Gene:	Shh ( Rattus norvegicus ) sonic hedgehog
Description:	plays a role in neurogenesis; regulates proliferation of adult hippocampal neural stem cells
Synonyms:	sonic hedgehog homolog (Drosophila); sonic hedgehog homolog (Drosophila) ; sonic hedgehog homolog, (Drosophila);
ArrayIDs:	5631592; 1387584_at; 5652292; 6499113; 5642416; 5957524; A_43_P11866; L27340_at; 6468410; A_44_P423704; 6130442; GE20432; 5939179; 5825742;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: SHH     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Shh     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Shh genome assembly 3.1 4 2200503 - 2209657     Rat Celera Assembly 4 3316537 - 3325690     RGSC genome assembly v3.4 4 2200504 - 2209657     Cytogenetic 4 q11 Mus musculus Shh Mouse genome assembly build 36.1 5 28783380 - 28793628     Cytogenetic 5 5 B1 Homo sapiens SHH human genome assembly 7 155095033 - 155104443     Human genome assembly build 36.2 7 155288319 - 155297728     Cytogenetic 7 q36   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  peptidase activity,  patched binding ...  (details...)
Biological Process	Note Reference important mitogen for cerebellar granule neuron precursors (GNPs) produced by the Purkinje neurons 628387 Gene Ontology heart looping,  branching morphogenesis of a tube,  lung development ...  (details...)
Cellular Component	Gene Ontology nucleus,  extracellular space,  membrane raft ...  (details...)
Disease	Note Reference mutations activating the Shh pathway are associated with medulloblastoma 628387 Ontology Myocardial Reperfusion Injury,  Hypothyroidism,  Holoprosencephaly (details...)
Pathway	Ontology altered Hedgehog signaling pathway,  Hedgehog signaling pathway (details...)
Regulation	Note Reference mitogenic activity stimulates DNA synthesis 628387
External Links
Databases	DATABASE ID SOURCE SMART: HintC IPI SMART: HintN IPI PROSITE: INTEIN_N_TER IPI UNIPARC: UPI0000135948 IPI KEGG Report: rno:29499 ENTREZGENE HomoloGene Group ID: 30961 ENTREZGENE Germonline: 3673 Pfam: Hint IPI Pfam: HH_signal IPI KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 04340 ENTREZGENE InterPro: Hedgehog_hint_C. IPI InterPro: Hedgehog_hint_N. IPI InterPro: HH_signal. IPI InterPro: Intein_splicing_site. IPI InterPro: Peptidase_C46. IPI InterPro: Peptidase_C46_hint. IPI InterPro: Hedgehog/DD-pept_Zn-bd. IPI Ensembl Protein: ENSRNOP00000008497 IPI IPI: IPI00211101 IPI Entrez Gene: Shh ENTREZGENE PIRSF: Peptidase_C46 IPI TIGR: TC214872 UniProt: SHH_RAT IPI UniProt: Q9R179_RAT IPI Ensembl Genes: ENSRNOG00000006120 IPI Superfamily-SCOP: Hedgehog_sig_N IPI PRINTS: SONICHHOG. IPI
Sequences	Nucleotide: NM_017221 Get FASTA Search GEO Profiles Nucleotide: L27340 Get FASTA Search GEO Profiles Nucleotide: AF162915 Get FASTA Search GEO Profiles Nucleotide: CH474057 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: Q9R179 Get FASTA Protein: Q63673 Get FASTA Protein: AAA20999 Get FASTA Protein: AAD45373 Get FASTA Protein: EDL86418 Get FASTA Protein: NP_058917 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 10432
References
Curated References	26 references in RGD related to Shh
Other References	42 other references at PubMed related to Shh
Database Information
RGD ID	3673
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-FEB-08: Shh sonic hedgehog Shh sonic hedgehog homolog (Drosophila) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 14-DEC-04: Shh sonic hedgehog homolog (Drosophila) sonic hedgehog homolog (Drosophila) APPROVED Symbol and Name status set to approved 1299863 10-JUN-02: Shh sonic hedgehog homolog (Drosophila) PROVISIONAL Name updated 70585