RGD Reference Report - Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance. - Rat Genome Database

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Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance.

Authors: Mastronardi, Fabrizio G  Min, Weixian  Wang, Huimin  Winer, Shawn  Dosch, Michael  Boggs, Joan M  Moscarello, Mario A 
Citation: Mastronardi FG, etal., J Immunol. 2004 May 15;172(10):6418-26.
RGD ID: 12801445
Pubmed: PMID:15128833   (View Abstract at PubMed)

Interferon-beta is a mainstay therapy of demyelinating diseases, but its effects are incomplete in human multiple sclerosis and several of its animal models. In this study, we demonstrate dramatic improvements of clinical, histological, and laboratory parameters in in vivo mouse models of demyelinating disease through combination therapy with IFN-beta plus vitamin B(12) cyanocobalamin (B(12)CN) in nonautoimmune primary demyelinating ND4 (DM20) transgenics, and in acute and chronic experimental autoimmune encephalomyelitis in SJL mice. Clinical improvement (p values <0.0001) was paralleled by near normal motor function, reduced astrocytosis, and reduced demyelination. IFN-beta plus B(12)CN enhanced in vivo and in vitro oligodendrocyte maturation. In vivo and in vitro altered expression patterns of reduced Notch-1 and enhanced expression of sonic hedgehog and its receptor were consistent with oligodendrocyte maturation and remyelination. IFN-beta-B(12)CN combination therapy may be promising for the treatment of multiple sclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
demyelinating disease treatmentISOPtch1 (Mus musculus)12801445; 12801445 RGD 
demyelinating disease treatmentIEP 12801445; 12801445 RGD 
demyelinating disease treatmentISOShh (Mus musculus)12801445; 12801445 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptch1  (patched 1)
Shh  (sonic hedgehog signaling molecule)

Genes (Mus musculus)
Ptch1  (patched 1)
Shh  (sonic hedgehog)

Genes (Homo sapiens)
PTCH1  (patched 1)
SHH  (sonic hedgehog signaling molecule)


Additional Information