RGD Reference Report - Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats. - Rat Genome Database

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Involvement of interleukin 18 in cataract development in hereditary cataract UPL rats.

Authors: Nagai, N  Ito, Y  Okamura, H 
Citation: Nagai N, etal., J Biochem. 2007 Nov;142(5):597-603.
RGD ID: 8655879
Pubmed: PMID:18006521   (View Abstract at PubMed)
DOI: DOI:10.1093/jb/mvm168   (Journal Full-text)

Our previous studies have demonstrated that lens epithelial damage by excessive nitric oxide causes an elevation in lens opacification in UPL rats, and it has been reported that interferon-gamma production in lens epithelial cells is involved in cataract development. In this study, we investigated the involvement of interleukin (IL)-18, which leads to interferon-gamma, in UPL rat lenses. The opacification of UPL rat lenses starts at 39 days of age. The gene expression levels causing IL-18 activation (IL-18, IL-18 receptor and caspase-1) are increased at 32 days of age, and the expression of mature IL-18 protein in the UPL rat lenses also increases with ageing. On the other hand, the interferon-gamma levels in UPL rat lenses are increased, and the increase in interferon-gamma levels in UPL rat lenses reaches a maximum at 39 days of age. Mature IL-18 expression and interferon-gamma production are achieved prior to the onset of lens opacification. In conclusion, the expression levels of IL-18 in the lenses of UPL rats are increased with aging. In addition, interferon-gamma levels in the lenses of UPL rats are also increased. It is possible that interferon-gamma generated by the activated IL-18 may induce cataract development in UPL rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cataract  ISOIl18 (Rattus norvegicus)8655879; 8655879 RGD 
cataract  IEP 8655879 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information