RGD Reference Report - Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Association of glucose transporter 1 polymorphisms with type 2 diabetes in the Tunisian population.

Authors: Makni, K  Mnif, F  Boudawara, M  Hamza, N  Rekik, N  Abid, M  Rebai, A  Jarraya, F  Granier, C  Ayadi, H 
Citation: Makni K, etal., Diabetes Metab Res Rev. 2008 Oct;24(7):544-8.
RGD ID: 2312306
Pubmed: PMID:18613291   (View Abstract at PubMed)
DOI: DOI:10.1002/dmrr.866   (Journal Full-text)

BACKGROUND: T2DM is a complex metabolic disease. Genetic studies on T2DM have been of little help so far because several genetic association studies have shown conflicting results. In this study, we report the findings of a case-control study on three SNPs in the GLUT1 gene. For this, we investigated the association of GLUT1 genotypes and haplotypes with T2DM. RESEARCH DESIGN AND METHODS: All 273 T2DM subjects (cases) and 343 healthy subjects (controls) were genotyped using the polymerase chain reaction restriction fragment length polymorphism. RESULTS: Results showed that the GT genotype of XbaI SNP could increase the risk of susceptibility to T2DM to 2.4 and that TAT is a 'risk haplotype' conferring a risk of 3.4 to T2DM. CONCLUSION: The TAT haplotype of the GLUT1 gene confers susceptibility to T2DM in the Tunisian population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IAGP 2312306 RGD 
type 2 diabetes mellitus  ISOSLC2A1 (Homo sapiens)2312306; 2312306 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc2a1  (solute carrier family 2 member 1)

Genes (Mus musculus)
Slc2a1  (solute carrier family 2 (facilitated glucose transporter), member 1)

Genes (Homo sapiens)
SLC2A1  (solute carrier family 2 member 1)


Additional Information