RGD Reference Report - Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis. - Rat Genome Database

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Circulating concentrations of interleukin-18, interleukin-18 binding protein, and gamma interferon in patients with alcoholic hepatitis.

Authors: Spahr, Laurent  Garcia, Irène  Bresson-Hadni, Solange  Rubbia-Brandt, Laura  Guler, Reto  Olleros, Maria  Chvatchko, Yolande  Hadengue, Antoine 
Citation: Spahr L, etal., Liver Int. 2004 Dec;24(6):582-7. doi: 10.1111/j.1478-3231.2004.0967.x.
RGD ID: 14696666
Pubmed: PMID:15566508   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1478-3231.2004.0967.x   (Journal Full-text)


BACKGROUND: Alcoholic hepatitis (AH) is associated with dysregulated inflammatory and immune responses. interleukin-18 (IL-18), described as gamma interferon (gammaIFN)-inducible factor, and its natural antagonist, IL-18 binding protein (IL-18 BP), has not been fully studied in patients with AH. Thus, our aim was: (i) to determine plasma values of IL-18, IL-18 BP, gammaIFN, and tumor necrosis factor alpha (TNF)-alpha in patients hospitalized for biopsy-proven AH; (ii) to correlate these cytokines with the severity of AH, as assessed by Maddrey's discriminant function (DF), the degree of liver failure using the Child-Pugh score and blood neutrophils; (iii) to compare cytokines values in survivors and non-survivors.
METHODS: Cytokines were measured using specific immunoassays within 7 days of admission. The diagnosis of AH was based on histology in all cases. We studied 43 cirrhotic patients with a Maddrey's DF>/=32 (severe AH), 29 patients with a score <32 (non-severe AH), 12 patients with abstinent alcoholic cirrhosis, and 10 healthy subjects.
RESULTS: IL-18 and TNFalpha were increased in severe AH as compared with healthy subjects. Plasma IL-18 BP was elevated in patients with severe and non-severe AH as compared with healthy subjects. gammaIFN did not differ between groups. In patients with severe and non-severe AH, IL-18, IL-18 BP, TNFalpha, but not gammaIFN, were positively correlated to DF and Child-Pugh score. Neither IL-18 nor IL-18 BP correlated to TNFalpha. Patients who died (n=10) during the hospitalization had higher IL-18 BP and TNFalpha at admission as compared with survivors (322 [172-504] vs 222 [109-441] ng/ml; 7.5 [2.2-17.3] vs 3 [0.6-20] pg/ml, P<0.01, respectively).
CONCLUSION: In cirrhotic patients with AH, IL-18, IL-18 BP, and TNFalpha correlate to the hepatitis severity and to the degree of liver failure. High IL-18 BP and TNFalpha at hospital admission in non-survivors suggest it may be of prognostic value.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
alcoholic hepatitis severityIEP 14696666associated alcoholic liver cirrhosis and protein:increased expression:plasma:RGD 
alcoholic hepatitis severityISOIL18 (Homo sapiens)14696666; 14696666associated alcoholic liver cirrhosis and protein:increased expression:plasma:RGD 
alcoholic liver cirrhosis  IEP 14696666protein:increased expression:plasma:RGD 
alcoholic liver cirrhosis  ISOIL18BP (Homo sapiens)14696666; 14696666protein:increased expression:plasma:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)
Il18bp  (interleukin 18 binding protein)

Genes (Mus musculus)
Il18  (interleukin 18)
Il18bp  (interleukin 18 binding protein)

Genes (Homo sapiens)
IL18  (interleukin 18)
IL18BP  (interleukin 18 binding protein)


Additional Information