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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shh
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shhmultiple interactionsEXP 6480464CTDSHH protein inhibits the reaction [ochratoxin A affects the expression of SOX10 mRNA]; SHH protein inhibits the reaction [ochratoxin A results in decreased expression of CSPG4 mRNA]; SHH protein inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]; SHH protein inhibits the reaction [ochratoxin A results in decreased expression of MOG mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of ASCL1 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of CCND2 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DCX mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of DLL3 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of GLI1 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of HES5 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of MKI67 mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of NES mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of PDGFRA mRNA]; SHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of SOX2 mRNA]PMID:21703336 PMID:24792326
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