Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shh
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shhmultiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]PMID:31612257
Shhdecreases activityISOSHH (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of SHH proteinPMID:23861973
Shhmultiple interactionsISOSHH (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]]PMID:23861973
Go Back to source page   Continue to Ontology report