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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3704
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a1decreases expressionISOSLC2A1 (Homo sapiens)6480464CTDRotenone results in decreased expression of SLC2A1 mRNAPMID:36586010
Slc2a1decreases response to substanceISOSLC2A1 (Homo sapiens)6480464CTDSLC2A1 protein results in decreased susceptibility to RotenonePMID:10780954
Slc2a1increases expressionISOSlc2a1 (Mus musculus)6480464CTDRotenone results in increased expression of SLC2A1 mRNAPMID:30686998
Slc2a1multiple interactionsISOSLC2A1 (Homo sapiens)6480464CTDRotenone inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]; SLC2A1 protein inhibits the reaction [Rotenone results in increased activity of MAPK8 protein]PMID:10780954 PMID:19091749
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