Il18 (interleukin 18) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Il18 (interleukin 18) Rattus norvegicus
Analyze
Symbol: Il18
Name: interleukin 18
RGD ID: 2889
Description: Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane and extracellular space. Used to study brain edema; heart disease; status epilepticus; steatotic liver disease; and vasculitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; ischemia (multiple); lung disease (multiple); and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; biliary atresia; liver disease (multiple); and vasculitis (multiple). Orthologous to human IL18 (interleukin 18); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IFN-gamma-inducing factor; IL-1 gamma; IL-18; interferon gamma-inducing factor; interferon-gamma-inducing factor; interleukin-1 gamma; interleukin-18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,809,592 - 59,831,286 (+)EnsemblGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)Ensemblrn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,474,845 - 50,479,055 (+)NCBICelera
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
alopecia areata  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atherosclerosis  (IEP,ISO)
atopic dermatitis  (ISO,ISS)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Binge Drinking  (IEP)
brain edema  (IDA)
Brain Injuries  (IMP,ISO)
brain ischemia  (IEP,ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Carcinoma, Lewis Lung  (ISO)
cardiac arrest  (IEP)
Cardiomegaly  (ISO)
Carotid Artery Injuries  (IEP,IMP)
cataract  (IEP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
cystitis  (IEP)
dermatitis  (ISO)
dermatomyositis  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Drug Eruptions  (ISO)
Eczema  (ISO)
Edema  (IMP)
Embryo Loss  (IEP)
Experimental Arthritis  (IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP,IMP)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
Experimental Radiation Injuries  (ISO)
eye disease  (ISO)
familial Mediterranean fever  (ISO)
glomerulonephritis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
heart disease  (IMP)
heart valve disease  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
high grade glioma  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IMP)
Hyperoxia  (IDA)
Hyperphagia  (ISO)
IgA glomerulonephritis  (ISO)
Immediate Hypersensitivity  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (IEP,ISO)
intrahepatic cholestasis of pregnancy  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (IEP)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (IMP)
Legionnaires' disease  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (IEP)
Liver Injury  (IEP,ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
Macrophage Activation Syndrome  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (IEP,ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (IEP)
Myocardial Reperfusion Injury  (IDA,ISO)
myositis  (ISO)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
Nontuberculous Mycobacterium Infections  (ISO)
obesity  (IEP,ISO)
Oral Lichen Planus  (ISO)
Pain  (IDA)
pancreatitis  (IEP)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (IEP,ISO)
Peripheral Nerve Injuries  (IEP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (IEP,ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (IEP,ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retinal Neovascularization  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
Schistosomiasis Japonica  (ISO)
Seasonal Allergic Rhinitis  (ISO)
severe acute respiratory syndrome  (ISO)
Sjogren's syndrome  (ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (IDA,IEP)
Staphylococcal Skin Infections  (ISO)
status epilepticus  (IDA)
steatotic liver disease  (IDA)
stroke  (IEP)
strongyloidiasis  (ISO)
temporal arteritis  (ISO)
Tibial Fractures  (IEP)
Transplant Rejection  (IMP)
type 1 diabetes mellitus  (ISO)
urinary tract infection  (IEP)
urticaria  (ISO)
uveitis  (IEP)
vasculitis  (IDA)
Venous Thrombosis  (IEP)
visceral leishmaniasis  (ISO)
Wallerian Degeneration  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
4-nitrobenzyl bromide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (ISO)
A-967079  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP,ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP,ISO)
atrazine  (ISO)
aucubin  (ISO)
aurantio-obtusin  (ISO)
Azoxymethane  (ISO)
baicalin  (ISO)
bellidifolin  (ISO)
Belnacasan  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzocaine  (ISO)
benzylpenicillin  (ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
beta-cyclodextrin  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
boric acid  (EXP)
boron atom  (EXP)
BQ 123  (EXP)
Brevianamide A  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
cerium trichloride  (ISO)
ceruletide  (EXP)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cimetidine  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citral  (ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
Curcumol  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (ISO)
dextran sulfate  (EXP,ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylamine  (ISO)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
dimethyl fumarate  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
docosahexaenoic acid  (EXP)
doxorubicin  (EXP)
drometrizole  (ISO)
elemental boron  (EXP)
emodin  (ISO)
empagliflozin  (EXP)
eplerenone  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
Evodiamine  (EXP)
famotidine  (ISO)
fasudil  (EXP)
felodipine  (EXP)
ferulic acid  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside Rb1  (EXP,ISO)
glucose  (EXP,ISO)
glyburide  (EXP,ISO)
glyoxal  (ISO)
gossypin  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
GSK2193874  (ISO)
hemin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
histamine  (ISO)
Honokiol  (ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxysafflor yellow A  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
ICI 118551  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
JTE-013  (EXP)
Jujuboside A  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
lixisenatide  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
m-xylene  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
manumycin A  (ISO)
melatonin  (ISO)
melittin  (ISO)
mesalamine  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nifuroxazide  (EXP)
nigericin  (ISO)
nilotinib  (ISO)
nitrofen  (EXP)
NMN zwitterion  (EXP,ISO)
Nonylphenol  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Palbinone  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
pentachlorophenol  (ISO)
pentane-2,3-dione  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenytoin  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
prednisolone  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
propofol  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
rutin  (EXP)
Salidroside  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
scutellarin  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sphingosine 1-phosphate  (EXP)
spironolactone  (EXP)
sterigmatocystin  (ISO)
streptozocin  (EXP,ISO)
sulfamic acid  (ISO)
sulfasalazine  (EXP,ISO)
sulfur dioxide  (EXP)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
ubiquinone-0  (ISO)
undecan-2-one  (ISO)
uranium atom  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vanillin  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
wedelolactone  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc protoporphyrin  (ISO)
zirconium atom  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO,ISS)
cell population proliferation  (ISO)
cellular response to cAMP  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to lipopolysaccharide  (IBA,IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to peptide hormone stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
cholesterol homeostasis  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA)
defense response to Gram-positive bacterium  (IEA,ISO,ISS)
detection of mechanical stimulus involved in sensory perception of pain  (IDA)
digestive tract morphogenesis  (IEP)
establishment of skin barrier  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
immune response  (IBA,IEA)
inflammatory response  (IBA,IEA,ISO)
interleukin-18-mediated signaling pathway  (IEA,ISO,ISS)
learning or memory  (TAS)
liver regeneration  (IEP)
lung development  (IEP)
natural killer cell activation  (ISO)
natural killer cell mediated cytotoxicity  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of neutrophil apoptotic process  (IMP)
negative regulation of peptidyl-tyrosine phosphorylation  (IMP)
neutrophil activation  (ISO)
osteoblast differentiation  (IEP)
positive regulation of activated T cell proliferation  (IEA,ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel remodeling  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (IMP)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of cytokine production  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA,ISO)
positive regulation of hepatocyte proliferation  (IDA)
positive regulation of inflammatory response  (IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEP)
positive regulation of interleukin-17 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IDA)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of male germ cell proliferation  (IDA)
positive regulation of natural killer cell proliferation  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of NK T cell proliferation  (IEA,ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
positive regulation of superoxide anion generation  (IMP)
positive regulation of T-helper 1 cell cytokine production  (IEA,ISO,ISS)
positive regulation of T-helper 2 cell differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of type II interferon production  (IEA,ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular permeability  (IMP)
regulation of cell adhesion  (IEA,ISO,ISS)
regulation of circadian sleep/wake cycle, non-REM sleep  (TAS)
response to hyperoxia  (IEP)
response to hypoxia  (IMP)
response to peptide hormone  (IEP)
signal transduction  (IEA)
sleep  (IDA)
T-helper 1 type immune response  (IEA,ISO,ISS)
triglyceride homeostasis  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Serum IL-18 levels in tuberculosis: comparison with pneumonia, lung cancer and healthy controls. Akgun M, etal., Respirology. 2005 Jun;10(3):295-9.
2. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. Akhtar S, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G340-7. Epub 2009 Jun 4.
3. Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Akhtar S, etal., Mol Med. 2011 Jan-Feb;17(1-2):88-94. doi: 10.2119/molmed.2010.00080. Epub 2010 Sep 10.
4. Serum IL-18 levels in patients with type 1 diabetes: relations to metabolic control and microvascular complications. Altinova AE, etal., Cytokine. 2008 May;42(2):217-21. doi: 10.1016/j.cyto.2008.02.006. Epub 2008 Mar 24.
5. Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. Alves ABRM, etal., Med Mycol. 2018 Apr 1;56(3):332-343. doi: 10.1093/mmy/myx050.
6. Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. An P, etal., J Infect Dis. 2008 Oct 15;198(8):1159-65. doi: 10.1086/592047.
7. Serum interleukins 12 and 18 and immunoglobulin E concentrations and allergic symptoms in Japanese schoolchildren. Ando M and Shima M, J Investig Allergol Clin Immunol. 2007;17(1):14-9.
8. Upregulation of Th1 cytokine profile (IL-12, IL-18) in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis. Antoniou KM, etal., J Interferon Cytokine Res. 2006 Jun;26(6):400-5.
9. Interleukin-18 gene polymorphisms and haplotypes in patients with oral lichen planus: a study in an ethnic Chinese cohort. Bai J, etal., Tissue Antigens. 2007 Nov;70(5):390-7. Epub 2007 Sep 14.
10. Association of genetic variants in the interleukin-18 gene promoter with risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus infection. Bakr NM, etal., IUBMB Life. 2018 Feb;70(2):165-174. doi: 10.1002/iub.1714. Epub 2018 Jan 17.
11. The P2X7 receptor-inflammasome complex has a role in modulating the inflammatory response in primary Sjogren's syndrome. Baldini C, etal., J Intern Med. 2013 Nov;274(5):480-9. doi: 10.1111/joim.12115. Epub 2013 Aug 17.
12. IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2. Blease K, etal., Inflamm Res. 2001 Nov;50(11):552-60.
13. Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease. Borai IH, etal., J Clin Transl Hepatol. 2017 Jun 28;5(2):109-118. doi: 10.14218/JCTH.2017.00004. Epub 2017 Jun 7.
14. Immunomodulatory role of endogenous interleukin-18 in gamma interferon-mediated resolution of replicative Legionella pneumophila lung infection. Brieland JK, etal., Infect Immun. 2000 Dec;68(12):6567-73.
15. Hypothermia after cardiac arrest does not alter serum inflammatory markers. Callaway CW, etal., Crit Care Med. 2008 Sep;36(9):2607-12.
16. Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs. Cardenas S, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L334-44. Epub 2010 Jun 11.
17. Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndrome. Castelar L, etal., Tissue Antigens. 2010 Aug;76(2):126-30. doi: 10.1111/j.1399-0039.2010.01471.x. Epub 2010 Mar 14.
18. TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Chandrasekar B, etal., Biochem Biophys Res Commun. 2003 Apr 18;303(4):1152-8.
19. High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection. Chattergoon MA, etal., J Infect Dis. 2011 Dec 1;204(11):1730-40. doi: 10.1093/infdis/jir642. Epub 2011 Oct 7.
20. Association of interleukin 18 gene polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery. Chen S, etal., Tissue Antigens. 2010 Sep;76(3):245-9.
21. Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease. Chen SY, etal., J Clin Lab Anal. 2009;23(2):71-6. doi: 10.1002/jcla.20292.
22. Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance. Cheong JY, etal., Dig Dis Sci. 2010 Apr;55(4):1113-9. doi: 10.1007/s10620-009-0819-z. Epub 2009 May 23.
23. Pathogenic aspects of pulmonary complications in acute pancreatitis patients. Chooklin S Hepatobiliary Pancreat Dis Int. 2009 Apr;8(2):186-92.
24. Induction of interferon-gamma inducing factor in the adrenal cortex. Conti B, etal., J Biol Chem 1997 Jan 24;272(4):2035-7.
25. Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat. Daigo E, etal., Neurosci Lett. 2012 Oct 31;529(1):39-44. doi: 10.1016/j.neulet.2012.09.007. Epub 2012 Sep 18.
26. A molecular platform in neurons regulates inflammation after spinal cord injury. de Rivero Vaccari JP, etal., J Neurosci. 2008 Mar 26;28(13):3404-14.
27. The effect of chronic candesartan therapy on the metabolic profile and renal tissue cytokine levels in the obese Zucker rat. Ecelbarger CM, etal., Mediators Inflamm. 2010;2010:841343. Epub 2010 May 17.
28. Betaine supplementation protects against high-fructose-induced renal injury in rats. Fan CY, etal., J Nutr Biochem. 2014 Mar;25(3):353-62. doi: 10.1016/j.jnutbio.2013.11.010. Epub 2013 Dec 4.
29. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
30. Interleukin-18 protects mice against acute herpes simplex virus type 1 infection. Fujioka N, etal., J Virol. 1999 Mar;73(3):2401-9.
31. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
32. Interleukin-18 is a key mediator in dermatomyositis: potential contribution to development of interstitial lung disease. Gono T, etal., Rheumatology (Oxford). 2010 Oct;49(10):1878-81. Epub 2010 Jul 3.
33. Prognostic value of serum IL-18 and nitric oxide activity in breast cancer patients at operable stage. Gunel N, etal., Am J Clin Oncol. 2003 Aug;26(4):416-21.
34. Clinical importance of serum interleukin-18 and nitric oxide activities in breast carcinoma patients. Gunel N, etal., Cancer. 2002 Aug 1;95(3):663-7.
35. Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response. Haas SL, etal., J Clin Immunol. 2009 Sep;29(5):620-8. doi: 10.1007/s10875-009-9302-z. Epub 2009 May 20.
36. Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Halpern MD, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G695-702. Epub 2003 Jan 15.
37. Decreased development of necrotizing enterocolitis in IL-18-deficient mice. Halpern MD, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G20-6. Epub 2007 Oct 18.
38. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Halpern MD, etal., Pediatr Res 2002 Jun;51(6):733-9.
39. IL-18 mRNA expression and IFN-gamma induction in bronchoalveolar lavage from Behcet's disease. Hamzaoui A, etal., Clin Exp Rheumatol. 2003 Jul-Aug;21(4 Suppl 30):S8-14.
40. LncRNA H19 suppresses pyroptosis of cardiomyocytes to attenuate myocardial infarction in a PBX3/CYP1B1-dependent manner. Han Y, etal., Mol Cell Biochem. 2021 Mar;476(3):1387-1400. doi: 10.1007/s11010-020-03998-y. Epub 2021 Jan 3.
41. A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Harada M, etal., Am J Respir Crit Care Med. 2009 Dec 1;180(11):1048-55. Epub 2009 Sep 10.
42. Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. Harker JA, etal., J Virol. 2010 Apr;84(8):4073-82. Epub 2010 Feb 3.
43. Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever. Haznedaroglu S, etal., Clin Exp Rheumatol. 2005 Jul-Aug;23(4 Suppl 38):S77-80.
44. Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats. He J, etal., J Neurovirol. 2018 Feb;24(1):88-97. doi: 10.1007/s13365-017-0597-x. Epub 2017 Dec 19.
45. Interleukin-18 involvement in hypoxic-ischemic brain injury. Hedtjarn M, etal., J Neurosci 2002 Jul 15;22(14):5910-9.
46. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Hoshino T, etal., Am J Respir Cell Mol Biol. 2009 Dec;41(6):661-70. Epub 2009 Mar 5.
47. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Hoshino T, etal., Am J Respir Crit Care Med. 2007 Jul 1;176(1):49-62. Epub 2007 Mar 30.
48. Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan. Hsueh KC, etal., J Rheumatol. 2008 Jul;35(7):1408-13. Epub 2008 May 15.
49. IL18 polymorphism is associated with Behcet's disease but not lupus in patients from Turkey. Htoon J, etal., J Rheumatol. 2011 May;38(5):962-3. doi: 10.3899/jrheum.101202.
50. Tetramethylpyrazine accelerates the function recovery of traumatic spinal cord in rat model by attenuating inflammation. Hu JZ, etal., J Neurol Sci. 2013 Jan 15;324(1-2):94-9. doi: 10.1016/j.jns.2012.10.009. Epub 2012 Nov 7.
51. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
52. IL-18 contributes to host resistance against infection with Pseudomonas aeruginosa through induction of IFN-gamma production. Huang X, etal., J Immunol. 2002 Jun 1;168(11):5756-63.
53. Interleukin-18 gene polymorphisms in Egyptian patients with allergic diseases. Ibrahim GH, etal., Am J Rhinol Allergy. 2012 Sep-Oct;26(5):385-9. doi: 10.2500/ajra.2012.26.3806. Epub 2012 Jul 27.
54. Rat interleukin-18 binding protein: cloning, expression, and characterization. Im SH, etal., J Interferon Cytokine Res 2002 Mar;22(3):321-8.
55. The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study. Imboden M, etal., Clin Exp Allergy. 2006 Feb;36(2):211-8.
56. Predictive potential of IL-18 -607 and osteopontin -442 polymorphism in interferon-based therapy of HCV infection in the Pakistani population. Imran M, etal., Viral Immunol. 2014 Oct;27(8):404-11. doi: 10.1089/vim.2014.0044. Epub 2014 Sep 8.
57. Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy. Ino Y, etal., Clin Cancer Res. 2006 Jan 15;12(2):643-52.
58. Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat. Jander S and Stoll G, J Neuroimmunol. 1998 Nov 2;91(1-2):93-9.
59. Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response. Jander S, etal., J Cereb Blood Flow Metab. 2002 Jan;22(1):62-70.
60. Interleukin-18 gene polymorphisms in Korean patients with Behcet's disease. Jang WC, etal., Clin Exp Rheumatol. 2005 Jul-Aug;23(4 Suppl 38):S59-63.
61. Role of IL-18 in acute lung inflammation. Jordan JA, etal., J Immunol 2001 Dec 15;167(12):7060-8.
62. Interleukin-18 attenuates disruption of brain-blood barrier induced by status epilepticus within the rat piriform cortex in interferon-gamma independent pathway. Jung HK, etal., Brain Res. 2012 Apr 4;1447:126-34. Epub 2012 Jan 31.
63. Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats. Kalariya NM, etal., Invest Ophthalmol Vis Sci. 2012 Jun 8;53(7):3431-40. doi: 10.1167/iovs.12-9432.
64. Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin. Kawase Y, etal., J Invest Dermatol. 2003 Sep;121(3):502-9.
65. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Kempster SL, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Nov 18.
66. Association of interleukin-18 gene promoter polymorphisms with breast cancer. Khalili-Azad T, etal., Neoplasma. 2009;56(1):22-5.
67. The clinical significance of interleukin 18 assessment in sarcoidosis patients. Kieszko R, etal., Respir Med. 2007 Apr;101(4):722-8. Epub 2006 Oct 2.
68. Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans. Kim E, etal., Clin Exp Allergy. 2007 Jun;37(6):865-71.
69. A functional promoter polymorphism of the human IL18 gene is associated with aspirin-induced urticaria. Kim SH, etal., Br J Dermatol. 2011 Nov;165(5):976-84. doi: 10.1111/j.1365-2133.2011.10467.x. Epub 2011 Sep 15.
70. Association between interleukin 18 polymorphisms and alopecia areata in koreans. Kim SK, etal., J Interferon Cytokine Res. 2014 May;34(5):349-53. doi: 10.1089/jir.2013.0055. Epub 2014 Jan 21.
71. Effects of corticosteroids on expression of interleukin-18 in the airway mucosa of a mouse model of allergic rhinitis. Kim SW, etal., Ann Otol Rhinol Laryngol. 2007 Jan;116(1):76-80.
72. Role of interleukin-18 in intrahepatic inflammatory cell recruitment in acute liver injury. Kimura K, etal., J Leukoc Biol. 2011 Mar;89(3):433-42. doi: 10.1189/jlb.0710412. Epub 2010 Nov 24.
73. Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus. Kinoshita M, etal., Infect Immun. 2011 Jul;79(7):2670-80. doi: 10.1128/IAI.01298-10. Epub 2011 May 2.
74. Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. Kitasato Y, etal., Am J Respir Cell Mol Biol. 2004 Dec;31(6):619-25. Epub 2004 Aug 12.
75. Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment. Kolinska J, etal., J Interferon Cytokine Res. 2008 May;28(5):287-96.
76. Role of IL-18 in second-hand smoke-induced emphysema. Kratzer A, etal., Am J Respir Cell Mol Biol. 2013 Jun;48(6):725-32. doi: 10.1165/rcmb.2012-0173OC.
77. Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis. Kruse S, etal., J Allergy Clin Immunol. 2003 Jan;111(1):117-22.
78. Interleukin-18 promotes sleep in rabbits and rats. Kubota T, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Sep;281(3):R828-38.
79. Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. Kuroda-Morimoto M, etal., Int Immunol. 2010 Jul;22(7):561-70. Epub 2010 May 23.
80. Association between Interleukin-18 Polymorphisms and Hepatocellular Carcinoma Occurrence and Clinical Progression. Lau HK, etal., Int J Med Sci. 2016 Jul 5;13(7):556-61. doi: 10.7150/ijms.15853. eCollection 2016.
81. Association of interleukin-18 gene polymorphism with asthma in Chinese patients. Lee CC, etal., J Clin Lab Anal. 2008;22(1):39-44.
82. Interleukin-18/-607 gene polymorphism in allergic rhinitis. Lee HM, etal., Int J Pediatr Otorhinolaryngol. 2006 Jun;70(6):1085-8. Epub 2006 Jan 6.
83. Interleukin-18 promoter polymorphisms in patients with Behcet's disease. Lee YJ, etal., Hum Immunol. 2006 Oct;67(10):812-8. Epub 2006 Aug 23.
84. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. Leu S, etal., J Transl Med. 2010 Jun 28;8:63. doi: 10.1186/1479-5876-8-63.
85. Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation. Li C, etal., Arch Ophthalmol. 2007 Jun;125(6):795-803.
86. Association among plasma interleukin-18 levels, carotid intima- media thickness and severity of obstructive sleep apnea. Li C, etal., Chin Med J (Engl). 2009 Jan 5;122(1):24-9.
87. The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome. Li WW, etal., Pain. 2009 Dec 15;147(1-3):277-86. Epub 2009 Oct 22.
88. Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Li X, etal., Biochim Biophys Acta. 2012 Feb;1822(2):196-203. doi: 10.1016/j.bbadis.2011.09.019. Epub 2011 Oct 7.
89. Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD. Li Y, etal., Hepatogastroenterology. 2010 Jan-Feb;57(97):103-6.
90. Induction of an effective anti-tumor immune response and tumor regression by combined administration of IL-18 and Apoptin. Lian H, etal., Cancer Immunol Immunother. 2007 Feb;56(2):181-92. Epub 2006 Jun 10.
91. Association of IL18 genetic polymorphisms with increased risk of Biliary atresia susceptibility in Southern Chinese children. Liang J, etal., Gene. 2018 Nov 30;677:228-231. doi: 10.1016/j.gene.2018.07.071. Epub 2018 Jul 27.
92. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. Lichtnekert J, etal., PLoS One. 2011;6(10):e26778. Epub 2011 Oct 27.
93. Immunological markers of lung disease due to non-tuberculous mycobacteria. Lim A, etal., Dis Markers. 2010;29(2):103-9.
94. [Correlations between plasma levels of IL-18, IL-4, IFN-gamma, IgE and ECP in the patients with seasonal allergic rhinitis and their clinical implications] Lin X, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(5):195-7.
95. Adipose tissue expression of IL-18 and HIV-associated lipodystrophy. Lindegaard B, etal., AIDS. 2004 Sep 24;18(14):1956-8.
96. Serum concentrations of interleukin-18 in early and advanced cancer patients: enhanced secretion in metastatic disease. Lissoni P, etal., J Biol Regul Homeost Agents. 2000 Oct-Dec;14(4):275-7.
97. Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through Inhibition of Interleukin-18 Signaling. Liu X, etal., Transplantation. 2015 Oct;99(10):2109-17. doi: 10.1097/TP.0000000000000737.
98. Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease. Ludwiczek O, etal., J Clin Immunol. 2002 Nov;22(6):331-7.
99. Interleukin 1-beta, interleukin-1 receptor antagonist, and interleukin 18 in children with acute spontaneous urticaria. Machura E, etal., Biomed Res Int. 2013;2013:605262. doi: 10.1155/2013/605262. Epub 2013 Dec 29.
100. Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Maffia P, etal., Circulation. 2006 Aug 1;114(5):430-7. Epub 2006 Jul 24.
101. Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes. Markowitz GJ, etal., Cancer Res. 2016 Apr 15;76(8):2394-405. doi: 10.1158/0008-5472.CAN-15-1548. Epub 2016 Feb 18.
102. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. Melnikov VY, etal., J Clin Invest. 2001 May;107(9):1145-52.
103. Induction of the proinflammatory cytokine interleukin-18 by axonal injury. Menge T, etal., J Neurosci Res. 2001 Aug 15;65(4):332-9.
104. Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in mice. Menke J, etal., Kidney Int. 2011 Feb;79(4):452-63. Epub 2010 Oct 27.
105. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
106. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Micallef MJ, etal., Eur J Immunol. 1996 Jul;26(7):1647-51.
107. Interleukin-18 induces insulin resistance in the hyperthyroid state. Miyauchi S, etal., Endocr J. 2013;60(4):449-55. Epub 2012 Dec 19.
108. Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. Miyoshi K, etal., J Neurosci. 2008 Nov 26;28(48):12775-87. doi: 10.1523/JNEUROSCI.3512-08.2008.
109. Expression of interleukin-18 in a rat model of deep vein thrombosis. Mo J, etal., J Cardiovasc Surg (Torino). 2012 Oct;53(5):625-30. Epub 2012 Feb 8.
110. A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. Morel JC, etal., J Biol Chem. 2001 Oct 5;276(40):37069-75. Epub 2001 Jul 27.
111. Lack of association of interleukin-18 gene polymorphisms with susceptibility of Japanese populations to Graves' disease or Graves' ophthalmopathy. Mukai T, etal., Thyroid. 2006 Mar;16(3):243-8.
112. Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate. Mullen AB, etal., Immunology. 2006 Nov;119(3):348-54. Epub 2006 Jul 26.
113. Interleukin 18 and transforming growth factor beta1 in the serum of patients with Graves' ophthalmopathy treated with corticosteroids. Mysliwiec J, etal., Int Immunopharmacol. 2003 Apr;3(4):549-52.
114. Gene transfer of secreted-type modified interleukin-18 gene to B16F10 melanoma cells suppresses in vivo tumor growth through inhibition of tumor vessel formation. Nagai H, etal., J Invest Dermatol. 2002 Sep;119(3):541-8.
115. Involvement of interleukin 18 in lens opacification of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes. Nagai N, etal., Curr Eye Res. 2011 Jun;36(6):497-506. doi: 10.3109/02713683.2010.549602.
116. Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats. Nagai N, etal., J Biochem. 2007 Nov;142(5):597-603.
117. Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes. Naka T, etal., Prep Biochem Biotechnol. 2008;38(2):201-12.
118. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
119. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Netea MG, etal., Nat Med. 2006 Jun;12(6):650-6. doi: 10.1038/nm1415. Epub 2006 May 28.
120. Serum levels of interleukin-18 are elevated in the subacute phase of kawasaki syndrome. Nomura Y, etal., Int Arch Allergy Immunol. 2004 Oct;135(2):161-5. Epub 2004 Sep 2.
121. Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. Novak N, etal., J Allergy Clin Immunol. 2005 Apr;115(4):828-33.
122. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection. Ohkusu K, etal., Infect Immun. 2000 May;68(5):2449-56.
123. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
124. Suppressive effects of interleukin-18 on liver function in rat liver allografts. Ono S, etal., J Surg Res. 2012 Jul;176(1):293-300. doi: 10.1016/j.jss.2011.07.053. Epub 2011 Aug 27.
125. Global and gene-specific translational regulation in rat lung development. Otulakowski G, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):555-67. Epub 2008 Oct 23.
126. Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis. Palomino-Morales RJ, etal., Arthritis Res Ther. 2010;12(2):R51. doi: 10.1186/ar2962. Epub 2010 Mar 23.
127. Evidence of IL-18 as a novel angiogenic mediator. Park CC, etal., J Immunol. 2001 Aug 1;167(3):1644-53.
128. Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. Paterson GK, etal., J Med Microbiol. 2005 Apr;54(Pt 4):323-6.
129. Interleukin-18 promoter polymorphism in patients with atopic asthma. Pawlik A, etal., Tissue Antigens. 2007 Oct;70(4):314-8.
130. Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Pazos P, etal., Sci Rep. 2015 Dec 10;5:17977. doi: 10.1038/srep17977.
131. Plasma interleukin-18 and dendritic cells in males with psoriasis vulgaris. Pietrzak A, etal., Mediators Inflamm. 2007;2007:61254.
132. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
133. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
134. IL-18 binding protein protects against contact hypersensitivity. Plitz T, etal., J Immunol. 2003 Aug 1;171(3):1164-71.
135. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Puthothu B, etal., Pediatr Infect Dis J. 2007 Dec;26(12):1094-8.
136. Interleukin-18 regulates pathological intraocular neovascularization. Qiao H, etal., J Leukoc Biol. 2007 Apr;81(4):1012-21. Epub 2007 Jan 18.
137. Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions. Raggatt LJ, etal., J Biol Chem. 2008 Mar 14;283(11):6790-8. Epub 2007 Dec 28.
138. Interleukin-18 expression and the response to treatment in patients with psoriasis. Rasmy H, etal., Arch Med Sci. 2011 Aug;7(4):713-9. doi: 10.5114/aoms.2011.24144. Epub 2011 Sep 2.
139. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. Reeves EP, etal., J Immunol. 2010 Feb 1;184(3):1642-52. Epub 2009 Dec 21.
140. Different inflammatory responses are associated with Ureaplasma parvum-induced UTI and urolith formation. Reyes L, etal., BMC Infect Dis. 2009 Jan 26;9:9.
141. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
142. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
143. Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Rovina N, etal., Respir Med. 2009 Jul;103(7):1056-62. Epub 2009 Feb 8.
144. The protective effects of interleukin-18 and interferon-gamma on neuronal damages in the rat hippocampus following status epilepticus. Ryu HJ, etal., Neuroscience. 2010 Oct 27;170(3):711-21. Epub 2010 Jul 29.
145. ANALYSIS OF POLYMORPHISMS IN THE INTERLEUKIN 18 GENE PROMOTOR (-137 G/C AND -607 C/A) IN PATIENTS INFECTED WITH HEPATITIS C VIRUS FROM THE BRAZILIAN AMAZON. Santos KN, etal., Arq Gastroenterol. 2015 Jul-Sep;52(3):222-7. doi: 10.1590/S0004-28032015000300013.
146. IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity. Sasaki Y, etal., J Exp Med. 2005 Sep 5;202(5):607-16. Epub 2005 Aug 29.
147. Involvement of NK1.1+ {gamma}{delta}T Cells in the IL-18 Plus IL-2-Induced Interstitial Lung Disease. Segawa S, etal., Am J Respir Cell Mol Biol. 2011 Jan 21.
148. In vivo IL-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice: a novel anti-inflammatory role of IL-18. Sekine K, etal., Shock. 2009 Nov;32(5):554-62.
149. Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter. Shao PL, etal., Cardiology. 2010;115(2):130-44. Epub 2009 Dec 2.
150. Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-α in Patients with Intrahepatic Cholestasis of Pregnancy. Shao Y, etal., Cell Physiol Biochem. 2017;42(4):1294-1302. doi: 10.1159/000478958. Epub 2017 Jul 11.
151. Elevation of interleukin-18 in chronic hepatitis C: implications for hepatitis C virus pathogenesis. Sharma A, etal., Immunology. 2009 Sep;128(1 Suppl):e514-22. doi: 10.1111/j.1365-2567.2008.03021.x. Epub 2008 Nov 24.
152. Serum IL-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in IgA nephropathy. Shi B, etal., Mediators Inflamm. 2012;2012:728417. Epub 2012 Feb 6.
153. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Shimizu M, etal., Rheumatology (Oxford). 2010 Sep;49(9):1645-53. doi: 10.1093/rheumatology/keq133. Epub 2010 May 14.
154. Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases. Sifringer M, etal., Dev Neurosci. 2009;31(5):394-402. Epub 2009 Aug 11.
155. Activation of caspase-1 dependent interleukins in developmental brain trauma. Sifringer M, etal., Neurobiol Dis. 2007 Mar;25(3):614-22. Epub 2006 Dec 22.
156. Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy. Skopinski P, etal., J Diabetes Complications. 2005 Nov-Dec;19(6):335-8.
157. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
158. Interleukin-18 is associated with increased severity of atopic dermatitis in children. Sohn MH, etal., Allergy Asthma Proc. 2004 May-Jun;25(3):181-4.
159. Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. Spahr L, etal., Liver Int. 2004 Dec;24(6):582-7. doi: 10.1111/j.1478-3231.2004.0967.x.
160. Interleukin 18 expression in the primary breast cancer tumour tissue. Srabovic N, etal., Med Glas (Zenica). 2011 Feb;8(1):109-15.
161. The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis. Stolina M, etal., Biomarkers. 2008 Nov;13(7):692-712.
162. Interleukin-18 is expressed in rat testis and may promote germ cell growth. Strand ML, etal., Mol Cell Endocrinol. 2005 Aug 30;240(1-2):64-73.
163. Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS. Sugama S, etal., Brain Res 2002 Dec 20;958(1):1-9.
164. Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment. Sugama S, etal., J Immunol. 2000 Dec 1;165(11):6287-92.
165. Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. Sun Q, etal., J Biol Chem. 2013 May 31;288(22):15947-58. doi: 10.1074/jbc.M112.426791. Epub 2013 Apr 15.
166. Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice. Takeuchi D, etal., Hepatology. 2004 Mar;39(3):699-710. doi: 10.1002/hep.20117.
167. Interleukin-18 exacerbates pulmonary injury after hepatic ischemia/reperfusion in mice. Takeuchi D, etal., J Surg Res. 2010 Jan;158(1):87-93. Epub .
168. Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease. Takiyama Y, etal., Thyroid. 2002 Nov;12(11):935-43.
169. IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome. Tan HW, etal., Atherosclerosis. 2010 Feb;208(2):350-7. Epub 2009 Aug 7.
170. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. Tanaka H, etal., J Allergy Clin Immunol. 2001 Feb;107(2):331-6.
171. Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Tanaka T, etal., Int Arch Allergy Immunol. 2001 Jul;125(3):236-40.
172. Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies. Tucci M, etal., Clin Exp Immunol. 2006 Oct;146(1):21-31.
173. Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia. Urushihara N, etal., J Pediatr Surg. 2000 Mar;35(3):446-9.
174. Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18. Valente AJ, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H282-96. doi: 10.1152/ajpheart.00231.2012. Epub 2012 May 25.
175. Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus. Van Der Sluijs KF, etal., Immunology. 2005 Jan;114(1):112-20.
176. Systemic Elevation of Proinflammatory Interleukin 18 in HIV/HCV Coinfection versus HIV or HCV Monoinfection. Veenhuis RT, etal., Clin Infect Dis. 2017 Mar 1;64(5):589-596. doi: 10.1093/cid/ciw771. Epub 2016 Dec 7.
177. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. Venkatachalam K, etal., J Biol Chem. 2009 Mar 20;284(12):7853-65. Epub 2009 Jan 21.
178. Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. Walberer M, etal., Exp Transl Stroke Med. 2010 Dec 20;2(1):22.
179. Small interfering RNA targeting IKKbeta prevents renal ischemia-reperfusion injury in rats. Wan X, etal., Am J Physiol Renal Physiol. 2011 Apr;300(4):F857-63. Epub 2011 Feb 2.
180. Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease. Wang HN, etal., World J Gastroenterol. 2008 Dec 21;14(47):7240-6.
181. Protective effects of exogenous interleukin 18-binding protein in a rat model of acute renal ischemia-reperfusion injury. Wang J, etal., Shock. 2012 Mar;37(3):333-40. doi: 10.1097/SHK.0b013e318240bdc8.
182. [Influence of electroacupuncture stimulation on serum and hepatic interleukin-18 expression in nonalcoholic fatty liver rats]. Wang L, etal., Zhen Ci Yan Jiu. 2013 Jun;38(3):208-13.
183. Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats. Wang LW, etal., World J Gastroenterol. 2012 Oct 28;18(40):5709-18. doi: 10.3748/wjg.v18.i40.5709.
184. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Wang M, etal., Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17499-504. Epub 2009 Sep 25.
185. Breviscapine reduces acute lung injury induced by left heart ischemic reperfusion in rats by inhibiting the expression of ICAM-1 and IL-18. Wang Y, etal., Exp Ther Med. 2013 Nov;6(5):1322-1326. Epub 2013 Sep 4.
186. Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats. Wang Y, etal., J Reprod Immunol. 2011 Dec;92(1-2):45-53. doi: 10.1016/j.jri.2011.07.002. Epub 2011 Sep 13.
187. IL-18 enhances protective effect in mice immunized with a Schistosoma japonicum FABP DNA vaccine. Wei F, etal., Acta Trop. 2009 Sep;111(3):284-8. doi: 10.1016/j.actatropica.2009.03.010. Epub 2009 May 23.
188. Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Wei XQ, etal., Immunol Lett. 2004 Jun 15;94(1-2):35-7.
189. Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS. Wheeler RD, etal., Cytokine. 2003 Feb 21;21(4):161-6.
190. Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae. Wieland CW, etal., Infect Immun. 2007 Oct;75(10):5068-72. Epub 2007 Jul 30.
191. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. Wildbaum G, etal., J Immunol. 1998 Dec 1;161(11):6368-74.
192. Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats. Xing SS, etal., Mol Med. 2010 Nov-Dec;16(11-12):465-70. Epub 2010 Jul 12.
193. Expression of interleukin-18 in murine contact hypersensitivity. Xu B, etal., J Interferon Cytokine Res. 1998 Sep;18(9):653-9.
194. Adenoviral-mediated interleukin-18 expression in mesenchymal stem cells effectively suppresses the growth of glioma in rats. Xu G, etal., Cell Biol Int. 2009 Apr;33(4):466-74. doi: 10.1016/j.cellbi.2008.07.023. Epub 2008 Aug 6.
195. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. Xu J, etal., J Pediatr Gastroenterol Nutr. 2011 Feb;52(2):140-6.
196. Interleukin-18-deficient mice exhibit diminished chronic inflammation and airway remodelling in ovalbumin-induced asthma model. Yamagata S, etal., Clin Exp Immunol. 2008 Dec;154(3):295-304. Epub 2008 Sep 23.
197. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Yamanaka K, etal., Clin Cancer Res. 2006 Jan 15;12(2):376-82.
198. Therapeutic effect of pEgr-IL18-B7.2 gene radiotherapy in B16 melanoma-bearing mice. Yang J, etal., Hum Gene Ther. 2007 Apr;18(4):323-32.
199. Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy. Yang LP, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2319-27. Epub 2008 Nov 14.
200. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
201. Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion. Yang YJ, etal., World J Gastroenterol. 2005 Aug 7;11(29):4524-9.
202. The roles of interleukin-18 in collagen-induced arthritis in the BB rat. Ye XJ, etal., Clin Exp Immunol. 2004 Jun;136(3):440-7.
203. The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances. Ye XJ, etal., Clin Exp Immunol. 2007 Sep;149(3):553-60. Epub 2007 Jul 10.
204. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Zhang DQ, etal., Evid Based Complement Alternat Med. 2013;2013:731932. doi: 10.1155/2013/731932. Epub 2013 Jul 28.
205. Interleukin 18 accelerates the hepatic cell proliferation in rat liver regeneration after partial hepatectomy. Zhang J, etal., Gene. 2014 Mar 10;537(2):230-7. doi: 10.1016/j.gene.2013.12.062. Epub 2014 Jan 9.
206. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. Zhang J, etal., J Ethnopharmacol. 2013 Jul 9;148(2):563-9. doi: 10.1016/j.jep.2013.04.053. Epub 2013 May 16.
207. [Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus]. Zhang QX, etal., Zhonghua Gan Zang Bing Za Zhi. 2016 May 20;24(5):352-7. doi: 10.3760/cma.j.issn.1007-3418.2016.05.008.
208. Efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of rats with severe acute pancreatitis. Zhang R, etal., Inflammation. 2009 Apr;32(2):109-19.
209. Reduced MIR130A is involved in primary immune thrombocytopenia via targeting TGFB1 and IL18. Zhao H, etal., Br J Haematol. 2014 Sep;166(5):767-73. doi: 10.1111/bjh.12934. Epub 2014 May 7.
Additional References at PubMed
PMID:9702748   PMID:10048765   PMID:10227969   PMID:10227975   PMID:10653850   PMID:10843730   PMID:10903731   PMID:11131641   PMID:11429161   PMID:11714750   PMID:11894097   PMID:11894098  
PMID:11907086   PMID:12787406   PMID:12829194   PMID:14528293   PMID:15220916   PMID:15843532   PMID:15890643   PMID:16460811   PMID:16482511   PMID:16707557   PMID:16949315   PMID:17010950  
PMID:17220368   PMID:17352829   PMID:18504504   PMID:18662782   PMID:19088061   PMID:19666510   PMID:20027291   PMID:21147091   PMID:21273803   PMID:21321938   PMID:21323571   PMID:21442623  
PMID:21882482   PMID:22642744   PMID:23132931   PMID:23376485   PMID:23725508   PMID:23747799   PMID:23823918   PMID:23844157   PMID:24414074   PMID:24615654   PMID:24816434   PMID:25022959  
PMID:25500532   PMID:25752290   PMID:25918710   PMID:26004155   PMID:26252165   PMID:26424019   PMID:26558633   PMID:26725437   PMID:28373090   PMID:29786104   PMID:31923399   PMID:33051554  
PMID:33137409   PMID:33236152   PMID:34369678   PMID:34890588   PMID:36042379   PMID:36591929   PMID:37566022  


Genomics

Comparative Map Data
Il18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,802,072 - 59,829,275 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,809,592 - 59,831,286 (+)EnsemblGRCr8
mRatBN7.2850,904,630 - 50,932,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,411,470 - 56,438,574 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,690,368 - 54,717,472 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,554,644 - 52,581,752 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,009,666 - 55,016,286 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)Ensemblrn6Rnor6.0
Rnor_5.0853,606,988 - 53,613,608 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,936,584 - 53,943,228 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,474,845 - 50,479,055 (+)NCBICelera
RGSC_v3.1853,955,637 - 53,962,282 (+)NCBI
Cytogenetic Map8q23NCBI
IL18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,143,260 - 112,164,094 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,143,251 - 112,164,106 (-)Ensemblhg38GRCh38
GRCh3711112,013,983 - 112,034,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,519,186 - 111,540,050 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411111,519,185 - 111,540,050NCBI
Celera11109,167,214 - 109,188,073 (-)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,938,095 - 107,959,011 (-)NCBIHuRef
CHM1_111111,897,441 - 111,918,303 (-)NCBICHM1_1
T2T-CHM13v2.011112,153,592 - 112,174,423 (-)NCBIT2T-CHM13v2.0
Il18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,466,000 - 50,493,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,466,127 - 50,493,140 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38950,554,700 - 50,581,841 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,554,827 - 50,581,840 (+)Ensemblmm10GRCm38
MGSCv37950,373,473 - 50,389,942 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36950,317,598 - 50,334,067 (+)NCBIMGSCv36mm8
Celera947,860,314 - 47,877,082 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Il18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,806,553 - 13,825,634 (-)Ensembl
ChiLan1.0NW_00495541213,807,361 - 13,826,007 (-)NCBIChiLan1.0ChiLan1.0
IL18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,888,641 - 112,913,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,981,627 - 114,007,032 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011107,024,376 - 107,045,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,867,586 - 110,888,371 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,867,586 - 110,888,371 (-)EnsemblpanPan2panpan1.1
IL18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1520,972,742 - 20,995,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl520,972,871 - 20,995,348 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha520,907,590 - 20,917,853 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0520,994,967 - 21,017,974 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl520,995,094 - 21,019,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,069,981 - 21,080,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0520,970,245 - 20,980,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,018,633 - 21,028,888 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,380,523 - 94,398,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,306,875 - 2,325,189 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,306,963 - 2,325,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,834,973 - 39,861,219 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1939,839,959 - 39,861,258 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,692,120 - 44,713,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,485,868 - 103,511,632 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1103,482,083 - 103,510,150 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604322,475,303 - 22,498,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,294,183 - 7,304,687 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247847,294,286 - 7,312,959 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Il18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1845,029,011 - 45,055,185 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il18
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:53
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000013093
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF226163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ222813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY077842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY258448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ230329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013093   ⟹   ENSRNOP00000013093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,822,659 - 59,829,275 (+)Ensembl
mRatBN7.2 Ensembl850,926,271 - 50,932,887 (+)Ensembl
Rnor_6.0 Ensembl854,993,859 - 55,016,299 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108779   ⟹   ENSRNOP00000082676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,809,592 - 59,831,286 (+)Ensembl
mRatBN7.2 Ensembl850,906,960 - 50,932,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119850   ⟹   ENSRNOP00000081241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,809,592 - 59,828,942 (+)Ensembl
mRatBN7.2 Ensembl850,906,960 - 50,932,554 (+)Ensembl
RefSeq Acc Id: NM_019165   ⟹   NP_062038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,802,072 - 59,829,275 (+)NCBI
mRatBN7.2850,905,681 - 50,932,887 (+)NCBI
Rnor_6.0855,009,666 - 55,016,286 (+)NCBI
Rnor_5.0853,606,988 - 53,613,608 (+)NCBI
RGSC_v3.4853,936,584 - 53,943,228 (+)RGD
Celera850,474,845 - 50,479,055 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080940   ⟹   XP_038936868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,807,859 - 59,829,275 (+)NCBI
mRatBN7.2850,916,216 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080944   ⟹   XP_038936872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,443 - 59,829,275 (+)NCBI
mRatBN7.2850,904,794 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080945   ⟹   XP_038936873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,822,599 - 59,829,275 (+)NCBI
mRatBN7.2850,904,788 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_039080947   ⟹   XP_038936875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,823,916 - 59,829,275 (+)NCBI
mRatBN7.2850,927,528 - 50,932,887 (+)NCBI
RefSeq Acc Id: XM_063265003   ⟹   XP_063121073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,820,965 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265004   ⟹   XP_063121074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,818,805 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265005   ⟹   XP_063121075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,688 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265006   ⟹   XP_063121076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,820,965 - 59,829,275 (+)NCBI
RefSeq Acc Id: XM_063265008   ⟹   XP_063121078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,813,688 - 59,829,275 (+)NCBI
RefSeq Acc Id: NP_062038   ⟸   NM_019165
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013093   ⟸   ENSRNOT00000013093
RefSeq Acc Id: XP_038936873   ⟸   XM_039080945
- Peptide Label: isoform X2
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038936872   ⟸   XM_039080944
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936868   ⟸   XM_039080940
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936875   ⟸   XM_039080947
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000081241   ⟸   ENSRNOT00000119850
Ensembl Acc Id: ENSRNOP00000082676   ⟸   ENSRNOT00000108779
RefSeq Acc Id: XP_063121075   ⟸   XM_063265005
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121078   ⟸   XM_063265008
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121074   ⟸   XM_063265004
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121073   ⟸   XM_063265003
- Peptide Label: isoform X1
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063121076   ⟸   XM_063265006
- Peptide Label: isoform X3
- UniProtKB: Q541E6 (UniProtKB/Swiss-Prot),   P97637 (UniProtKB/Swiss-Prot),   P97636 (UniProtKB/Swiss-Prot),   O88749 (UniProtKB/Swiss-Prot),   A0A8I5ZXP8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97636-F1-model_v2 AlphaFold P97636 1-194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695945
Promoter ID:EPDNEW_R6470
Type:initiation region
Name:Il18_1
Description:interleukin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,000,448 - 55,000,508EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2889 AgrOrtholog
BioCyc Gene G2FUF-30562 BioCyc
Ensembl Genes ENSRNOG00000009848 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013093 ENTREZGENE
  ENSRNOT00000108779 ENTREZGENE
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot
InterPro IL-18 UniProtKB/Swiss-Prot
  IL-1_fam UniProtKB/Swiss-Prot
  IL1/FGF UniProtKB/Swiss-Prot
KEGG Report rno:29197 UniProtKB/Swiss-Prot
NCBI Gene 29197 ENTREZGENE
PANTHER INTERLEUKIN-1 FAMILY MEMBER UniProtKB/Swiss-Prot
  INTERLEUKIN-18 UniProtKB/Swiss-Prot
Pfam IL1 UniProtKB/Swiss-Prot
PhenoGen Il18 PhenoGen
PIRSF Interleukin_18 UniProtKB/Swiss-Prot
PRINTS INTRLEUKIN18 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009848 RatGTEx
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSJ0_RAT UniProtKB/TrEMBL
  A0A8I5ZXP8 ENTREZGENE, UniProtKB/TrEMBL
  A6J4D9_RAT UniProtKB/TrEMBL
  IL18_RAT UniProtKB/Swiss-Prot
  O88749 ENTREZGENE
  P97636 ENTREZGENE
  P97637 ENTREZGENE
  Q541E6 ENTREZGENE
  Z4YNI9_RAT UniProtKB/TrEMBL
UniProt Secondary O88749 UniProtKB/Swiss-Prot
  P97637 UniProtKB/Swiss-Prot
  Q541E6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il18  interleukin 18      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease plays a role in the injurious processes in the brain after hypoxic-ischemic (HI) 628353
gene_expression expressed in neurons of the superior part of the medial habenula (MHbS) 727478
gene_expression expressed in brain 628353
gene_homology closely related to IL-1b and similar in terms of structure, processing, receptor complex, signal transduction pathway, and proinflammatory properties 628353
gene_other synthesized as inactive precursors that require cleavage by caspase-1 to become fully bioactive 628353
gene_process in nervous system acts to induce sleep and to influence long-term potentiation 727478
gene_regulation expression increased after ischemia/reperfusion in the kidney and heart 628353
gene_regulation expression is greatly increased in microglia after hypoxic-ischemic (HI) 628353