RGD Reference Report - T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates. - Rat Genome Database

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T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates.

Authors: Santalucía, Tomàs  Palacín, Manuel  Zorzano, Antonio 
Citation: Santalucía T, etal., Mol Cell Endocrinol. 2006 Jun 7;251(1-2):9-16. Epub 2006 Apr 3.
RGD ID: 12879481
Pubmed: PMID:16581179   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mce.2006.02.016   (Journal Full-text)

Experimental hypothyroidism alters the expression of the GLUT1 and GLUT4 glucose transporters in brown adipose tissue, skeletal muscle and heart. Congenital hypothyroidism disrupts the development and function of the CNS, and the importance of GLUT1 for proper brain function has been dramatically evidenced in the cases of GLUT1 deficiency syndrome. Because of this, we hypothesised that the expression of GLUT1 and GLUT3, glucose transporters expressed in brain cortex, may be altered in congenital hypothyroidism. GLUT3 mRNA was induced during postnatal development whereas GLUT1 mRNA was initially repressed and further induced; both processes were essentially similar in control and hypothyroid animals. Under these conditions GLUT1 protein expression was reduced in cerebral cortex from 15-day-old hypothyroid neonates, which suggests the existence of post-transcriptional alterations. The most striking differences were observed when hypothyroid animals at different developmental stages were treated acutely with T(3). GLUT1 and GLUT3 mRNA expression behaved in opposite ways in response to treatment with the hormone. Furthermore, the behaviour of each glucose transporter isoform against T(3) was not uniform but changed alongside development. In all, our data show that the regulation of GLUT1 and GLUT3 in cerebral cortex is regulated by T(3) in a complex way and suggest that alterations in the expression of glucose transporters induced by hypothyroidism might have a functional impact on brain glucose uptake.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypothyroidism  ISOSlc2a1 (Rattus norvegicus)12879481; 12879481protein:decreased expression:cerebral cortexRGD 
hypothyroidism  IEP 12879481protein:decreased expression:cerebral cortexRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cerebral cortex development  IEP 12879481; 12879481 RGD 
response to Thyroglobulin triiodothyronine  IEP 12879481; 12879481 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc2a1  (solute carrier family 2 member 1)
Slc2a3  (solute carrier family 2 member 3)

Genes (Mus musculus)
Slc2a1  (solute carrier family 2 (facilitated glucose transporter), member 1)

Genes (Homo sapiens)
SLC2A1  (solute carrier family 2 member 1)


Additional Information