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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2889 Species: Rattus norvegicus RGD Object: Gene Symbol: Il18 Name: interleukin 18

Acc ID: CHEBI:51052 Term: lucanthone Definition: A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. CasRN: 479-50-5 Chemical ID: MESH:D008154

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:730894	6480464	CTD	Lucanthone results in decreased expression of IL18 mRNA	PMID:21148553