus. Amini S, etal., QJM. 2016 Jun;109(6):399-404. doi: 10.1093/qjmed/hcv149. Epub 2015 Sep 3.
2. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
3. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). Barnes K, etal., J Cell Sci 2002 Jun 1;115(Pt 11):2433-42.
4. Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage. Baroni MG, etal., Hum Genet. 1994 Jun;93(6):675-80.
5. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Birnbaum MJ, etal., Proc Natl Acad Sci U S A 1986 Aug;83(16):5784-8.
6. Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. Boado RJ and Pardridge WM, J Neurochem 2002 Feb;80(3):552-4.
7. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
8. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
9. A 10 bp deletion polymorphism and 2 new variations in the GLUT1 gene associated with meningomyelocele. Cormier CM, etal., Reprod Sci. 2011 May;18(5):463-8. doi: 10.1177/1933719110388293. Epub 2010 Dec 6.
10. Immunolocalization of GLUT-1 glucose transporter in rat skeletal muscle and in normal and hypoxic cardiac tissue. Doria-Medina CL, etal., Am J Physiol. 1993 Sep;265(3 Pt 1):E454-64.
11. Diabetes alters the expression and activity of the human placental GLUT1 glucose transporter. Gaither K, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):695-701.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries. Gaudreault N, etal., Endothelium. 2006 Sep-Oct;13(5):317-24.
14. Effects of chronic undernutrition on glucose uptake and glucose transporter proteins in rat heart. Gavete ML, etal., Endocrinology 2002 Nov;143(11):4295-303.
15. GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury? Gnudi L, etal., Hypertension. 2003 Jul;42(1):19-24. Epub 2003 May 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Gong X, etal., Invest Ophthalmol Vis Sci. 2001 Mar;42(3):539-48.
18. GLUT1 gene polymorphism in non-insulin-dependent diabetes mellitus: genetic susceptibility relationship with cardiovascular risk factors and microangiopathic complications in a Mediterranean population. Gutierrez C, etal., Diabetes Res Clin Pract. 1998 Aug;41(2):113-20.
19. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
20. SLC2A1 gene analysis of Japanese patients with glucose transporter 1 deficiency syndrome. Hashimoto N, etal., J Hum Genet. 2011 Dec;56(12):846-51. doi: 10.1038/jhg.2011.115. Epub 2011 Oct 20.
21. A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. Hodgkinson AD, etal., J Diabetes Complications. 2005 Mar-Apr;19(2):65-9.
22. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. Holman GD, etal., J Biol Chem. 1990 Oct 25;265(30):18172-9.
23. Influence of blood glucose on the expression of glucose trans-porter proteins 1 and 3 in the brain of diabetic rats. Hou WK, etal., Chin Med J (Engl). 2007 Oct 5;120(19):1704-9.
24. Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Hrelia S, etal., Biochim Biophys Acta 2002 Dec 23;1567(1):150-6.
25. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Hussar P, etal., Chem Senses 2002 Jan;27(1):7-11.
26. Stimulation of GLUT-1 glucose transporter expression in response to hyperosmolarity. Hwang DY and Ismail-Beigi F, Am J Physiol Cell Physiol. 2001 Oct;281(4):C1365-72.
27. Selective demonstration of mural nerves in ganglionic and aganglionic colon by immunohistochemistry for glucose transporter-1: prominent extrinsic nerve pattern staining in Hirschsprung disease. Kakita Y, etal., Arch Pathol Lab Med. 2000 Sep;124(9):1314-9.
28. Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat. Korgun ET, etal., Folia Histochem Cytobiol. 2011;49(2):325-34.
29. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
30. IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. Lane RH, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1450-60.
31. Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. Lane RH, etal., Am J Physiol. 1999 Jan;276(1 Pt 1):E135-42.
32. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Langdown ML and Sugden MC, Mol Cell Endocrinol 2001 Dec 20;185(1-2):109-17.
33. The role of SLC2A1 mutations in myoclonic astatic epilepsy and absence epilepsy, and the estimated frequency of GLUT1 deficiency syndrome. Larsen J, etal., Epilepsia. 2015 Dec;56(12):e203-8. doi: 10.1111/epi.13222. Epub 2015 Nov 5.
34. Uncovering microdeletions in patients with severe Glut-1 deficiency syndrome using SNP oligonucleotide microarray analysis. Levy B, etal., Mol Genet Metab. 2010 Jun;100(2):129-35. doi: 10.1016/j.ymgme.2010.03.007. Epub 2010 Mar 17.
35. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Liou ST and Wang C, Arch Biochem Biophys. 2005 Mar 15;435(2):253-63.
36. Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Liu Z, etal., Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. Epub 2006 Oct 17.
37. Insulin therapy normalizes GLUT1 glucose transporter mRNA but not immunoreactive transporter protein in streptozocin-diabetic rats. Lutz AJ and Pardridge WM, Metabolism. 1993 Aug;42(8):939-44.
38. Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland. Macheda ML, etal., Cell Tissue Res 2003 Jan;311(1):91-7. Epub 2002 Nov 15.
39. Immunolocalization of GLUT1 and GLUT3 glucose transporters in primary cultured neurons and glia. Maher F J Neurosci Res. 1995 Nov 1;42(4):459-69.
40. Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population. Makni K, etal., Diabetes Metab Res Rev. 2008 Oct;24(7):544-8.
41. Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype. Marin-Valencia I, etal., Neurobiol Dis. 2012 Oct;48(1):92-101. doi: 10.1016/j.nbd.2012.04.011. Epub 2012 Apr 23.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. Muralimanoharan S, etal., Placenta. 2012 Oct;33(10):816-23. doi: 10.1016/j.placenta.2012.07.002. Epub 2012 Jul 26.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Nedvedova I, etal., Physiol Genomics. 2018 Jul 1;50(7):532-541. doi: 10.1152/physiolgenomics.00040.2017. Epub 2018 Apr 20.
46. Co-localization of GLUT1 and GLUT4 in the blood-brain barrier of the rat ventromedial hypothalamus. Ngarmukos C, etal., Brain Res. 2001 May 4;900(1):1-8. doi: 10.1016/s0006-8993(01)02184-9.
47. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. North PE, etal., Hum Pathol. 2000 Jan;31(1):11-22.
48. Involvement of nuclear transcription factor Sp1 in regulating glucose transporter-1 gene expression during rat trophoblast differentiation. Okamoto Y, etal., Biochem Biophys Res Commun 2001 Nov 9;288(4):940-8.
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory. Pearson-Leary J and McNay EC, J Neurosci. 2016 Nov 23;36(47):11851-11864. doi: 10.1523/JNEUROSCI.1700-16.2016.
51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
53. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
54. Immunohistochemical expression of GLUT1 and its correlation with unfavorable histology and TP53 codon 72 polymorphism in Wilms tumors. Rakheja D, etal., Pediatr Dev Pathol. 2012 Jul-Aug;15(4):286-92. doi: 10.2350/12-01-1151-OA.1. Epub 2012 Apr 6.
55. Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells. Rauch MC, etal., J Cell Physiol. 2006 May;207(2):397-406.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Ritterhoff J, etal., Circ Res. 2020 Jan 17;126(2):182-196. doi: 10.1161/CIRCRESAHA.119.315483. Epub 2019 Nov 11.
60. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
61. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. Rumsey SC, etal., J Biol Chem. 1997 Jul 25;272(30):18982-9.
62. T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates. Santalucía T, etal., Mol Cell Endocrinol. 2006 Jun 7;251(1-2):9-16. Epub 2006 Apr 3.
63. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Scheepers A, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):364-71.
64. GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Seidner G, etal., Nat Genet. 1998 Feb;18(2):188-91.
65. Effects of 17beta-estradiol on glucose transporter 1 expression and endothelial cell survival following focal ischemia in the rats. Shi J, etal., Exp Brain Res. 1997 Nov;117(2):200-6.
66. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Simpson IA, etal., Ann Neurol. 1994 May;35(5):546-51.
67. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
68. Family-based association study between SLC2A1, HK1, and LEPR polymorphisms with myelomeningocele in Chile. Suazo J, etal., Reprod Sci. 2013 Oct;20(10):1207-14. doi: 10.1177/1933719113477489. Epub 2013 Feb 20.
69. Phosphodiesterase inhibitor improves renal tubulointerstitial hypoxia of the diabetic rat kidney. Sun HK, etal., Korean J Intern Med. 2012 Jun;27(2):163-70. doi: 10.3904/kjim.2012.27.2.163. Epub 2012 May 31.
70. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
71. Effect of transient ischemia on the expression of glucose transporters GLUT-1 and GLUT-4 in rat myocardium. Tardy-Cantalupi I, etal., J Mol Cell Cardiol. 1999 May;31(5):1143-55.
72. Lifestyle intervention up-regulates gene and protein levels of molecules involved in insulin signaling in the endometrium of overweight/obese women with polycystic ovary syndrome. Ujvari D, etal., Hum Reprod. 2014 Jul;29(7):1526-35. Epub 2014 May 19.
73. Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF. Wang Y, etal., Lab Invest. 2010 Jan;90(1):83-97. doi: 10.1038/labinvest.2009.95. Epub 2009 Nov 16.
74. Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect. Weber YG, etal., Neurology. 2011 Sep 6;77(10):959-64. doi: 10.1212/WNL.0b013e31822e0479. Epub 2011 Aug 10.
75. [The expression and role of glucose transporter-1 in infantile hemangioma]. Yuan SM, etal., Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Mar;23(2):90-3.
76. Association of stomatin (band 7.2b) with Glut1 glucose transporter. Zhang JZ, etal., Arch Biochem Biophys. 1999 Dec 1;372(1):173-8.
77. Dynamic expression of glucose transporters 1 and 3 in the brain of diabetic rats with cerebral ischemia reperfusion. Zhang WW, etal., Chin Med J (Engl). 2009 Sep 5;122(17):1996-2001.
Additional References at PubMed
PMID:1429721   PMID:1714544   PMID:3198639   PMID:7589840   PMID:7593639   PMID:8457197   PMID:9751501   PMID:10198040   PMID:10227690   PMID:10394363   PMID:10862609   PMID:11172003  
PMID:11259273   PMID:11681785   PMID:12002265   PMID:12506324   PMID:12531786   PMID:14519432   PMID:14729246   PMID:14741039   PMID:15166316   PMID:15359219   PMID:15489334   PMID:15808844  
PMID:15811071   PMID:15855808   PMID:15975910   PMID:16091581   PMID:16140905   PMID:16162661   PMID:16449286   PMID:16461188   PMID:17189352   PMID:17369047   PMID:17369472   PMID:17878754  
PMID:18196278   PMID:18245775   PMID:18347014   PMID:18474279   PMID:18511518   PMID:18650261   PMID:18787834   PMID:18797165   PMID:18802725   PMID:18957618   PMID:19546347   PMID:19681047  
PMID:19841136   PMID:19950593   PMID:20375116   PMID:20458337   PMID:21069159   PMID:21141602   PMID:21562080   PMID:21605500   PMID:21613414   PMID:21624469   PMID:21773965   PMID:21791420  
PMID:22125125   PMID:22258767   PMID:22433294   PMID:22516433   PMID:22579067   PMID:22871113   PMID:23265586   PMID:23280796   PMID:23680377   PMID:23975336   PMID:24062089   PMID:24329691  
PMID:24382486   PMID:24610532   PMID:24726496   PMID:24739976   PMID:25101238   PMID:25982116   PMID:26347179   PMID:26590355   PMID:26953753   PMID:27078104   PMID:28495754   PMID:28993322  
PMID:29476059   PMID:29490264   PMID:30335140   PMID:30837370   PMID:31162576   PMID:31765739   PMID:32445055   PMID:33856052   PMID:35038771   PMID:35084654   PMID:35380292   PMID:35713797  
PMID:36291063   PMID:36521282   PMID:36963496   PMID:37879153  


Genomics

Comparative Map Data
Slc2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,002,522 - 138,030,742 (+)NCBIGRCr8
mRatBN7.25132,717,196 - 132,745,416 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,447,151 - 135,475,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,203,611 - 137,231,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,224,210 - 137,252,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
RH 3.4 Map5865.0RGD
Cytogenetic Map5q36NCBI
SLC2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,925,353 - 42,958,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,925,353 - 42,958,893 (-)EnsemblGRCh38hg38GRCh38
GRCh37143,391,024 - 43,424,539 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,164,102 - 43,197,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 34143,060,611 - 43,093,594NCBI
Celera141,673,133 - 41,706,939 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,511,000 - 41,544,561 (-)NCBIHuRef
CHM1_1143,507,796 - 43,541,586 (-)NCBICHM1_1
T2T-CHM13v2.0142,795,821 - 42,829,338 (-)NCBIT2T-CHM13v2.0
Slc2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,966,001 - 118,994,527 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,965,908 - 118,995,180 (+)EnsemblGRCm39 Ensembl
GRCm384119,108,745 - 119,137,330 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,108,711 - 119,137,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv374118,781,350 - 118,809,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,606,700 - 118,635,259 (+)NCBIMGSCv36mm8
Celera4117,836,249 - 117,864,839 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
Slc2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,408,042 - 2,439,511 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,408,042 - 2,438,788 (-)NCBIChiLan1.0ChiLan1.0
SLC2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,853,979 - 183,886,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,995,645 - 183,028,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,224,273 - 42,257,184 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,600,733 - 43,634,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,600,733 - 43,634,143 (-)Ensemblpanpan1.1panPan2
SLC2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115463,307 - 493,145 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15463,237 - 493,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15719,928 - 748,675 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015546,520 - 575,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15546,386 - 575,265 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115456,107 - 484,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015515,411 - 544,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015532,601 - 561,334 (+)NCBIUU_Cfam_GSD_1.0
Slc2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,381,102 - 58,411,854 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,206,644 - 24,236,713 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,205,878 - 24,236,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,974,567 - 90,007,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,002,030 - 90,008,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,904,125 - 26,937,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,117,561 - 2,148,037 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,110,310 - 2,148,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a1
202 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:456
Count of miRNA genes:236
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000064452
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
D5Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,743,341 - 132,743,469 (+)MAPPERmRatBN7.2
Rnor_6.05138,180,823 - 138,180,950NCBIRnor6.0
Rnor_5.05141,990,560 - 141,990,687UniSTSRnor5.0
RGSC_v3.45139,716,946 - 139,717,074RGDRGSC3.4
RGSC_v3.45139,716,947 - 139,717,074UniSTSRGSC3.4
RGSC_v3.15139,722,172 - 139,722,300RGD
Celera5131,269,936 - 131,270,074UniSTS
RH 3.4 Map5868.7UniSTS
RH 3.4 Map5868.7RGD
RH 2.0 Map5861.1RGD
Cytogenetic Map5q36.1UniSTS
D5Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,744,136 - 132,744,368 (+)MAPPERmRatBN7.2
Rnor_6.05138,181,618 - 138,181,849NCBIRnor6.0
Rnor_5.05141,991,355 - 141,991,586UniSTSRnor5.0
RGSC_v3.45139,717,741 - 139,717,973RGDRGSC3.4
RGSC_v3.45139,717,742 - 139,717,973UniSTSRGSC3.4
RGSC_v3.15139,722,967 - 139,723,199RGD
Celera5131,270,742 - 131,270,973UniSTS
RH 3.4 Map5867.2RGD
RH 3.4 Map5867.2UniSTS
RH 2.0 Map5860.2RGD
SHRSP x BN Map570.6499RGD
Cytogenetic Map5q36.1UniSTS
Cytogenetic Map5q36UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,744,921 - 132,745,113 (+)MAPPERmRatBN7.2
Rnor_6.05138,182,403 - 138,182,594NCBIRnor6.0
Rnor_5.05141,992,140 - 141,992,331UniSTSRnor5.0
RGSC_v3.45139,718,527 - 139,718,718UniSTSRGSC3.4
Celera5131,271,527 - 131,271,718UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85138,025,892 - 138,026,656 (+)Marker Load Pipeline
mRatBN7.25132,740,566 - 132,741,330 (+)MAPPERmRatBN7.2
Rnor_6.05138,178,048 - 138,178,811NCBIRnor6.0
Rnor_5.05141,987,785 - 141,988,548UniSTSRnor5.0
RGSC_v3.45139,714,172 - 139,714,935UniSTSRGSC3.4
Celera5131,267,161 - 131,267,924UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,743,856 - 132,745,113 (+)MAPPERmRatBN7.2
Rnor_6.05138,181,338 - 138,182,594NCBIRnor6.0
Rnor_5.05141,991,075 - 141,992,331UniSTSRnor5.0
Celera5131,270,462 - 131,271,718UniSTS
Cytogenetic Map5q36.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064452   ⟹   ENSRNOP00000061340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)Ensembl
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083700   ⟹   ENSRNOP00000072351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,728,277 - 132,745,416 (+)Ensembl
Rnor_6.0 Ensembl5138,164,480 - 138,182,011 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106473   ⟹   ENSRNOP00000090216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,728,055 - 132,745,416 (+)Ensembl
RefSeq Acc Id: NM_138827   ⟹   NP_620182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,002,522 - 138,030,742 (+)NCBI
mRatBN7.25132,717,196 - 132,745,416 (+)NCBI
Rnor_6.05138,154,677 - 138,182,897 (+)NCBI
Rnor_5.05141,964,114 - 141,992,634 (+)NCBI
RGSC_v3.45139,690,801 - 139,719,021 (+)RGD
Celera5131,243,786 - 131,272,021 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41248 (Get FASTA)   NCBI Sequence Viewer  
  AAA41297 (Get FASTA)   NCBI Sequence Viewer  
  AAH61873 (Get FASTA)   NCBI Sequence Viewer  
  EDL90143 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061340.1
  ENSRNOP00000072351.2
  ENSRNOP00000090216.1
GenBank Protein P11167 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620182   ⟸   NM_138827
- UniProtKB: P11167 (UniProtKB/Swiss-Prot),   A6JZL0 (UniProtKB/TrEMBL),   A0A8I6ABD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072351   ⟸   ENSRNOT00000083700
Ensembl Acc Id: ENSRNOP00000061340   ⟸   ENSRNOT00000064452
Ensembl Acc Id: ENSRNOP00000090216   ⟸   ENSRNOT00000106473
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11167-F1-model_v2 AlphaFold P11167 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693972
Promoter ID:EPDNEW_R4497
Type:multiple initiation site
Name:Slc2a1_1
Description:solute carrier family 2 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,154,734 - 138,154,794EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3704 AgrOrtholog
BioCyc Gene G2FUF-40101 BioCyc
Ensembl Genes ENSRNOG00000007284 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064452.3 UniProtKB/Swiss-Prot
  ENSRNOT00000083700.2 UniProtKB/TrEMBL
  ENSRNOT00000106473.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598829 IMAGE-MGC_LOAD
InterPro Glu_transpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24778 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72306 IMAGE-MGC_LOAD
NCBI Gene 24778 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC2A1 RGD
PhenoGen Slc2a1 PhenoGen
PRINTS GLUCTRSPORT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007284 RatGTEx
  ENSRNOG00055013182 RatGTEx
  ENSRNOG00060016008 RatGTEx
  ENSRNOG00065017523 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2S2_RAT UniProtKB/TrEMBL
  A0A8I6ABD3 ENTREZGENE, UniProtKB/TrEMBL
  A6JZL0 ENTREZGENE, UniProtKB/TrEMBL
  GTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a1  solute carrier family 2 member 1  Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1    solute carrier family 2,member 1  Name updated 1299863 APPROVED
2002-06-10 Slc2a1  solute carrier family 2,member 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease insulin treatment causes a redistribution to heart plasma membrane 628382
gene_drugs Doxorubicin also known as adriamycin a highly effective antineoplastic drug induces cardiotoxicity thus stimulating this gene and regulating glucose uptake in heart cells 628382
gene_expression expressed in cardiac myocytes 628382
gene_expression chronic food restriction decreases the expression of cardiac mRNA  
gene_expression expressed in mammary epithelial cells during pregnancy and lactation; expression decreases during weaning 1299031
gene_homology protein has 97.6% identity to human hepatoma hexose carrier protein 729978
gene_process responsible for glucose entry into the brain  
gene_process may be responsible for constitutive or basal glucose uptake  
gene_process enhances glucose uptake in the heart after undernutrition due to the increased protein distribution to the surface membrane 628382
gene_process major glucose carrier in heart 628429
gene_process plays a role in placental glucose transport 1299030
gene_product member of the sugar transporter family  
gene_protein predicted to encode 492 amino acid protein 729978
gene_regulation chronic food restriction decreases the expression of cardiac mRNA 628382
gene_regulation increased glucose transport and increased transporter accessibility to substrate is induced by AMP activated protein kinase 730230
gene_regulation cis-acting regulatory element in 3'-untranslated region (CAE2181-2190) plays a role in increase in gene expression during glucose deprivation and hypoxia 1299029
gene_regulation transcription factor Sp1 may be involved in regulation of expression during trophoblast differentiation 1299030