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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1decreases phosphorylationISOPrkaa1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased phosphorylation of PRKAA1 proteinPMID:24465016
Prkaa1decreases phosphorylationISOPRKAA1 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased phosphorylation of PRKAA1 proteinPMID:35331853
Prkaa1multiple interactionsISOPrkaa1 (Mus musculus)6480464CTDAICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; Lipopolysaccharides promotes the reaction [formononetin results in increased phosphorylation of PRKAA1 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]PMID:24465016 PMID:37269934
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTDNLRP3 protein inhibits the reaction [PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; NLRP3 protein inhibits the reaction [PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; PRKAA1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]; PRKAA1 protein promotes the reaction [puerarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]PMID:35331853
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