Prkaa1 (protein kinase AMP-activated catalytic subunit alpha 1) - Rat Genome Database

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Gene: Prkaa1 (protein kinase AMP-activated catalytic subunit alpha 1) Rattus norvegicus
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Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
RGD ID: 3387
Description: Enables AMP-activated protein kinase activity and ATP binding activity. Involved in several processes, including cellular response to ethanol; cold acclimation; and fatty acid homeostasis. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Used to study type 2 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; autophagy pathway; INTERACTS WITH (+)-schisandrin B; (R,R)-tramadol; 1,2,3,4,7,8-Hexachlorodibenzodioxin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5'-AMP-activated protein kinase alpha-1 catalytic subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5-AMP-activated protein kinase alpha-1 catalytic subunit; ACACA kinase; acetyl-CoA carboxylase kinase; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPKalpha1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Prkaa1-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,967,766 - 56,003,450 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl255,967,351 - 56,003,450 (+)EnsemblGRCr8
mRatBN7.2254,240,298 - 54,275,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,240,137 - 54,275,978 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx261,345,189 - 61,382,747 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,403,869 - 59,441,427 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,416,258 - 54,451,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)Ensemblrn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera249,888,577 - 49,923,847 (+)NCBICelera
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pronuciferine  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-acanthoic acid  (ISO)
(-)-Arctigenin  (ISO)
(-)-matairesinol  (ISO)
(R,R)-tramadol  (EXP)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP)
3-methylglutaric acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
5-aminolevulinic acid  (EXP)
acadesine  (EXP,ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
amiodarone  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
ANTIMYCIN  (ISO)
apigenin  (ISO)
Arctiin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asperuloside  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Atpenin A5  (ISO)
bafilomycin A1  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-D-glucosamine  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
celecoxib  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dihydroxyacetone  (ISO)
dioscin  (EXP)
dioxygen  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
econazole  (ISO)
enalapril  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
formononetin  (ISO)
FR900359  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
gramine  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
Isobavachin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
luteolin  (ISO)
mangiferin  (EXP)
meloxicam  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
naproxen  (EXP)
nickel atom  (ISO)
nicorandil  (EXP)
nicotinamide  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP)
O-palmitoylcarnitine  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
orlistat  (EXP,ISO)
orotic acid  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
pravastatin  (ISO)
progesterone  (EXP)
Pseudolaric acid B  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
ruthenium red  (ISO)
Salidroside  (ISO)
Sanggenon C  (EXP)
SB 203580  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium dichromate  (EXP)
Sodium oleate  (ISO)
solasodine  (ISO)
steviol  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
syringin  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tramadol  (EXP)
triacsin C  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
U0126  (EXP)
WIN 55212-2  (ISO)
xylazine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
CAMKK-AMPK signaling cascade  (IEA,ISO)
cellular response to calcium ion  (IEA,IMP,ISO)
cellular response to ethanol  (IEP)
cellular response to glucose starvation  (IBA,IEA,ISO,ISS)
cellular response to glucose stimulus  (IEA,IMP,ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular response to nutrient levels  (IEA,ISO,ISS)
cellular response to oxidative stress  (IEA,ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to starvation  (IEA,ISO)
cellular response to stress  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEP)
cholesterol biosynthetic process  (IEA)
cholesterol metabolic process  (IEA)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
cold acclimation  (IDA)
energy homeostasis  (IDA,IEA,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid homeostasis  (IDA,IEA)
fatty acid metabolic process  (IEA)
fatty acid oxidation  (ISO)
glucose homeostasis  (IEA,ISO,ISS)
glucose metabolic process  (ISO)
lipid biosynthetic process  (IEA,ISO,ISS)
lipid droplet disassembly  (ISO,ISS)
lipid metabolic process  (IEA)
motor behavior  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of ferroptosis  (ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (IEA,ISO,ISS)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of lipid catabolic process  (IEA,ISO,ISS)
negative regulation of TOR signaling  (IEA,ISO,ISS)
negative regulation of TORC1 signaling  (IBA,IEA,ISO,ISS)
negative regulation of translation  (NAS)
neuron cellular homeostasis  (IEA,ISO)
positive regulation of adipose tissue development  (IEA,ISO)
positive regulation of autophagy  (IBA,IEA,ISO,ISS)
positive regulation of cell population proliferation  (IDA)
positive regulation of D-glucose import across plasma membrane  (NAS)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid oxidation  (NAS)
positive regulation of gene expression  (ISO)
positive regulation of gluconeogenesis  (NAS)
positive regulation of glycolytic process  (IDA,IEA)
positive regulation of mitochondrial transcription  (IEA,ISO)
positive regulation of protein localization  (IEA,ISO)
positive regulation of protein targeting to mitochondrion  (IEA,ISO)
positive regulation of skeletal muscle tissue development  (ISO)
positive regulation of T cell activation  (IEA,ISO)
positive regulation of T cell mediated immune response to tumor cell  (IEA,ISO)
protein localization to lipid droplet  (IBA,IEA,ISO,ISS)
protein localization to membrane  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (IDA,NAS)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of microtubule cytoskeleton organization  (IEA,ISO)
regulation of peptidyl-serine phosphorylation  (ISO)
regulation of stress granule assembly  (IEA,ISO)
regulation of vascular permeability  (IEA,ISO)
regulation of vesicle-mediated transport  (IMP)
response to activity  (IDA)
response to caffeine  (IDA,IEA)
response to estrogen  (IEP)
response to gamma radiation  (IEA,ISO,ISS)
response to hydrogen peroxide  (IEA,ISO)
response to UV  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
rhythmic process  (IEA)
steroid biosynthetic process  (IEA)
steroid metabolic process  (IEA)
sterol biosynthetic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component
apical plasma membrane  (IDA)
axon  (IEA,IMP,ISO)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IDA,IEA,ISO,TAS)
dendrite  (IEA,IMP,ISO)
neuronal cell body  (IEA,IMP,ISO)
nuclear speck  (IEA,ISO)
nucleotide-activated protein kinase complex  (IBA,IDA,IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. Bolster DR, etal., J Biol Chem 2002 Jul 5;277(27):23977-80.
2. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Cammisotto PG, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. doi: 10.1152/ajprenal.00373.2007. Epub 2008 Feb 6.
3. Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism. Carling D, etal., J Biol Chem 1994 Apr 15;269(15):11442-8.
4. Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. Chen L, etal., Exp Mol Med. 2010 Feb 11.
5. Expression and significance of lipin1 and AMPKalpha in hepatic insulin resistance in diet-induced insulin resistance rats. Chen SH, etal., Exp Clin Endocrinol Diabetes. 2012 Feb;120(2):84-8. Epub 2012 Jan 9.
6. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Cheung PC, etal., Biochem J. 2000 Mar 15;346 Pt 3:659-69.
7. A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung. Crawford RM, etal., Biochem J. 2005 Nov 15;392(Pt 1):201-9.
8. Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Egawa T, etal., Metabolism. 2009 Nov;58(11):1609-17. Epub 2009 Jul 15.
9. Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Fryer LG, etal., Biochem J. 2002 Apr 1;363(Pt 1):167-74.
10. Hydrogen peroxide induces expression and activation of AMP-activated protein kinase in a dental pulp cell line. Fukuyama Y, etal., Int Endod J. 2008 Mar;41(3):197-203. Epub 2007 Dec 10.
11. Hypoxia induces expression and activation of AMPK in rat dental pulp cells. Fukuyama Y, etal., J Dent Res. 2007 Sep;86(9):903-7.
12. Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes. Gaidhu MP, etal., Mol Endocrinol. 2010 Jul;24(7):1434-40. Epub 2010 May 25.
13. Catalytic subunits of the porcine and rat 5'-AMP-activated protein kinase are members of the SNF1 protein kinase family. Gao G, etal., Biochim Biophys Acta 1995 Apr 6;1266(1):73-82.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. The AMP-activated protein kinase pathway--new players upstream and downstream. Hardie DG J Cell Sci. 2004 Nov 1;117(Pt 23):5479-87.
17. Management of cellular energy by the AMP-activated protein kinase system. Hardie DG, etal., FEBS Lett. 2003 Jul 3;546(1):113-20.
18. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Hawley SA, etal., J Biol. 2003;2(4):28. Epub 2003 Sep 24.
19. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Horman S, etal., Curr Biol. 2002 Aug 20;12(16):1419-23.
20. AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice. Hulo S, etal., Respir Res. 2011 May 19;12:64.
21. AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). Iseli TJ, etal., J Biol Chem. 2005 Apr 8;280(14):13395-400. Epub 2005 Jan 28.
22. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. Ishii H, etal., J Hepatol. 2009 Mar;50(3):562-71. Epub 2008 Dec 27.
23. Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. Javadov S, etal., J Mol Cell Cardiol. 2009 Jun;46(6):998-1007. doi: 10.1016/j.yjmcc.2008.12.023. Epub 2009 Jan 20.
24. Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. Ju TC, etal., J Cell Biol. 2011 Jul 25;194(2):209-27. Epub 2011 Jul 18.
25. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. Kawaguchi T, etal., J Biol Chem 2002 Feb 8;277(6):3829-35.
26. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
27. Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Koh HJ, etal., Biochem J. 2007 May 1;403(3):473-81.
28. Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat. Lakshmanan AP, etal., Free Radic Res. 2011 Jul;45(7):788-95. Epub 2011 May 9.
29. Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Li J, etal., Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1927-34. Epub 2006 Apr 28.
30. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
31. Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Liangpunsakul S, etal., Arch Biochem Biophys. 2009 May 1;485(1):10-5. Epub 2009 Feb 21.
32. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Marsin AS, etal., Curr Biol. 2000 Oct 19;10(20):1247-55.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. Mitchelhill KI, etal., J Biol Chem 1994 Jan 28;269(4):2361-4.
35. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Nath N, etal., Biochem Biophys Res Commun. 2009 Aug 14;386(1):16-20. Epub 2009 May 30.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Sample V, etal., Mol Biol Cell. 2015 May 15;26(10):1935-46. doi: 10.1091/mbc.E14-02-0764. Epub 2015 Mar 18.
42. Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats. Seo E, etal., Korean J Physiol Pharmacol. 2009 Dec;13(6):449-54. Epub 2009 Dec 31.
43. Genetic variation in genes involved in hormones, inflammation, and energetic factors and breast cancer risk in an admixed population. Slattery M, etal., Carcinogenesis. 2012 May 4.
44. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. Slattery ML, etal., Carcinogenesis. 2010 Sep;31(9):1604-11. Epub 2010 Jul 9.
45. Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. Stapleton D, etal., J Biol Chem 1994 Nov 25;269(47):29343-6.
46. Mammalian AMP-activated protein kinase subfamily. Stapleton D, etal., J Biol Chem 1996 Jan 12;271(2):611-4.
47. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
48. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
49. Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. Velasco G, etal., FEBS Lett. 1998 Nov 20;439(3):317-20.
50. Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1alpha and AMPKalpha. Vucetic M, etal., Biochim Biophys Acta. 2011 Dec;1810(12):1252-61. Epub 2011 Sep 16.
51. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub .
52. The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. Woods A, etal., FEBS Lett. 1996 Nov 18;397(2-3):347-51.
53. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Xiao B, etal., Nature. 2007 Sep 27;449(7161):496-500. Epub 2007 Sep 12.
54. Structure of mammalian AMPK and its regulation by ADP. Xiao B, etal., Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.
55. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. Yang Z, etal., J Biol Chem. 2010 Jun 18;285(25):19051-9. Epub 2010 Apr 26.
56. The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Galphaq-mediated intracellular GLUT4 vesicle distribution. Yuasa T, etal., Endocr J. 2009 Jun;56(3):345-59. Epub 2009 Jan 9.
57. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
PMID:10862786   PMID:11165240   PMID:11546797   PMID:12802337   PMID:15153111   PMID:15878856   PMID:16054095   PMID:16308421   PMID:16316631   PMID:16340011   PMID:16943243   PMID:17023420  
PMID:17028174   PMID:17488477   PMID:18381428   PMID:18439900   PMID:18556591   PMID:18941912   PMID:19049348   PMID:19116341   PMID:19380482   PMID:19625676   PMID:19833968   PMID:19933272  
PMID:19940039   PMID:20057367   PMID:20349193   PMID:20615388   PMID:20647423   PMID:20660302   PMID:20841353   PMID:20844250   PMID:21232561   PMID:21258367   PMID:21352901   PMID:21389275  
PMID:21436401   PMID:21459323   PMID:21481774   PMID:21562306   PMID:21680893   PMID:21730292   PMID:21994947   PMID:22012985   PMID:22124463   PMID:22194917   PMID:22230191   PMID:22452514  
PMID:22560150   PMID:22582096   PMID:22610379   PMID:22941749   PMID:23024365   PMID:23095119   PMID:23184732   PMID:23283301   PMID:23479225   PMID:23750537   PMID:23788766   PMID:23926128  
PMID:23999859   PMID:24097562   PMID:24566685   PMID:24625528   PMID:24656927   PMID:24739942   PMID:24801390   PMID:25117440   PMID:25687571   PMID:25826445   PMID:26103054   PMID:26136559  
PMID:26196303   PMID:26498380   PMID:27430620   PMID:28041982   PMID:28147330   PMID:28482939   PMID:28686615   PMID:30132885   PMID:30291215   PMID:30348767   PMID:31100477   PMID:31526389  
PMID:32305957   PMID:33640872   PMID:36240643   PMID:37627248  


Genomics

Comparative Map Data
Prkaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,967,766 - 56,003,450 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl255,967,351 - 56,003,450 (+)EnsemblGRCr8
mRatBN7.2254,240,298 - 54,275,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,240,137 - 54,275,978 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx261,345,189 - 61,382,747 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,403,869 - 59,441,427 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,416,258 - 54,451,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)Ensemblrn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera249,888,577 - 49,923,847 (+)NCBICelera
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Cytogenetic Map2q16NCBI
PRKAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,759,389 - 40,798,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl540,759,389 - 40,798,374 (-)Ensemblhg38GRCh38
GRCh37540,759,491 - 40,798,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
T2T-CHM13v2.0541,015,789 - 41,054,877 (-)NCBIT2T-CHM13v2.0
Prkaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)Ensemblmm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBIMGSCv36mm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
Prkaa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)Ensembl
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
PRKAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,533,595 - 69,577,363 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,686,712 - 67,730,994 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,627,844 - 74,666,505 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)EnsemblpanPan2panpan1.1
PRKAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha468,255,490 - 68,291,515 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0469,085,598 - 69,121,628 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl469,085,149 - 69,121,622 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,844,836 - 68,880,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,957,934 - 68,993,962 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,496,965 - 69,533,038 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,804,969 - 1,843,380 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,324 - 25,783,707 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkaa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475914,142,956 - 14,171,718 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkaa1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13175,143,391 - 175,180,402 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkaa1
192 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:79
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000017626
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017626   ⟹   ENSRNOP00000017626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl255,967,351 - 56,003,450 (+)Ensembl
mRatBN7.2 Ensembl254,240,137 - 54,275,978 (+)Ensembl
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099171   ⟹   ENSRNOP00000085006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl255,979,458 - 56,003,450 (+)Ensembl
mRatBN7.2 Ensembl254,252,005 - 54,275,978 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117002   ⟹   ENSRNOP00000085394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl255,973,382 - 56,003,450 (+)Ensembl
mRatBN7.2 Ensembl254,240,307 - 54,275,978 (+)Ensembl
RefSeq Acc Id: NM_019142   ⟹   NP_062015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8255,967,775 - 56,003,450 (+)NCBI
mRatBN7.2254,240,298 - 54,275,978 (+)NCBI
Rnor_6.0254,857,688 - 54,893,404 (+)NCBI
Rnor_5.0273,882,080 - 73,917,812 (+)NCBI
RGSC_v3.4254,327,821 - 54,360,462 (+)RGD
Celera249,888,577 - 49,923,847 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103097   ⟹   XP_038959025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8255,967,766 - 56,003,450 (+)NCBI
mRatBN7.2254,256,129 - 54,275,978 (+)NCBI
RefSeq Acc Id: XM_063282506   ⟹   XP_063138576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8255,967,766 - 56,003,450 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062015 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959025 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138576 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52355 (Get FASTA)   NCBI Sequence Viewer  
  EDL75727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017626
  ENSRNOP00000017626.3
GenBank Protein P54645 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062015   ⟸   NM_019142
- UniProtKB: P54645 (UniProtKB/Swiss-Prot),   A6KGD8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017626   ⟸   ENSRNOT00000017626
RefSeq Acc Id: XP_038959025   ⟸   XM_039103097
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GCD0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085394   ⟸   ENSRNOT00000117002
Ensembl Acc Id: ENSRNOP00000085006   ⟸   ENSRNOT00000099171
RefSeq Acc Id: XP_063138576   ⟸   XM_063282506
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GCD0 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54645-F1-model_v2 AlphaFold P54645 1-559 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691167
Promoter ID:EPDNEW_R1692
Type:multiple initiation site
Name:Prkaa1_1
Description:protein kinase AMP-activated catalytic subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0254,857,700 - 54,857,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3387 AgrOrtholog
BioCyc Gene G2FUF-54177 BioCyc
Ensembl Genes ENSRNOG00000012799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017626 ENTREZGENE
  ENSRNOT00000017626.6 UniProtKB/Swiss-Prot
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  Kinase associated domain 1, KA1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AMPK_C UniProtKB/Swiss-Prot
  AMPKA1_C UniProtKB/Swiss-Prot
  KA1/Ssp2_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PRKAA1/2_AID UniProtKB/Swiss-Prot
  PRKAA1_UBA UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:65248 UniProtKB/Swiss-Prot
NCBI Gene 65248 ENTREZGENE
PANTHER ACETYL-COA CARBOXYLASE KINASE UniProtKB/Swiss-Prot
  MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/Swiss-Prot
Pfam AdenylateSensor UniProtKB/Swiss-Prot
  AMPK_alpha_AID UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PharmGKB PRKAA1 RGD
PhenoGen Prkaa1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012799 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103243 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC215672
UniProt A0A8I5ZZZ5_RAT UniProtKB/TrEMBL
  A0A8I6GCD0 ENTREZGENE, UniProtKB/TrEMBL
  A6KGD8 ENTREZGENE, UniProtKB/TrEMBL
  AAPK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkaa1  protein kinase AMP-activated catalytic subunit alpha 1  Prkaa1  protein kinase, AMP-activated, alpha 1 catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkaa1  protein kinase, AMP-activated, alpha 1 catalytic subunit      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 548 amino acids; 63 kDa 69937