RGD Reference Report - High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection. - Rat Genome Database

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High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection.

Authors: Chattergoon, Michael A  Levine, Jordana S  Latanich, Rachel  Osburn, William O  Thomas, David L  Cox, Andrea L 
Citation: Chattergoon MA, etal., J Infect Dis. 2011 Dec 1;204(11):1730-40. doi: 10.1093/infdis/jir642. Epub 2011 Oct 7.
RGD ID: 14696657
Pubmed: PMID:21984735   (View Abstract at PubMed)
PMCID: PMC3203233   (View Article at PubMed Central)
DOI: DOI:10.1093/infdis/jir642   (Journal Full-text)


BACKGROUND: Proinflammatory cytokines play a critical role in antiviral immune responses. Large-scale genome studies have found correlations between single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 18 promoter and spontaneous control of hepatitis C virus (HCV), suggesting a role in clearance.
METHODS: Plasma IL-18, IL-1β, IL-6, IL-8, IL-12, interferon-γ, tumor necrosis factor-α, alanine aminotransferase (ALT), and HCV RNA levels were assessed longitudinally in subjects with known dates of HCV acquisition and analyzed according to IL-18 SNPs and outcome, either spontaneous clearance (SC) (n = 13) or persistent infection (PI) (n = 25).
RESULTS: No significant change in plasma proinflammatory cytokine expression was observed with the exception of IL-18, which increased in every subject with initial detection of HCV RNA. In every SC subject, IL-18 returned to the preinfection baseline concomitant with HCV control. In PI subjects, IL-18 declined following the acute phase of infection but remained above the preinfection baseline throughout chronic infection and did not correlate with HCV RNA or ALT levels.
CONCLUSIONS: Plasma IL-18 was an early and the most reliably detected host response to HCV infection measured in blood. Reduced IL-18 production with transition to chronic infection without correlation with HCV RNA or ALT levels suggests modulation of the innate response with persistent infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18Humanhepatitis C disease_progressionIEP  RGD 
Il18Rathepatitis C disease_progressionISOIL18 (Homo sapiens) RGD 
Il18Mousehepatitis C disease_progressionISOIL18 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information