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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3387
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa1increases expressionEXP 15090804RGD17alpha-ethynylestradiol increases expression of Prkaa1 mRNA and protein in primary hepatocytes 
Prkaa1increases phosphorylationEXP 15090804RGD17alpha-ethynylestradiol increases phosphorylation of Prkaa1 in primary hepatocytes; increases phosphorylated protein levels in nuclear and cytosolic fractions 
Prkaa1affects localizationEXP 6480464CTDEthinyl Estradiol affects the localization of PRKAA1 proteinPMID:27090119
Prkaa1multiple interactionsEXP 6480464CTDEthinyl Estradiol results in increased phosphorylation of and affects the localization of PRKAA1 protein; PRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; PRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]; PRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 protein]; PRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; PRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]; PRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]PMID:27090119
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