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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3673
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shh
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shhaffects expressionISOSHH (Homo sapiens)6480464CTDsodium arsenite affects the expression of SHH mRNAPMID:20056578
Shhaffects methylationISOSHH (Homo sapiens)6480464CTDsodium arsenite affects the methylation of SHH genePMID:28589171
Shhdecreases expressionISOShh (Mus musculus)6480464CTDsodium arsenite results in decreased expression of SHH mRNAPMID:25448440
Shhdecreases response to substanceISOShh (Mus musculus)6480464CTDSHH protein results in decreased susceptibility to sodium arsenitePMID:25448440
Shhincreases activityISOShh (Mus musculus)6480464CTDsodium arsenite results in increased activity of SHH proteinPMID:20179202
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