RGD Reference Report - Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae. - Rat Genome Database

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Interleukin 18 participates in the early inflammatory response and bacterial clearance during pneumonia caused by nontypeable Haemophilus influenzae.

Authors: Wieland, CW  Florquin, S  Van der Poll, T 
Citation: Wieland CW, etal., Infect Immun. 2007 Oct;75(10):5068-72. Epub 2007 Jul 30.
RGD ID: 4889913
Pubmed: PMID:17664259   (View Abstract at PubMed)
PMCID: PMC2044539   (View Article at PubMed Central)
DOI: DOI:10.1128/IAI.00287-07   (Journal Full-text)

Nontypeable Haemophilus influenzae (NTHi) is a common gram-negative respiratory pathogen. To determine the role of the proinflammatory cytokine interleukin 18 (IL-18) during NTHi pneumonia, normal wild-type (WT) and IL-18 knockout (KO) mice were intranasally infected with NTHi. IL-18 KO mice displayed a delayed clearance of NTHi from the respiratory tract, resulting in >20-fold higher bacterial loads in their lungs at 24 h after infection, preceded by a strongly attenuated pulmonary innate immune response as determined by cytokine and chemokine induction and histopathology. These data identify IL-18 as part of an adequate innate immune response during NTHi pneumonia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bacterial pneumonia  ISOIl18 (Mus musculus)4889913; 4889913 RGD 
bacterial pneumonia  IMP 4889913 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information