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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:18406
Term: AICA ribonucleotide
Definition: A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Chemical ID: MESH:C031143
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1increases activityEXP 6480464CTDAICA ribonucleotide results in increased activity of PRKAA1 proteinPMID:12519745
Prkaa1increases phosphorylationEXP 6480464CTDAICA ribonucleotide results in increased phosphorylation of PRKAA1 proteinPMID:16020477
Prkaa1multiple interactionsEXP 6480464CTD[AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesterone; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; AICA ribonucleotide inhibits the reaction [Sodium Chloride, Dietary results in increased expression of PRKAA1 mRNA]PMID:16020477 PMID:20349193 PMID:21195169
Prkaa1increases expressionISOPRKAA1 (Homo sapiens)6480464CTDAICA ribonucleotide results in increased expression of PRKAA1 protein modified formPMID:25743752
Prkaa1increases phosphorylationISOPrkaa1 (Mus musculus)6480464CTDAICA ribonucleotide results in increased phosphorylation of PRKAA1 proteinPMID:24465016 PMID:28298333
Prkaa1increases phosphorylationISOPRKAA1 (Homo sapiens)6480464CTDAICA ribonucleotide results in increased phosphorylation of PRKAA1 proteinPMID:23266269
Prkaa1multiple interactionsISOPrkaa1 (Mus musculus)6480464CTDAICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of PRKAA1 protein]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein]PMID:24465016
Prkaa1multiple interactionsISOPRKAA1 (Homo sapiens)6480464CTDAICA ribonucleotide promotes the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]; Quercetin promotes the reaction [AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 protein]PMID:16873680 PMID:19293639 PMID:21205922
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