RGD Reference Report - Serum IL-18 levels in tuberculosis: comparison with pneumonia, lung cancer and healthy controls. - Rat Genome Database

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Serum IL-18 levels in tuberculosis: comparison with pneumonia, lung cancer and healthy controls.

Authors: Akgun, M  Saglam, L  Kaynar, H  Yildirim, AK  Mirici, A  Gorguner, M  Meral, M  Ozden, K 
Citation: Akgun M, etal., Respirology. 2005 Jun;10(3):295-9.
RGD ID: 4889836
Pubmed: PMID:15955140   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1843.2005.00710.x   (Journal Full-text)

OBJECTIVE: The aim of the present study was to document the serum IL-18 levels in patients with pulmonary tuberculosis (P-TB), extrapulmonary tuberculosis (EP-TB), pneumonia, lung cancer and in healthy controls, and to investigate whether it may assist in the differential diagnosis of P-TB. METHODOLOGY: A total of 116 patients were included in the study. The study population consisted of patients with P-TB, EP-TB, pneumonia and lung cancer and controls. P-TB patients were graded according to sputum positivity and extent of disease. Serum levels of IL-18 (ELISA) were compared between groups and with other clinical measures of disease. RESULTS: Compared with the controls, all groups of patients had increased serum levels of IL-18. The highest mean concentration of IL-18 was observed in P-TB. Serum levels of IL-18 in the patients with P-TB correlated well with the extent of disease. CONCLUSIONS: Although increased serum levels of IL-18 were not specific for TB, the increased levels may favour active TB in radiologically advanced disease where CXR findings are difficult to interpret, and sputum smears or cultures are not helpful.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung non-small cell carcinoma  IEP 4889836protein:increased expression:serumRGD 
lung non-small cell carcinoma  ISOIL18 (Homo sapiens)4889836; 4889836protein:increased expression:serumRGD 
pneumonia  IEP 4889836protein:increased expression:serumRGD 
pneumonia  ISOIL18 (Homo sapiens)4889836; 4889836protein:increased expression:serumRGD 
pulmonary tuberculosis  IEP 4889836protein:increased expression:serumRGD 
pulmonary tuberculosis  ISOIL18 (Homo sapiens)4889836; 4889836protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information