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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1decreases phosphorylationEXP 6480464CTDCadmium Chloride results in decreased phosphorylation of PRKAA1 proteinPMID:21195169
Prkaa1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of PRKAA1 proteinPMID:21195169
Prkaa1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]PMID:21195169
Prkaa1decreases phosphorylationISOPRKAA1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased phosphorylation of PRKAA1 proteinPMID:21195169
Prkaa1increases expressionISOPRKAA1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of PRKAA1 proteinPMID:21195169
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]PMID:21195169
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