PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) Chlorocebus sabaeus
Analyze
Symbol: PRKAA1
Name: protein kinase AMP-activated catalytic subunit alpha 1
RGD ID: 18554959
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); kinase binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); amenorrhea (ortholog); breast cancer (ortholog); FOUND IN apical plasma membrane (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
CAMKK-AMPK signaling cascade  (IEA)
cellular response to calcium ion  (IEA)
cellular response to ethanol  (ISO)
cellular response to glucose starvation  (IEA)
cellular response to glucose stimulus  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nutrient levels  (IEA)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (ISO)
cholesterol biosynthetic process  (IEA)
chromatin remodeling  (IEA)
cold acclimation  (ISO)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
fatty acid oxidation  (IEA,ISO)
glucose homeostasis  (IEA)
glucose metabolic process  (IEA,ISO)
intracellular signal transduction  (IEA)
lipid biosynthetic process  (IEA)
lipid droplet disassembly  (IEA,ISO)
motor behavior  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of hepatocyte apoptotic process  (IEA)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid catabolic process  (IEA)
negative regulation of TOR signaling  (IEA)
negative regulation of TORC1 signaling  (IEA)
negative regulation of tubulin deacetylation  (IEA)
neuron cellular homeostasis  (IEA)
positive regulation of adipose tissue development  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of mitochondrial transcription  (IEA)
positive regulation of peptidyl-lysine acetylation  (IEA)
positive regulation of protein localization  (IEA)
positive regulation of protein targeting to mitochondrion  (IEA)
positive regulation of skeletal muscle tissue development  (IEA,ISO)
protein localization to lipid droplet  (IEA)
protein phosphorylation  (ISO)
regulation of circadian rhythm  (IEA)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of peptidyl-serine phosphorylation  (IEA,ISO)
regulation of stress granule assembly  (IEA)
regulation of vesicle-mediated transport  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to estrogen  (ISO)
response to gamma radiation  (IEA)
response to hydrogen peroxide  (IEA)
response to UV  (IEA)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKAA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PRKAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,759,389 - 40,798,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl540,759,389 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh37540,759,491 - 40,798,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36Build 36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
T2T-CHM13v2.0541,015,789 - 41,054,877 (-)NCBIT2T-CHM13v2.0
Prkaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)EnsemblGRCm39 Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBIMGSCv36mm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
Prkaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8255,967,766 - 56,003,450 (+)NCBIGRCr8
mRatBN7.2254,240,298 - 54,275,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,240,137 - 54,275,978 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx261,345,189 - 61,382,747 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,403,869 - 59,441,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,416,258 - 54,451,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBICelera
Cytogenetic Map2q16NCBI
Prkaa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
PRKAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,533,595 - 69,577,363 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,686,712 - 67,730,994 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,627,844 - 74,666,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)Ensemblpanpan1.1panPan2
PRKAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,255,490 - 68,291,515 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0469,085,598 - 69,121,628 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl469,085,149 - 69,121,622 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,844,836 - 68,880,871 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0468,957,934 - 68,993,962 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,496,965 - 69,533,038 (+)NCBIUU_Cfam_GSD_1.0
Prkaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,804,969 - 1,843,380 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,324 - 25,783,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Prkaa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475914,142,956 - 14,171,718 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_007961468   ⟹   XP_007959659
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1439,516,307 - 39,553,627 (-)NCBI
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007961469   ⟹   XP_007959660
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1439,516,307 - 39,553,558 (-)NCBI
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,034 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037990785   ⟹   XP_037846713
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607129,947,700 - 29,980,047 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007959659 (Get FASTA)   NCBI Sequence Viewer  
  XP_007959660 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846713 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012966.1
Reference Protein Sequences
RefSeq Acc Id: XP_007959659   ⟸   XM_007961468
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RWH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007959660   ⟸   XM_007961469
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RWH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846713   ⟸   XM_037990785
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016919 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015012.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
  Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AMPK_C UniProtKB/TrEMBL
  KA1/Ssp2_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PRKAA1/2_AID UniProtKB/TrEMBL
  PRKAA1_UBA UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRKAA1 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam AdenylateSensor UniProtKB/TrEMBL
  AMPK_alpha_AID UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP KA1-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0A0D9RWH7 ENTREZGENE, UniProtKB/TrEMBL